Detailed information    

insolico Bioinformatically predicted

Overview

Name   comD/comD1   Type   Regulator
Locus tag   RN80_RS02040 Genome accession   NZ_CP012646
Coordinates   383650..384975 (+) Length   441 a.a.
NCBI ID   WP_060627324.1    Uniprot ID   -
Organism   Streptococcus mitis strain KCOM 1350 (= ChDC B183)     
Function   phosphorylation of ComE (predicted from homology)   
Competence regulation

Genomic Context

Location: 378650..389975
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  RN80_RS02010 (RN80_02020) dnaA 378999..380360 (-) 1362 WP_060627319.1 chromosomal replication initiator protein DnaA -
  RN80_RS02015 (RN80_02025) spo0J 380573..381331 (-) 759 WP_060627320.1 ParB/RepB/Spo0J family partition protein Regulator
  RN80_RS02020 (RN80_02030) htrA 381389..382570 (-) 1182 WP_060627321.1 S1C family serine protease Regulator
  RN80_RS02025 (RN80_02035) rlmH 382754..383233 (+) 480 WP_060627322.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  RN80_RS02035 (RN80_02045) comC/comC2 383515..383637 (+) 123 WP_060627323.1 competence-stimulating peptide ComC Regulator
  RN80_RS02040 (RN80_02050) comD/comD1 383650..384975 (+) 1326 WP_060627324.1 competence system sensor histidine kinase ComD Regulator
  RN80_RS02045 (RN80_02055) comE 384972..385724 (+) 753 WP_000866073.1 competence system response regulator transcription factor ComE Regulator
  RN80_RS02060 (RN80_02070) - 385967..386509 (-) 543 WP_001158273.1 TetR/AcrR family transcriptional regulator -
  RN80_RS02065 (RN80_02075) - 386637..389279 (+) 2643 WP_060627325.1 YhgE/Pip domain-containing protein -

Sequence

Protein


Download         Length: 441 a.a.        Molecular weight: 51187.75 Da        Isoelectric Point: 7.0707

>NTDB_id=155991 RN80_RS02040 WP_060627324.1 383650..384975(+) (comD/comD1) [Streptococcus mitis strain KCOM 1350 (= ChDC B183)]
MNFFLVVDFILYFFIISHSYHLICKGQINRKELFFFGAYTLLVEVVLGLPFYLLNLDGLGIARFLFPLGLYSYFRWIKQY
ERDRGLFLSLLLSLLYESTHNFLSVTFSSITGDNFVLQYYGLFFFVVTVLTYVVIVTIIHYFHLELAYFDKDYLYPFLKK
VFFALLLLHIVSFVSNMVSTIKHLNSFGSILSSIVFISLLLTFFAMNSHKVQMEKEIALKQKKFEQKHLQNYTDEIVGLY
NEIRGFRHDYAGMLVSMQMAIDSGDLQEIDRVYNEVLVKANHKLRSDKYTYFDLNNIEDSALRSLVAQSIVYARNNGVEF
TLEVKDTITKLPIELLDLVRIMSVLLNNAVEGSADSYKKQMEVAVIKMETETVIVIQNSCKMTMTPSGDLFALGFSTKGR
NRGVGLNNVKELLDKYNNIILETEMEGSTFRQIIRFKREFE

Nucleotide


Download         Length: 1326 bp        

>NTDB_id=155991 RN80_RS02040 WP_060627324.1 383650..384975(+) (comD/comD1) [Streptococcus mitis strain KCOM 1350 (= ChDC B183)]
ATGAATTTTTTCTTAGTAGTAGATTTTATATTATATTTTTTTATTATTAGTCACAGTTACCATTTAATTTGTAAAGGTCA
AATAAATAGAAAAGAATTATTCTTTTTTGGTGCTTATACATTACTAGTAGAAGTAGTACTTGGCCTTCCCTTCTATCTTC
TAAATTTAGATGGGTTAGGGATTGCAAGATTTTTATTTCCTTTGGGCTTATATTCCTATTTTCGATGGATTAAACAGTAT
GAGAGGGATAGAGGACTATTCCTAAGTTTACTACTATCTCTTTTATATGAGAGCACTCATAACTTTCTGTCCGTAACGTT
CTCCTCTATAACAGGAGACAATTTTGTTTTACAATATTATGGCCTATTCTTTTTCGTTGTAACGGTATTGACTTATGTCG
TTATCGTAACAATCATTCATTATTTCCATTTGGAACTAGCCTATTTTGACAAGGACTACCTTTATCCTTTCTTGAAAAAA
GTATTTTTTGCTTTACTACTGCTCCATATTGTATCTTTCGTTTCAAATATGGTAAGTACGATTAAACATTTGAATAGCTT
TGGAAGTATTTTATCATCTATTGTCTTTATCTCTTTACTTTTGACCTTCTTTGCAATGAATTCTCATAAAGTTCAAATGG
AGAAAGAGATTGCTTTGAAGCAGAAGAAATTTGAACAGAAACATTTACAGAATTATACAGATGAAATTGTCGGTCTGTAT
AATGAAATCCGTGGTTTTCGACATGATTATGCTGGGATGCTTGTCAGTATGCAAATGGCAATTGACAGTGGTGATTTACA
GGAAATTGACAGAGTTTACAATGAAGTTTTGGTCAAAGCAAATCACAAATTGCGTTCAGATAAGTACACTTACTTTGATT
TAAACAATATAGAAGATTCAGCTTTACGAAGTTTGGTTGCTCAGTCCATTGTCTATGCTCGAAATAATGGTGTAGAGTTT
ACACTGGAAGTAAAAGATACGATTACCAAGCTCCCAATTGAATTATTGGATTTGGTTCGTATCATGAGCGTTTTATTGAA
CAATGCTGTCGAAGGATCGGCTGATAGTTATAAAAAGCAGATGGAAGTAGCAGTTATTAAGATGGAAACTGAAACAGTGA
TTGTGATTCAGAATTCATGTAAAATGACGATGACTCCTTCAGGAGATCTATTTGCTTTAGGATTCTCTACTAAGGGAAGA
AATCGCGGAGTAGGATTAAATAATGTGAAAGAACTACTAGATAAGTACAATAATATTATTTTAGAAACAGAGATGGAAGG
CAGTACATTTAGACAAATCATTAGATTTAAGAGGGAATTTGAATGA

Domains

Predicted by InterproScan.

GHKL domain (HATPase_c_5)

(334-434)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comD/comD1 Streptococcus pneumoniae Rx1

92.29

100

0.923
  comD/comD1 Streptococcus pneumoniae D39

92.29

100

0.923
  comD/comD1 Streptococcus pneumoniae R6

92.29

100

0.923
  comD/comD2 Streptococcus pneumoniae TIGR4

93.287

97.959

0.914
  comD Streptococcus mitis SK321

91.383

100

0.914
  comD Streptococcus mitis NCTC 12261

88.435

100

0.884
  comD/comD1 Streptococcus gordonii str. Challis substr. CH1

49.202

85.261

0.42
  comD/comD2 Streptococcus gordonii strain NCTC7865

48.936

85.261

0.417

Multiple sequence alignment