Detailed information NTG1170074

Bioinformatically predicted

Overview

• Name: comE
• Type: Regulator
• Locus tag: ACLV7Q_RS10210
• Genome accession: NZ_OZ217341
• Coordinates: 2136549..2137301 (-)
• Length: 250 a.a.
• NCBI ID: WP_000866065.1
• Uniprot ID: -
• Organism: Streptococcus mitis isolate S. mitis C22
• Function: activate transcription of early competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2131549..2142301

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ACLV7Q_RS10190 (SMIC22_20160)	-	2132993..2135635 (-)	2643	WP_218757901.1	YhgE/Pip family protein	-
ACLV7Q_RS10195 (SMIC22_20170)	-	2135764..2136306 (+)	543	WP_057488235.1	TetR/AcrR family transcriptional regulator	-
ACLV7Q_RS10210 (SMIC22_20200)	comE	2136549..2137301 (-)	753	WP_000866065.1	competence system response regulator transcription factor ComE	Regulator
ACLV7Q_RS10215 (SMIC22_20210)	comD/comD1	2137298..2138623 (-)	1326	WP_218757900.1	GHKL domain-containing protein	Regulator
ACLV7Q_RS10220 (SMIC22_20220)	comC/comC1	2138644..2138769 (-)	126	WP_218757899.1	competence-stimulating peptide ComC	Regulator
ACLV7Q_RS10230 (SMIC22_20240)	rlmH	2139052..2139531 (-)	480	WP_084367488.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
ACLV7Q_RS10235 (SMIC22_20250)	htrA	2139715..2140896 (+)	1182	WP_176139267.1	S1C family serine protease	Regulator
ACLV7Q_RS10240 (SMIC22_20260)	spo0J	2140954..2141712 (+)	759	WP_218757898.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 250 a.a.
• Molecular weight: 29958.31 Da
• Isoelectric Point: 6.5073

>NTDB_id=1170074 ACLV7Q_RS10210 WP_000866065.1 2136549..2137301(-) (comE) [Streptococcus mitis isolate S. mitis C22]
MKVLILEDVIEHQVRLERILDEISKESNIPISYKTTGKVREFEEYIENDEVNQLYFLDIDIHGIEKKGFEVAQLIRHYNP
YAIIVFITSRSEFATLTYKYQVSALDFVDKDINDEMFKKRIEQNIFYTKSMLLENEDVVDYFDYNYKGNDLKIPYHDILY
IETTGVSHKLRIIGKNFAKEFYGTMTDIQEKDKHTQRFYSPHKSFLVNIGNIREIDRKNLEIVFYEDHRCPISRLKIRKL
KDILEKKSQK

Nucleotide

• Length: 753 bp

>NTDB_id=1170074 ACLV7Q_RS10210 WP_000866065.1 2136549..2137301(-) (comE) [Streptococcus mitis isolate S. mitis C22]
ATGAAAGTTTTAATTTTAGAAGATGTTATTGAACATCAAGTGAGACTAGAAAGAATATTGGATGAAATTTCGAAAGAATC
GAATATTCCAATATCATACAAGACAACGGGAAAAGTCCGTGAATTTGAAGAATACATTGAGAACGATGAAGTAAATCAGC
TTTATTTCCTAGATATCGATATTCATGGGATTGAGAAAAAGGGATTTGAAGTGGCTCAACTCATTCGTCATTACAATCCT
TACGCTATTATCGTCTTTATCACTAGTCGATCAGAGTTTGCGACTCTGACCTATAAATACCAGGTATCAGCCCTAGATTT
TGTTGATAAGGATATCAATGATGAGATGTTTAAGAAGAGAATTGAGCAAAATATCTTCTACACGAAGAGTATGTTACTTG
AAAATGAAGATGTTGTAGACTATTTTGACTACAATTACAAGGGAAATGATTTAAAAATCCCTTACCATGATATTTTGTAT
ATTGAAACGACAGGAGTCTCTCATAAATTGCGCATTATTGGTAAGAATTTTGCCAAAGAGTTTTACGGTACCATGACAGA
TATTCAGGAAAAGGACAAACATACTCAGCGATTTTATTCTCCTCATAAGTCATTTTTGGTAAATATAGGCAATATCAGAG
AGATTGATCGAAAAAACTTAGAAATTGTTTTCTATGAAGACCATCGTTGTCCTATTTCAAGATTAAAAATTAGAAAATTA
AAAGATATTTTAGAGAAAAAATCTCAAAAGTGA

Domains

Predicted by InterproScan.

• LytTr DNA-binding domain (LytTR) (151-244)

• Response regulator receiver domain (Response_reg) (3-121)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE	Streptococcus pneumoniae Rx1	100	100	1
comE	Streptococcus pneumoniae D39	100	100	1
comE	Streptococcus pneumoniae R6	100	100	1
comE	Streptococcus pneumoniae TIGR4	100	100	1
comE	Streptococcus mitis SK321	99.2	100	0.992
comE	Streptococcus mitis NCTC 12261	98.4	100	0.984
comE	Streptococcus infantis strain Atu-4	91.2	100	0.912
comE/comE2	Streptococcus gordonii strain NCTC7865	62.8	100	0.628
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	62.8	100	0.628
comE/blpR	Streptococcus mutans UA159	41.296	98.8	0.408