Detailed information    

insolico Bioinformatically predicted

Overview

Name   htrA   Type   Regulator
Locus tag   A6J72_RS05410 Genome accession   NZ_CP020433
Coordinates   1089373..1090563 (-) Length   396 a.a.
NCBI ID   WP_009569739.1    Uniprot ID   A0AAE8FYX2
Organism   Streptococcus intermedius strain FDAARGOS_233     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 1084373..1095563
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  A6J72_RS05385 (A6J72_05400) - 1084970..1085470 (+) 501 WP_082311947.1 DUF1307 domain-containing protein -
  A6J72_RS05390 (A6J72_05405) - 1085493..1085690 (-) 198 WP_003075608.1 DUF951 domain-containing protein -
  A6J72_RS05395 (A6J72_05410) dnaN 1085690..1086826 (-) 1137 WP_003075500.1 DNA polymerase III subunit beta -
  A6J72_RS05400 (A6J72_05415) dnaA 1086982..1088325 (-) 1344 WP_009569743.1 chromosomal replication initiator protein DnaA -
  A6J72_RS05405 (A6J72_05420) spo0J 1088551..1089318 (-) 768 WP_009569741.1 ParB/RepB/Spo0J family partition protein Regulator
  A6J72_RS05410 (A6J72_05425) htrA 1089373..1090563 (-) 1191 WP_009569739.1 S1C family serine protease Regulator
  A6J72_RS05415 (A6J72_05430) rlmH 1090767..1091246 (+) 480 WP_082311948.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  A6J72_RS05425 (A6J72_05440) - 1091523..1091669 (+) 147 WP_003075491.1 bacteriocin -
  A6J72_RS05430 (A6J72_05445) comD/comD1 1091686..1093011 (+) 1326 WP_216641942.1 GHKL domain-containing protein Regulator
  A6J72_RS05435 (A6J72_05450) comE 1093011..1093760 (+) 750 WP_003075488.1 competence system response regulator transcription factor ComE Regulator

Sequence

Protein


Download         Length: 396 a.a.        Molecular weight: 41833.00 Da        Isoelectric Point: 10.2415

>NTDB_id=223002 A6J72_RS05410 WP_009569739.1 1089373..1090563(-) (htrA) [Streptococcus intermedius strain FDAARGOS_233]
MKNSSNFTKKFLWLFMVLAIGFIGGLLGNVTSSKLNKNNTTTTKVNHVTTSYKNTNSTTQAVNKVKDAVVSVITYANNKS
QNSIFGNDDFNSNNNNSQRVASEGSGVIYKKDSKYAYLVTNTHVINGASKVDIRLADGNKVPGKIVGSDTYSDISVVRIS
ASKVKSVAEFGDSSKLTVGETAIAIGSPLGSNYANTVTQGIISSLNRNVSLKSEDGQTISTQAIQTDTAINPGNSGGPLV
NIQGQVIGITSSKIASNRGTSVEGLGFAIPSNDVTNIISQLESNGAVTRPALGIQMIDISNLSSSDLSRLKLPAKVTAGV
VVRSAQSGMPAAGKLQKYDVITKIDGKDISSANDLQSALYKHSIGDDIKITFYRNGKETTTTIKLTKSTKDLNSNN

Nucleotide


Download         Length: 1191 bp        

>NTDB_id=223002 A6J72_RS05410 WP_009569739.1 1089373..1090563(-) (htrA) [Streptococcus intermedius strain FDAARGOS_233]
ATGAAAAACTCTTCAAATTTCACAAAAAAATTCTTATGGCTTTTCATGGTCTTAGCTATAGGTTTTATTGGTGGTTTATT
AGGAAATGTAACTTCTTCAAAATTAAATAAAAACAACACAACTACTACTAAGGTTAATCATGTTACTACATCTTATAAAA
ATACCAATTCTACAACACAGGCTGTCAATAAAGTAAAGGATGCTGTTGTTTCTGTTATTACCTATGCTAATAATAAATCT
CAAAATAGCATTTTTGGAAATGATGACTTTAATAGTAACAATAATAACTCACAAAGAGTAGCAAGCGAAGGTTCAGGGGT
TATTTATAAAAAAGACAGTAAGTATGCCTATCTTGTAACTAATACTCATGTTATTAATGGTGCTAGTAAAGTGGATATTC
GTTTAGCGGATGGTAACAAAGTTCCAGGAAAAATCGTAGGCTCAGATACTTACTCAGATATTTCTGTCGTCCGTATTAGT
GCGAGCAAAGTCAAGTCAGTTGCTGAATTTGGTGATTCTAGTAAATTAACTGTTGGAGAAACTGCTATTGCTATTGGTAG
CCCACTTGGATCAAATTATGCAAATACTGTTACTCAAGGAATTATTTCTAGCTTAAATCGTAATGTGTCTTTAAAATCTG
AAGATGGTCAAACTATCTCTACTCAGGCTATTCAAACAGATACAGCGATTAATCCTGGGAATTCTGGTGGTCCACTTGTA
AATATCCAAGGGCAAGTTATTGGTATTACTTCAAGTAAAATTGCTAGTAATCGTGGAACATCTGTAGAGGGATTAGGTTT
TGCTATTCCATCTAATGATGTCACCAACATCATCAGCCAATTGGAATCAAACGGAGCAGTTACGCGACCAGCTTTAGGAA
TTCAAATGATTGATATTAGTAATCTATCTAGTTCTGATTTATCACGTTTGAAACTTCCAGCAAAAGTGACTGCAGGAGTT
GTTGTTCGTTCAGCTCAGTCTGGAATGCCTGCAGCAGGAAAACTTCAAAAATATGATGTTATTACAAAGATAGATGGAAA
AGACATTTCCTCAGCAAATGATTTACAATCTGCTTTATACAAACATTCAATTGGTGATGATATAAAAATTACATTTTATC
GTAATGGAAAAGAAACAACCACCACCATTAAACTTACAAAATCTACAAAAGATTTAAATTCAAATAATTGA

Domains

Predicted by InterproScan.

PDZ domain (PDZ_2)

(290-385)

Peptidase family M50 (Peptidase_M50)

(265-390)

Trypsin-like peptidase domain (Trypsin_2)

(104-249)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  htrA Streptococcus gordonii str. Challis substr. CH1

74.194

100

0.755
  htrA Streptococcus mitis NCTC 12261

71.285

100

0.715
  htrA Streptococcus pneumoniae D39

71.033

100

0.712
  htrA Streptococcus pneumoniae TIGR4

71.033

100

0.712
  htrA Streptococcus pneumoniae R6

71.033

100

0.712
  htrA Streptococcus pneumoniae Rx1

71.033

100

0.712
  htrA Streptococcus mutans UA159

57.289

98.737

0.566

Multiple sequence alignment