Detailed information    

insolico Bioinformatically predicted

Overview

Name   htrA   Type   Regulator
Locus tag   DK43_RS00100 Genome accession   NZ_CP007573
Coordinates   22127..23317 (-) Length   396 a.a.
NCBI ID   WP_003029517.1    Uniprot ID   A0AAI9J965
Organism   Streptococcus anginosus strain SA1     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 17127..28317
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  DK43_RS00075 (DK43_00080) - 17720..18220 (+) 501 WP_003029510.1 YehR family protein -
  DK43_RS00080 (DK43_00085) - 18244..18441 (-) 198 WP_003029511.1 DUF951 family protein -
  DK43_RS00085 (DK43_00090) dnaN 18441..19577 (-) 1137 WP_003029513.1 DNA polymerase III subunit beta -
  DK43_RS00090 (DK43_00095) dnaA 19734..21077 (-) 1344 WP_003029515.1 chromosomal replication initiator protein DnaA -
  DK43_RS00095 (DK43_00100) spo0J 21305..22072 (-) 768 WP_003029516.1 ParB/RepB/Spo0J family partition protein Regulator
  DK43_RS00100 (DK43_00105) htrA 22127..23317 (-) 1191 WP_003029517.1 trypsin-like peptidase domain-containing protein Regulator
  DK43_RS00105 (DK43_00110) rlmH 23510..23989 (+) 480 WP_003029518.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  DK43_RS09895 (DK43_00120) - 24271..24417 (+) 147 WP_003029519.1 bacteriocin -
  DK43_RS00120 (DK43_00125) comD/comD2 24435..25760 (+) 1326 WP_218015592.1 GHKL domain-containing protein Regulator
  DK43_RS00125 (DK43_00130) comE 25760..26509 (+) 750 WP_003029521.1 competence system response regulator transcription factor ComE Regulator
  DK43_RS09900 (DK43_00145) - 26978..27811 (+) 834 WP_022525263.1 ISL3 family transposase -

Sequence

Protein


Download         Length: 396 a.a.        Molecular weight: 41678.63 Da        Isoelectric Point: 9.4264

>NTDB_id=121184 DK43_RS00100 WP_003029517.1 22127..23317(-) (htrA) [Streptococcus anginosus strain SA1]
MKNSSNFTKKLLLLFMVLAIGFIGGLLGNLTSSKLSTNSSTTTKVNQVTTAYKNTNSTTQAVSKVKDAVVSVITYANNNS
QNSVFGNDDSNNNNDNSQQVASEGSGVIYKKDGKYAYLVTNTHVISGAKKVDIRLADGNKVPGEIVGSDTYSDISVVRIS
ADKVKSVAEFGDSSKLTVGETAIAIGSPLGSNYANTVTQGIISSLNRNVSLKSEDGQTISTQAIQTDTAINPGNSGGPLV
NIQGQVIGITSSKIANNGGTSVEGLGFAIPSNDVINIINQLEANGTVTRPALGIQMIDITNLSSSDLSRLKLPSKITSGV
VVRSAQSGMPAEGKLQKYDVITKVDDKEISSTSDLQSALYKHSIGDNIKITFYRDGKETTTTIKLTKSTKDLDSNN

Nucleotide


Download         Length: 1191 bp        

>NTDB_id=121184 DK43_RS00100 WP_003029517.1 22127..23317(-) (htrA) [Streptococcus anginosus strain SA1]
ATGAAAAACTCTTCAAATTTCACAAAAAAATTGTTATTGCTTTTCATGGTCTTAGCTATAGGTTTTATTGGTGGTTTACT
TGGAAACTTAACTTCATCTAAATTATCAACAAATAGCTCTACAACGACTAAAGTTAATCAAGTTACTACTGCTTATAAAA
ATACAAATTCCACAACACAAGCTGTGAGTAAAGTAAAAGATGCTGTTGTATCCGTTATTACCTATGCTAATAATAATTCA
CAAAACAGTGTGTTTGGAAATGATGATTCAAATAATAACAATGATAATTCTCAACAAGTAGCTAGCGAAGGGTCTGGAGT
TATTTATAAAAAAGATGGAAAATACGCTTACTTAGTAACCAATACTCACGTTATCAGTGGTGCTAAAAAAGTTGACATTC
GTTTAGCAGATGGTAATAAAGTTCCTGGAGAAATTGTAGGGTCAGATACTTATTCTGATATCTCCGTTGTTCGCATTAGT
GCTGATAAAGTAAAATCAGTTGCTGAATTTGGAGATTCTAGCAAATTGACTGTTGGTGAGACAGCTATTGCGATTGGAAG
TCCACTTGGTTCAAATTATGCTAATACTGTGACGCAAGGAATTATTTCTAGTTTAAATCGTAATGTTTCTCTAAAATCTG
AAGACGGACAAACGATTTCAACACAAGCTATTCAAACAGACACAGCTATTAACCCAGGGAACTCTGGTGGACCACTTGTG
AATATCCAAGGACAAGTAATTGGTATTACTTCAAGTAAAATAGCTAACAACGGCGGAACTTCGGTTGAAGGATTAGGATT
TGCTATTCCATCTAATGATGTTATAAACATTATTAACCAGTTAGAAGCAAATGGAACTGTTACACGACCAGCTCTAGGAA
TCCAAATGATTGACATCACTAATCTGTCTAGTTCAGATCTATCACGCTTAAAACTTCCATCAAAAATAACTAGTGGAGTT
GTCGTACGTTCAGCTCAATCTGGAATGCCAGCTGAAGGAAAACTTCAAAAATATGATGTGATTACAAAAGTAGATGATAA
AGAAATTTCTTCAACAAGTGATTTACAATCCGCTTTATACAAACATTCAATTGGTGACAACATAAAAATCACTTTCTATC
GTGATGGAAAAGAAACTACTACTACCATTAAGCTTACAAAATCTACAAAAGATTTAGATTCAAATAATTGA

Domains

Predicted by InterproScan.

Peptidase family M50 (Peptidase_M50)

(265-390)

Trypsin-like peptidase domain (Trypsin_2)

(104-249)

PDZ domain (PDZ_2)

(290-385)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  htrA Streptococcus gordonii str. Challis substr. CH1

75.81

100

0.768
  htrA Streptococcus mitis NCTC 12261

72.544

100

0.727
  htrA Streptococcus pneumoniae Rx1

72.292

100

0.725
  htrA Streptococcus pneumoniae D39

72.292

100

0.725
  htrA Streptococcus pneumoniae R6

72.292

100

0.725
  htrA Streptococcus pneumoniae TIGR4

72.292

100

0.725
  htrA Streptococcus mutans UA159

55.216

99.242

0.548

Multiple sequence alignment