Detailed information NTG0121186

Bioinformatically predicted

Overview

• Name: comE
• Type: Regulator
• Locus tag: DK43_RS00125
• Genome accession: NZ_CP007573
• Coordinates: 25760..26509 (+)
• Length: 249 a.a.
• NCBI ID: WP_003029521.1
• Uniprot ID: A0A4V0A713
• Organism: Streptococcus anginosus strain SA1
• Function: activate transcription of early competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 20760..31509

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DK43_RS00095 (DK43_00100)	spo0J	21305..22072 (-)	768	WP_003029516.1	ParB/RepB/Spo0J family partition protein	Regulator
DK43_RS00100 (DK43_00105)	htrA	22127..23317 (-)	1191	WP_003029517.1	trypsin-like peptidase domain-containing protein	Regulator
DK43_RS00105 (DK43_00110)	rlmH	23510..23989 (+)	480	WP_003029518.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
DK43_RS09895 (DK43_00120)	-	24271..24417 (+)	147	WP_003029519.1	bacteriocin	-
DK43_RS00120 (DK43_00125)	comD/comD2	24435..25760 (+)	1326	WP_218015592.1	GHKL domain-containing protein	Regulator
DK43_RS00125 (DK43_00130)	comE	25760..26509 (+)	750	WP_003029521.1	competence system response regulator transcription factor ComE	Regulator
DK43_RS09900 (DK43_00145)	-	26978..27811 (+)	834	WP_022525263.1	ISL3 family transposase	-
DK43_RS00145 (DK43_00150)	-	27855..30431 (-)	2577	WP_003027897.1	YfhO family protein	-

Sequence

Protein

• Length: 249 a.a.
• Molecular weight: 29216.88 Da
• Isoelectric Point: 8.6042

>NTDB_id=121186 DK43_RS00125 WP_003029521.1 25760..26509(+) (comE) [Streptococcus anginosus strain SA1]
MKVLVLEDEISHQVRMETTLAEIAKEMGITIKVKVTGKVREFKEYIENDEVNQLYFLDIDIKGEETKGLEIAKFIRHHNP
YAIIVFVTTKSEFATMTFKYKVSALDFVDKNLSDIAFKKHIKDSIEYTKATLIENKDMVDYFEYSFRGGEVRMPFNDILY
IETTGSSHKLRIVGKNFFKEFYGTIADIQEKDKETRRFFSPHKSYLVNIGNIKGYDKKMREIIFYEDHRCPITRMKIGKL
KAILEELKG

Nucleotide

• Length: 750 bp

>NTDB_id=121186 DK43_RS00125 WP_003029521.1 25760..26509(+) (comE) [Streptococcus anginosus strain SA1]
ATGAAAGTATTAGTATTAGAAGATGAAATTTCACATCAAGTAAGAATGGAAACAACTTTGGCAGAGATTGCGAAAGAAAT
GGGAATTACGATAAAAGTTAAAGTAACTGGCAAAGTAAGAGAATTTAAAGAATATATTGAAAATGATGAGGTGAATCAAT
TATATTTTTTAGATATTGATATCAAAGGAGAGGAAACAAAAGGTTTAGAAATAGCAAAATTTATACGTCATCACAATCCG
TATGCTATTATTGTTTTTGTTACAACGAAATCAGAATTTGCTACGATGACATTTAAATATAAAGTATCTGCACTGGATTT
TGTTGATAAAAATTTGAGTGATATTGCTTTTAAAAAACATATAAAAGACAGCATTGAGTATACAAAAGCGACATTGATTG
AAAATAAAGATATGGTGGATTATTTTGAATATAGCTTTCGTGGCGGAGAGGTTAGAATGCCTTTTAATGACATTTTATAT
ATTGAAACGACAGGCTCTTCTCATAAATTAAGAATTGTCGGTAAAAACTTTTTTAAAGAATTTTATGGTACTATTGCAGA
TATTCAAGAAAAAGATAAAGAAACAAGACGTTTCTTTTCACCTCATAAATCTTATCTAGTCAATATTGGAAACATCAAAG
GTTATGACAAAAAAATGCGAGAAATAATTTTTTATGAAGATCATCGTTGTCCGATTACTCGAATGAAAATTGGAAAGTTA
AAGGCTATTTTAGAGGAATTAAAAGGATAA

Domains

Predicted by InterproScan.

• LytTr DNA-binding domain (LytTR) (152-244)

• Response regulator receiver domain (Response_reg) (3-121)

3D structure

• AlphaFold DB: A0A4V0A713

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE	Streptococcus mitis NCTC 12261	70.612	98.394	0.695
comE/comE2	Streptococcus gordonii strain NCTC7865	70.492	97.992	0.691
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	70.492	97.992	0.691
comE	Streptococcus infantis strain Atu-4	69.796	98.394	0.687
comE	Streptococcus mitis SK321	69.796	98.394	0.687
comE	Streptococcus pneumoniae Rx1	69.388	98.394	0.683
comE	Streptococcus pneumoniae D39	69.388	98.394	0.683
comE	Streptococcus pneumoniae R6	69.388	98.394	0.683
comE	Streptococcus pneumoniae TIGR4	69.388	98.394	0.683
comE/blpR	Streptococcus mutans UA159	40.486	99.197	0.402
comE/comE2	Streptococcus equinus JB1	35.019	100	0.361