Detailed information    

insolico Bioinformatically predicted

Overview

Name   comD/comD1   Type   Regulator
Locus tag   ACLV7Q_RS10215 Genome accession   NZ_OZ217341
Coordinates   2137298..2138623 (-) Length   441 a.a.
NCBI ID   WP_218757900.1    Uniprot ID   -
Organism   Streptococcus mitis isolate S. mitis C22     
Function   phosphorylation of ComE (predicted from homology)   
Competence regulation

Genomic Context

Location: 2132298..2143623
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ACLV7Q_RS10190 (SMIC22_20160) - 2132993..2135635 (-) 2643 WP_218757901.1 YhgE/Pip family protein -
  ACLV7Q_RS10195 (SMIC22_20170) - 2135764..2136306 (+) 543 WP_057488235.1 TetR/AcrR family transcriptional regulator -
  ACLV7Q_RS10210 (SMIC22_20200) comE 2136549..2137301 (-) 753 WP_000866065.1 competence system response regulator transcription factor ComE Regulator
  ACLV7Q_RS10215 (SMIC22_20210) comD/comD1 2137298..2138623 (-) 1326 WP_218757900.1 GHKL domain-containing protein Regulator
  ACLV7Q_RS10220 (SMIC22_20220) comC/comC1 2138644..2138769 (-) 126 WP_218757899.1 competence-stimulating peptide ComC Regulator
  ACLV7Q_RS10230 (SMIC22_20240) rlmH 2139052..2139531 (-) 480 WP_084367488.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  ACLV7Q_RS10235 (SMIC22_20250) htrA 2139715..2140896 (+) 1182 WP_176139267.1 S1C family serine protease Regulator
  ACLV7Q_RS10240 (SMIC22_20260) spo0J 2140954..2141712 (+) 759 WP_218757898.1 ParB/RepB/Spo0J family partition protein Regulator

Sequence

Protein


Download         Length: 441 a.a.        Molecular weight: 50883.23 Da        Isoelectric Point: 6.8872

>NTDB_id=1170075 ACLV7Q_RS10215 WP_218757900.1 2137298..2138623(-) (comD/comD1) [Streptococcus mitis isolate S. mitis C22]
MNLLGFGTVIVYFLIISYSYHLICKGQVNRRELYVFGAYTLLTAIALDFPLYLLNLDGLGIATFLFPLGLYSYFRWIKQY
ERDRGLFLSLLLALLYESTHNFLSVTFSSITGDNFVLQYHDPFFFVVTVLTYVVILKIIHYFHLELAYFDKDYLYPFLKK
VLFALLLLHTASFVSDMVSTVKHLNSFGSILSSIVFISLLLTFFAMNSHKEQMEKEIALKQKKFEQKHLQNYTDEIVGLY
NEIRGFRHDYAGMLVSMQMAIDSGDLQEIDRVYNEVLVKANHKLRSDKYTYFDLNNIEDSALRSLVAQSIVYARNNGVEF
TLEVKDTITKLPIELLDLVRIMSVLLNNAVEGSADSYKKQMEVAVIKMETETVIVIQNSCKMTMTPSGDLFALGFSTKGR
NRGVGLNNVKELLNKYNNIILETEMEGSTFRQIIRFKREFE

Nucleotide


Download         Length: 1326 bp        

>NTDB_id=1170075 ACLV7Q_RS10215 WP_218757900.1 2137298..2138623(-) (comD/comD1) [Streptococcus mitis isolate S. mitis C22]
ATGAATTTGCTTGGATTTGGGACAGTTATTGTTTATTTTTTAATTATTAGTTACAGTTACCATTTAATTTGTAAAGGTCA
AGTAAATAGAAGAGAACTATACGTTTTTGGTGCTTATACATTACTAACAGCAATAGCACTTGATTTTCCCTTATATCTTC
TAAATTTAGATGGGTTAGGGATTGCAACATTTTTATTTCCTTTGGGCTTATATTCCTATTTTCGATGGATTAAACAGTAT
GAGAGGGATAGAGGATTATTCCTAAGTTTACTACTAGCACTTTTATATGAGAGCACTCATAACTTTCTGTCCGTAACTTT
CTCTTCTATAACAGGAGATAATTTTGTTTTACAATATCATGACCCATTCTTTTTCGTTGTAACGGTATTGACTTATGTTG
TTATCTTAAAAATCATTCATTATTTCCATCTAGAACTAGCCTATTTTGATAAGGACTACCTTTATCCTTTCTTGAAAAAA
GTATTGTTTGCTTTACTACTGCTCCATACTGCATCTTTCGTTTCAGATATGGTAAGTACGGTTAAACATTTGAATAGTTT
TGGAAGTATTTTGTCATCTATTGTCTTTATTTCTCTCCTTTTGACCTTCTTTGCAATGAATTCGCATAAAGAACAAATGG
AGAAAGAGATTGCTTTGAAGCAGAAGAAATTTGAACAGAAACATTTACAAAACTATACAGACGAAATTGTCGGACTGTAT
AATGAAATCCGTGGTTTTCGACATGACTATGCTGGAATGCTTGTCAGTATGCAGATGGCAATTGACAGTGGTGATTTACA
GGAAATTGACAGAGTTTACAATGAAGTTTTGGTCAAAGCCAATCATAAACTGCGTTCAGATAAGTACACTTACTTTGATT
TGAACAACATAGAAGATTCAGCTTTACGAAGTTTGGTTGCTCAGTCCATTGTCTATGCTCGAAATAATGGTGTAGAGTTT
ACACTGGAAGTAAAAGATACGATTACCAAGCTCCCAATCGAACTATTGGATTTGGTTCGTATCATGAGTGTTTTATTGAA
CAATGCTGTTGAAGGTTCAGCTGATAGCTATAAAAAGCAGATGGAAGTAGCAGTTATTAAGATGGAAACTGAAACAGTTA
TTGTGATTCAGAATTCATGTAAAATGACGATGACTCCTTCAGGAGATCTATTTGCCTTAGGATTCTCTACTAAGGGAAGA
AATCGCGGAGTCGGATTAAATAATGTAAAAGAACTACTAAATAAGTACAACAATATTATTTTAGAAACAGAGATGGAAGG
CAGTACATTTAGACAAATTATTAGATTTAAGAGGGAATTTGAATGA

Domains

Predicted by InterproScan.

GHKL domain (HATPase_c_5)

(334-434)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comD/comD1 Streptococcus pneumoniae Rx1

93.197

100

0.932
  comD/comD1 Streptococcus pneumoniae D39

93.197

100

0.932
  comD/comD1 Streptococcus pneumoniae R6

93.197

100

0.932
  comD/comD2 Streptococcus pneumoniae TIGR4

92.744

100

0.927
  comD Streptococcus mitis SK321

91.837

100

0.918
  comD Streptococcus mitis NCTC 12261

85.034

100

0.85
  comD/comD1 Streptococcus gordonii str. Challis substr. CH1

49.211

86.168

0.424
  comD/comD2 Streptococcus gordonii strain NCTC7865

48.947

86.168

0.422

Multiple sequence alignment