Detailed information    

insolico Bioinformatically predicted

Overview

Name   htrA   Type   Regulator
Locus tag   RN80_RS02020 Genome accession   NZ_CP012646
Coordinates   381389..382570 (-) Length   393 a.a.
NCBI ID   WP_060627321.1    Uniprot ID   -
Organism   Streptococcus mitis strain KCOM 1350 (= ChDC B183)     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 376389..387570
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  RN80_RS02000 (RN80_02010) - 377445..377639 (-) 195 WP_000285186.1 DUF951 domain-containing protein -
  RN80_RS02005 (RN80_02015) dnaN 377704..378840 (-) 1137 WP_060627318.1 DNA polymerase III subunit beta -
  RN80_RS02010 (RN80_02020) dnaA 378999..380360 (-) 1362 WP_060627319.1 chromosomal replication initiator protein DnaA -
  RN80_RS02015 (RN80_02025) spo0J 380573..381331 (-) 759 WP_060627320.1 ParB/RepB/Spo0J family partition protein Regulator
  RN80_RS02020 (RN80_02030) htrA 381389..382570 (-) 1182 WP_060627321.1 S1C family serine protease Regulator
  RN80_RS02025 (RN80_02035) rlmH 382754..383233 (+) 480 WP_060627322.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  RN80_RS02035 (RN80_02045) comC/comC2 383515..383637 (+) 123 WP_060627323.1 competence-stimulating peptide ComC Regulator
  RN80_RS02040 (RN80_02050) comD/comD1 383650..384975 (+) 1326 WP_060627324.1 competence system sensor histidine kinase ComD Regulator
  RN80_RS02045 (RN80_02055) comE 384972..385724 (+) 753 WP_000866073.1 competence system response regulator transcription factor ComE Regulator
  RN80_RS02060 (RN80_02070) - 385967..386509 (-) 543 WP_001158273.1 TetR/AcrR family transcriptional regulator -

Sequence

Protein


Download         Length: 393 a.a.        Molecular weight: 41679.52 Da        Isoelectric Point: 6.1486

>NTDB_id=155989 RN80_RS02020 WP_060627321.1 381389..382570(-) (htrA) [Streptococcus mitis strain KCOM 1350 (= ChDC B183)]
MKHLKTFYKKGFQLLVVIVISFISGALGSFSINQLTQKSTVSTSNNNSTITQTAYKNENSTTQAVNKVKDAVVSVITYSA
NRQNSVFGNDDTDTDSQQISSEGSGVIYKKNDKEAYIVTNNHVINGASKVDIRLSDGTKVPGEIVGADTFSDIAVVKISS
EKVTTVAEFGDSSKLTVGETAIAIGSPLGSEYANTVTQGIVSSLNRNVSLKSEDGQAISTKAIQTDTAINPGNSGGPLIN
IQGQVIGITSSKIATNGGTSVEGLGFAIPANDAINIIEQLEKNGKVTRPALGIQMVNLSNINTSDIRRLNIPSNVTSGVV
VRSVQSNMPANGHLEKYDVITKIDDKEIASSTDLQSALYNHSIGDTIKITYYRNGKEETTSIKLDKSSGDLES

Nucleotide


Download         Length: 1182 bp        

>NTDB_id=155989 RN80_RS02020 WP_060627321.1 381389..382570(-) (htrA) [Streptococcus mitis strain KCOM 1350 (= ChDC B183)]
ATGAAACATTTAAAAACATTTTACAAAAAAGGGTTTCAATTATTAGTCGTTATCGTCATTAGCTTTATTAGTGGAGCCTT
GGGTAGCTTTTCAATAAACCAACTAACTCAAAAAAGTACTGTAAGTACCTCTAACAACAATAGTACTATTACACAGACTG
CCTATAAGAATGAAAATTCAACAACACAGGCTGTTAACAAAGTAAAAGATGCTGTTGTTTCAGTTATTACTTATTCAGCA
AACAGACAAAATAGCGTATTTGGTAATGATGATACTGACACAGATTCTCAGCAGATCTCTAGTGAAGGATCTGGGGTTAT
TTATAAAAAGAATGATAAAGAAGCTTATATTGTCACCAATAATCACGTTATAAATGGCGCCAGCAAAGTAGATATTCGTT
TGTCAGATGGAACTAAAGTACCTGGAGAAATCGTCGGAGCTGATACTTTCTCTGATATTGCTGTCGTCAAAATCTCTTCA
GAAAAAGTGACAACAGTAGCTGAATTTGGTGATTCTAGTAAGCTAACCGTAGGAGAAACTGCTATTGCCATTGGTAGCCC
GTTAGGTTCTGAATATGCTAATACTGTCACTCAAGGTATCGTATCTAGTCTTAATCGAAATGTGTCCTTAAAATCTGAAG
ATGGACAAGCCATTTCTACAAAAGCCATCCAAACTGATACTGCTATTAACCCAGGTAACTCTGGTGGTCCACTAATCAAT
ATTCAAGGACAGGTTATCGGAATTACCTCAAGTAAAATTGCCACAAATGGAGGAACATCTGTAGAAGGTCTTGGTTTTGC
AATCCCTGCAAATGATGCTATCAATATTATTGAACAGTTAGAAAAGAACGGAAAAGTAACGCGTCCAGCTTTGGGAATTC
AAATGGTCAATCTCTCAAATATTAATACAAGTGATATTAGAAGACTGAATATTCCAAGCAATGTAACATCTGGTGTAGTT
GTTCGTTCTGTGCAGAGCAATATGCCTGCCAATGGTCACCTTGAAAAATACGATGTTATTACAAAAATAGATGATAAGGA
GATTGCTTCATCAACAGATTTACAAAGTGCTCTTTACAATCATTCTATCGGAGACACCATTAAGATAACTTACTATCGTA
ACGGTAAAGAAGAAACTACATCTATTAAACTTGACAAGAGTTCAGGTGATTTAGAATCTTAA

Domains

Predicted by InterproScan.

PDZ domain (PDZ_2)

(289-384)

Trypsin-like peptidase domain (Trypsin_2)

(103-248)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  htrA Streptococcus mitis NCTC 12261

99.237

100

0.992
  htrA Streptococcus pneumoniae Rx1

96.947

100

0.969
  htrA Streptococcus pneumoniae D39

96.947

100

0.969
  htrA Streptococcus pneumoniae R6

96.947

100

0.969
  htrA Streptococcus pneumoniae TIGR4

96.947

100

0.969
  htrA Streptococcus gordonii str. Challis substr. CH1

67.003

100

0.677
  htrA Streptococcus mutans UA159

54.822

100

0.55

Multiple sequence alignment