Detailed information NTG1170077

Bioinformatically predicted

Overview

• Name: htrA
• Type: Regulator
• Locus tag: ACLV7Q_RS10235
• Genome accession: NZ_OZ217341
• Coordinates: 2139715..2140896 (+)
• Length: 393 a.a.
• NCBI ID: WP_176139267.1
• Uniprot ID: -
• Organism: Streptococcus mitis isolate S. mitis C22
• Function: repress competence development (predicted from homology) Competence regulation

Genomic Context

Location: 2134715..2145896

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ACLV7Q_RS10195 (SMIC22_20170)	-	2135764..2136306 (+)	543	WP_057488235.1	TetR/AcrR family transcriptional regulator	-
ACLV7Q_RS10210 (SMIC22_20200)	comE	2136549..2137301 (-)	753	WP_000866065.1	competence system response regulator transcription factor ComE	Regulator
ACLV7Q_RS10215 (SMIC22_20210)	comD/comD1	2137298..2138623 (-)	1326	WP_218757900.1	GHKL domain-containing protein	Regulator
ACLV7Q_RS10220 (SMIC22_20220)	comC/comC1	2138644..2138769 (-)	126	WP_218757899.1	competence-stimulating peptide ComC	Regulator
ACLV7Q_RS10230 (SMIC22_20240)	rlmH	2139052..2139531 (-)	480	WP_084367488.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
ACLV7Q_RS10235 (SMIC22_20250)	htrA	2139715..2140896 (+)	1182	WP_176139267.1	S1C family serine protease	Regulator
ACLV7Q_RS10240 (SMIC22_20260)	spo0J	2140954..2141712 (+)	759	WP_218757898.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 393 a.a.
• Molecular weight: 41645.46 Da
• Isoelectric Point: 6.1486

>NTDB_id=1170077 ACLV7Q_RS10235 WP_176139267.1 2139715..2140896(+) (htrA) [Streptococcus mitis isolate S. mitis C22]
MKHLKTFYKKGFQLLVVIVISFFSGALGSFSIAQLTQKSSISNSNNNSTITQTAYKNENSTTQAVNKVKDAVVSVITYSA
NRQNSVFGNDETDTDSQQISSEGSGVIYKKNDKEAYIVTNNHVINGASKVDIRLSDGTKVPGEIVGADTFSDIAVVKISS
EKVTTVAEFGDSSKLTVGETAIAIGSPLGSEYANTVTQGIVSSLNRNVSLKSEDGQAISTKAIQTDTAINPGNSGGPLIN
IQGQVIGITSSKIATNGGTSVEGLGFAIPANDAINIIEQLEKNGKVTRPALGIQMVNLSNISTSDIRRLNIPSSVTSGVV
VRSVQSNMPANGHLEKYDVITKVDDKDITSSTDLQSALYNHSIGDTIKITYYRNGKEETTSIKLDKSSGDLES

Nucleotide

• Length: 1182 bp

>NTDB_id=1170077 ACLV7Q_RS10235 WP_176139267.1 2139715..2140896(+) (htrA) [Streptococcus mitis isolate S. mitis C22]
ATGAAACATTTAAAAACATTTTACAAAAAAGGGTTTCAATTATTAGTCGTTATCGTCATTAGCTTTTTTAGTGGAGCCTT
GGGTAGTTTTTCAATAGCTCAACTAACTCAAAAAAGTAGTATAAGCAACTCCAACAATAATAGCACTATCACACAAACTG
CCTATAAGAACGAAAATTCAACAACACAGGCTGTTAATAAAGTAAAAGATGCTGTTGTTTCTGTTATTACTTATTCAGCA
AACAGACAAAATAGCGTATTTGGCAATGATGAGACTGATACAGATTCTCAGCAAATCTCTAGTGAAGGATCGGGAGTTAT
TTATAAAAAGAATGATAAAGAAGCTTACATCGTCACCAATAATCACGTTATAAATGGCGCCAGCAAAGTAGATATTCGAT
TGTCAGATGGGACTAAAGTACCTGGAGAAATCGTCGGAGCGGATACTTTCTCTGATATTGCTGTCGTCAAAATCTCTTCA
GAAAAAGTGACAACAGTAGCTGAGTTTGGTGATTCTAGCAAGTTAACCGTAGGAGAAACTGCTATTGCTATTGGTAGCCC
ATTGGGTTCTGAATATGCAAATACTGTCACTCAAGGTATCGTATCTAGTCTTAATCGAAATGTATCTTTAAAATCTGAAG
ATGGACAAGCCATTTCTACAAAAGCCATCCAAACTGATACTGCTATTAACCCAGGTAACTCTGGTGGCCCACTAATCAAT
ATTCAAGGACAGGTTATCGGAATTACCTCAAGTAAAATTGCCACAAATGGAGGAACATCTGTAGAAGGCCTTGGTTTCGC
AATTCCTGCAAATGATGCTATCAATATTATTGAACAGTTAGAAAAGAACGGAAAAGTGACACGCCCAGCTTTGGGAATCC
AGATGGTTAATTTATCTAATATAAGTACAAGCGACATCAGAAGACTTAATATTCCAAGCAGTGTAACATCTGGTGTAGTT
GTTCGTTCTGTGCAAAGTAATATGCCTGCAAATGGTCACCTTGAAAAATACGATGTTATTACAAAAGTAGATGACAAAGA
CATTACTTCATCAACAGACTTACAAAGTGCTCTTTACAATCATTCTATCGGAGACACCATTAAGATCACTTACTATCGTA
ACGGTAAAGAAGAAACTACATCTATTAAACTTGACAAGAGTTCAGGTGATTTAGAATCTTAA

Domains

Predicted by InterproScan.

• PDZ domain (PDZ_2) (289-384)

• Trypsin-like peptidase domain (Trypsin_2) (103-248)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
htrA	Streptococcus mitis NCTC 12261	97.71	100	0.977
htrA	Streptococcus pneumoniae D39	96.947	100	0.969
htrA	Streptococcus pneumoniae R6	96.947	100	0.969
htrA	Streptococcus pneumoniae Rx1	96.947	100	0.969
htrA	Streptococcus pneumoniae TIGR4	96.947	100	0.969
htrA	Streptococcus gordonii str. Challis substr. CH1	66.162	100	0.667
htrA	Streptococcus mutans UA159	54.569	100	0.547