Detailed information    

insolico Bioinformatically predicted

Overview

Name   htrA   Type   Regulator
Locus tag   WH25_RS00930 Genome accession   NZ_CP017295
Coordinates   172325..173518 (+) Length   397 a.a.
NCBI ID   WP_046164771.1    Uniprot ID   -
Organism   Streptococcus gordonii strain IE35     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 167325..178518
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  WH25_RS00890 (WH25_00890) ychF 167627..168742 (-) 1116 WP_008808030.1 redox-regulated ATPase YchF -
  WH25_RS00905 (WH25_00905) comE/comE2 169064..169831 (-) 768 WP_008808031.1 competence system response regulator transcription factor ComE Regulator
  WH25_RS00910 (WH25_00910) comD/comD2 169828..171186 (-) 1359 WP_046165176.1 competence system sensor histidine kinase ComD Regulator
  WH25_RS10570 comC/comC1 171202..171366 (-) 165 WP_080998577.1 bacteriocin Regulator
  WH25_RS00925 (WH25_00925) rlmH 171652..172131 (-) 480 WP_008808034.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  WH25_RS00930 (WH25_00930) htrA 172325..173518 (+) 1194 WP_046164771.1 S1C family serine protease Regulator
  WH25_RS00935 (WH25_00935) spo0J 173584..174348 (+) 765 WP_046164772.1 ParB/RepB/Spo0J family partition protein Regulator
  WH25_RS00940 (WH25_00940) dnaA 174552..175904 (+) 1353 WP_008808037.1 chromosomal replication initiator protein DnaA -
  WH25_RS00945 (WH25_00945) dnaN 176060..177196 (+) 1137 WP_046164773.1 DNA polymerase III subunit beta -
  WH25_RS00950 (WH25_00950) - 177196..177399 (+) 204 WP_008808039.1 DUF951 domain-containing protein -
  WH25_RS00955 (WH25_00955) - 177418..177936 (-) 519 WP_052721530.1 YehR family protein -

Sequence

Protein


Download         Length: 397 a.a.        Molecular weight: 42165.85 Da        Isoelectric Point: 5.4898

>NTDB_id=197398 WH25_RS00930 WP_046164771.1 172325..173518(+) (htrA) [Streptococcus gordonii strain IE35]
MKNSSNFFKKTLQVFIVLLVGFIGGVAGTWGFSYFSTPHSAANNNQKTATTITTSYKNSNSTTKAVDKVKDAVVSVITYS
ESNSDAIFDNNNSGNENDQVASEGSGVIYRKDKDYAYLVTNTHVINGAKKVDIRLADGNKVPGEIVGTDTYSDISVVRIP
ADKVKNVAEFGDSSKLTVGETAIAIGSPLGSDYANTVTQGIVSSLSRNVSSRSEDGQTIATQAIQTDAAINPGNSGGPLV
NIQGQVIGITSSKIANTNNGSTSVEGMGFAIPSNDVVNIIEQLEKNGKVIRPALGIQMVNLSSLSSSSSDRLKLPDNVKN
GVVVRSTQTGMPADGKLQKYDVITKIDDTEISSASDIQSALYKHSINEEIKVTYYRDGKEQTTTIKLTKSTDDLSSE

Nucleotide


Download         Length: 1194 bp        

>NTDB_id=197398 WH25_RS00930 WP_046164771.1 172325..173518(+) (htrA) [Streptococcus gordonii strain IE35]
ATGAAAAACTCTTCAAATTTCTTCAAAAAAACATTGCAAGTTTTCATTGTTTTGTTAGTTGGTTTTATAGGTGGTGTTGC
TGGAACATGGGGATTTTCTTATTTTTCAACACCTCATTCAGCCGCAAATAATAATCAGAAAACAGCAACTACAATAACAA
CATCCTATAAAAATAGTAATTCTACAACAAAGGCTGTTGATAAAGTAAAAGACGCGGTTGTCTCTGTCATTACATATTCT
GAATCTAATTCAGATGCTATTTTTGACAACAATAATTCAGGAAATGAAAATGATCAGGTAGCTAGCGAAGGATCTGGTGT
TATCTATAGAAAAGATAAAGACTATGCTTACTTAGTTACCAATACACACGTTATCAATGGTGCAAAAAAAGTTGATATCC
GTCTTGCTGATGGGAATAAGGTTCCTGGTGAAATAGTCGGGACTGATACATATTCTGATATTTCTGTAGTCAGAATTCCT
GCCGATAAAGTAAAAAATGTAGCAGAATTTGGGGATTCTAGTAAATTAACTGTTGGGGAAACTGCCATTGCAATCGGAAG
TCCTCTTGGATCTGATTATGCTAATACAGTGACTCAGGGAATTGTTTCCAGCCTAAGCCGTAATGTTTCTTCACGATCAG
AAGATGGTCAAACAATTGCTACTCAAGCTATTCAAACTGATGCAGCAATTAATCCAGGTAACTCTGGTGGTCCTCTTGTA
AACATTCAAGGTCAAGTTATTGGTATTACCTCTAGTAAAATTGCTAACACCAATAATGGCAGTACTTCTGTTGAAGGTAT
GGGATTTGCAATCCCATCCAATGATGTTGTAAATATCATTGAACAATTAGAAAAGAATGGTAAAGTCATTCGACCAGCAT
TAGGAATTCAAATGGTCAACTTAAGTAGTTTATCTTCTTCAAGCTCTGATCGATTAAAACTTCCAGACAATGTTAAAAAT
GGTGTCGTTGTTCGTTCCACACAAACTGGAATGCCTGCTGATGGTAAGTTACAAAAATATGATGTGATTACAAAAATTGA
TGATACAGAAATATCATCTGCTAGCGATATCCAATCAGCTCTTTATAAACATTCAATTAATGAAGAAATTAAAGTTACTT
ATTATCGTGATGGAAAAGAGCAAACAACAACTATTAAACTAACTAAATCGACTGATGATTTAAGTTCTGAATAA

Domains

Predicted by InterproScan.

Peptidase family M50 (Peptidase_M50)

(236-391)

PDZ domain (PDZ_2)

(292-387)

Trypsin-like peptidase domain (Trypsin_2)

(104-249)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  htrA Streptococcus gordonii str. Challis substr. CH1

98.992

100

0.99
  htrA Streptococcus mitis NCTC 12261

66.08

100

0.662
  htrA Streptococcus pneumoniae Rx1

66.162

99.748

0.66
  htrA Streptococcus pneumoniae D39

66.162

99.748

0.66
  htrA Streptococcus pneumoniae R6

66.162

99.748

0.66
  htrA Streptococcus pneumoniae TIGR4

66.162

99.748

0.66
  htrA Streptococcus mutans UA159

56.14

100

0.564

Multiple sequence alignment