Detailed information NTG0155992

Bioinformatically predicted

Overview

• Name: comE
• Type: Regulator
• Locus tag: RN80_RS02045
• Genome accession: NZ_CP012646
• Coordinates: 384972..385724 (+)
• Length: 250 a.a.
• NCBI ID: WP_000866073.1
• Uniprot ID: A0A081S8D7
• Organism: Streptococcus mitis strain KCOM 1350 (= ChDC B183)
• Function: activate transcription of early competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 379972..390724

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
RN80_RS02015 (RN80_02025)	spo0J	380573..381331 (-)	759	WP_060627320.1	ParB/RepB/Spo0J family partition protein	Regulator
RN80_RS02020 (RN80_02030)	htrA	381389..382570 (-)	1182	WP_060627321.1	S1C family serine protease	Regulator
RN80_RS02025 (RN80_02035)	rlmH	382754..383233 (+)	480	WP_060627322.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
RN80_RS02035 (RN80_02045)	comC/comC2	383515..383637 (+)	123	WP_060627323.1	competence-stimulating peptide ComC	Regulator
RN80_RS02040 (RN80_02050)	comD/comD1	383650..384975 (+)	1326	WP_060627324.1	competence system sensor histidine kinase ComD	Regulator
RN80_RS02045 (RN80_02055)	comE	384972..385724 (+)	753	WP_000866073.1	competence system response regulator transcription factor ComE	Regulator
RN80_RS02060 (RN80_02070)	-	385967..386509 (-)	543	WP_001158273.1	TetR/AcrR family transcriptional regulator	-
RN80_RS02065 (RN80_02075)	-	386637..389279 (+)	2643	WP_060627325.1	YhgE/Pip domain-containing protein	-

Sequence

Protein

• Length: 250 a.a.
• Molecular weight: 29947.32 Da
• Isoelectric Point: 6.9819

>NTDB_id=155992 RN80_RS02045 WP_000866073.1 384972..385724(+) (comE) [Streptococcus mitis strain KCOM 1350 (= ChDC B183)]
MKVLILEDVIEHQVRLERILDEISKESNIPISYKTTGKVREFKEYIENDEVNQLYFLDIDIHGIEKKGFEVAQFIRHHNP
YAIIVFITSRSEFATLTYKYQVSALDFVDKDINDELFKKRIEQNIFYTKSMLLENEDVVDYFDYNYKGNDLKIPYHDILY
IETTGVSHKLRIIGKNFAKEFYGTMTDIQEKDKHTQRFYSPHKSFLVNIGNIREIDRKNLEIVFYEDHRCPISRLKIRKL
KDILEKKSQK

Nucleotide

• Length: 753 bp

>NTDB_id=155992 RN80_RS02045 WP_000866073.1 384972..385724(+) (comE) [Streptococcus mitis strain KCOM 1350 (= ChDC B183)]
ATGAAAGTTTTGATTTTAGAAGATGTTATTGAACATCAAGTGAGACTAGAGAGAATATTGGATGAAATTTCGAAAGAATC
GAATATTCCAATATCATACAAGACAACGGGAAAAGTTCGTGAATTTAAGGAATATATCGAAAATGATGAAGTAAACCAGC
TTTATTTTCTAGATATTGATATTCATGGAATTGAGAAAAAAGGGTTTGAAGTTGCTCAGTTTATTCGTCATCACAATCCT
TACGCTATTATCGTCTTTATCACAAGTCGATCAGAGTTTGCTACTCTAACCTATAAATACCAGGTATCAGCTCTAGATTT
TGTTGATAAGGATATTAATGATGAGTTATTTAAGAAGAGAATTGAGCAAAATATCTTCTACACGAAGAGTATGTTACTTG
AAAATGAAGATGTGGTAGATTATTTTGACTACAATTACAAGGGAAATGATTTAAAAATTCCTTATCATGACATTCTGTAT
ATTGAAACGACAGGAGTTTCTCATAAATTGCGCATTATTGGTAAGAATTTTGCAAAAGAATTTTATGGTACCATGACAGA
TATTCAGGAAAAGGACAAACATACTCAGCGATTTTATTCTCCTCATAAGTCATTTTTGGTAAATATAGGCAATATCAGAG
AAATTGATCGAAAAAACCTAGAAATTGTTTTCTATGAAGACCATCGTTGTCCTATTTCAAGATTAAAAATTAGAAAATTG
AAAGATATTCTAGAGAAAAAATCTCAAAAGTAA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (3-121)

• LytTr DNA-binding domain (LytTR) (151-244)

3D structure

• AlphaFold DB: A0A081S8D7

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE	Streptococcus mitis NCTC 12261	100	100	1
comE	Streptococcus mitis SK321	99.2	100	0.992
comE	Streptococcus pneumoniae Rx1	98.4	100	0.984
comE	Streptococcus pneumoniae D39	98.4	100	0.984
comE	Streptococcus pneumoniae R6	98.4	100	0.984
comE	Streptococcus pneumoniae TIGR4	98.4	100	0.984
comE	Streptococcus infantis strain Atu-4	92.8	100	0.928
comE/comE2	Streptococcus gordonii strain NCTC7865	64	100	0.64
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	64	100	0.64
comE/blpR	Streptococcus mutans UA159	41.7	98.8	0.412