Detailed information NTG0197396

Bioinformatically predicted

Overview

• Name: comE/comE2
• Type: Regulator
• Locus tag: WH25_RS00905
• Genome accession: NZ_CP017295
• Coordinates: 169064..169831 (-)
• Length: 255 a.a.
• NCBI ID: WP_008808031.1
• Uniprot ID: P75031
• Organism: Streptococcus gordonii strain IE35
• Function: activate transcription of early competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 164064..174831

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
WH25_RS00885 (WH25_00885)	pth	166984..167553 (-)	570	WP_046164770.1	aminoacyl-tRNA hydrolase	-
WH25_RS00890 (WH25_00890)	ychF	167627..168742 (-)	1116	WP_008808030.1	redox-regulated ATPase YchF	-
WH25_RS00905 (WH25_00905)	comE/comE2	169064..169831 (-)	768	WP_008808031.1	competence system response regulator transcription factor ComE	Regulator
WH25_RS00910 (WH25_00910)	comD/comD2	169828..171186 (-)	1359	WP_046165176.1	competence system sensor histidine kinase ComD	Regulator
WH25_RS10570	comC/comC1	171202..171366 (-)	165	WP_080998577.1	bacteriocin	Regulator
WH25_RS00925 (WH25_00925)	rlmH	171652..172131 (-)	480	WP_008808034.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
WH25_RS00930 (WH25_00930)	htrA	172325..173518 (+)	1194	WP_046164771.1	S1C family serine protease	Regulator
WH25_RS00935 (WH25_00935)	spo0J	173584..174348 (+)	765	WP_046164772.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 255 a.a.
• Molecular weight: 30225.48 Da
• Isoelectric Point: 7.0651

>NTDB_id=197396 WH25_RS00905 WP_008808031.1 169064..169831(-) (comE/comE2) [Streptococcus gordonii strain IE35]
MKVLVLEDTIEHQVRIENVFEEISRELNLEIKAKVTGKIHEFKEYVESDEVNQLYFLDIDIKGEEQKGLEMAQFIRQHNP
YAIIVFVTSHSEFATLTFKYKVSALDFIDKDINDNSFKKRVKDCIVYTRNNLIENTDIVDFFEYSFRGNEIRIPFRDILY
IETTGSPYKLRVVGKNFFKEFYGTIAEIQEQDKELGYFFSPHKSYLSNISNISGYDKKTKDVLYYDGHRSPISRLRVRYL
KEILKAKSKKEENKK

Nucleotide

• Length: 768 bp

>NTDB_id=197396 WH25_RS00905 WP_008808031.1 169064..169831(-) (comE/comE2) [Streptococcus gordonii strain IE35]
ATGAAAGTATTAGTGCTAGAAGATACTATTGAACATCAAGTGAGAATTGAAAATGTCTTCGAAGAAATTTCTCGCGAACT
TAATCTTGAAATTAAAGCAAAAGTAACAGGAAAAATTCATGAATTTAAAGAATATGTTGAGTCAGACGAGGTAAATCAAC
TCTATTTCTTAGATATAGATATCAAAGGAGAAGAACAAAAAGGTCTAGAAATGGCGCAATTTATACGTCAACATAATCCC
TATGCTATCATTGTTTTTGTCACGAGTCATTCAGAATTTGCGACTTTAACTTTTAAGTATAAAGTATCAGCGTTAGATTT
TATAGATAAAGACATAAATGATAATTCTTTTAAGAAAAGAGTTAAAGATTGTATCGTTTATACACGAAATAATTTAATTG
AAAATACAGATATTGTTGACTTTTTTGAGTATAGTTTTAGAGGAAACGAAATTCGAATTCCTTTTAGAGATATTTTATAT
ATTGAGACAACAGGAAGTCCTTATAAATTAAGAGTTGTTGGAAAAAATTTCTTTAAGGAATTCTATGGGACAATAGCAGA
AATTCAGGAACAAGATAAAGAACTTGGATATTTTTTCTCACCACACAAGTCATACCTATCTAATATTAGCAATATTAGTG
GATACGACAAAAAGACAAAAGATGTTTTGTATTATGATGGTCATCGTTCACCAATTTCTCGATTACGTGTCAGATATTTA
AAAGAAATACTGAAAGCAAAAAGTAAAAAAGAAGAAAATAAAAAATAA

Domains

Predicted by InterproScan.

• LytTr DNA-binding domain (LytTR) (151-244)

• Response regulator receiver domain (Response_reg) (3-121)

3D structure

• AlphaFold DB: P75031

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/comE2	Streptococcus gordonii strain NCTC7865	100	100	1
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	100	100	1
comE	Streptococcus infantis strain Atu-4	64	98.039	0.627
comE	Streptococcus mitis NCTC 12261	64	98.039	0.627
comE	Streptococcus mitis SK321	63.2	98.039	0.62
comE	Streptococcus pneumoniae Rx1	62.8	98.039	0.616
comE	Streptococcus pneumoniae D39	62.8	98.039	0.616
comE	Streptococcus pneumoniae R6	62.8	98.039	0.616
comE	Streptococcus pneumoniae TIGR4	62.8	98.039	0.616
comE/blpR	Streptococcus mutans UA159	37.551	96.078	0.361