Detailed information NTG1130523

Bioinformatically predicted

Overview

• Name: comYC
• Type: Machinery gene
• Locus tag: H0501_RS08835
• Genome accession: NZ_LR822008
• Coordinates: 1716358..1716684 (-)
• Length: 108 a.a.
• NCBI ID: WP_002946126.1
• Uniprot ID: A0A0E2Q1B3
• Organism: Streptococcus thermophilus isolate STH_CIRM_18
• Function: dsDNA binding to the cell surface; assembly of the pseudopilus (predicted from homology) DNA binding and uptake

Genomic Context

Location: 1711358..1721684

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
H0501_RS10180 (STHERMO_1964)	-	1711624..1711962 (-)	339	WP_232086462.1	CPBP family intramembrane glutamic endopeptidase	-
H0501_RS10185 (STHERMO_1965)	-	1712006..1712281 (-)	276	WP_232086463.1	CAAX protease	-
H0501_RS08800 (STHERMO_1966)	-	1712293..1712490 (-)	198	WP_014727723.1	helix-turn-helix transcriptional regulator	-
H0501_RS08805 (STHERMO_1967)	-	1712739..1713932 (-)	1194	WP_179970807.1	acetate kinase	-
H0501_RS08810 (STHERMO_1968)	comYH	1713988..1714944 (-)	957	WP_084831205.1	class I SAM-dependent methyltransferase	Machinery gene
H0501_RS08815 (STHERMO_1969)	comGG	1714989..1715306 (-)	318	WP_082309152.1	competence type IV pilus minor pilin ComGG	-
H0501_RS08820 (STHERMO_1970)	comYF	1715284..1715721 (-)	438	WP_082309153.1	competence type IV pilus minor pilin ComGF	Machinery gene
H0501_RS08825 (STHERMO_1971)	comGE	1715705..1715998 (-)	294	WP_082309154.1	competence type IV pilus minor pilin ComGE	-
H0501_RS08830 (STHERMO_1972)	comGD	1715970..1716398 (-)	429	WP_253269448.1	competence type IV pilus minor pilin ComGD	-
H0501_RS08835 (STHERMO_1973)	comYC	1716358..1716684 (-)	327	WP_002946126.1	competence type IV pilus major pilin ComGC	Machinery gene
H0501_RS08840 (STHERMO_1974)	comYB	1716681..1717781 (-)	1101	WP_120764773.1	competence type IV pilus assembly protein ComGB	Machinery gene
H0501_RS08845 (STHERMO_1975)	comGA/cglA/cilD	1717663..1718604 (-)	942	WP_014608745.1	competence type IV pilus ATPase ComGA	Machinery gene
H0501_RS08850 (STHERMO_1976)	-	1718685..1719047 (-)	363	WP_014608746.1	DUF1033 family protein	-

Sequence

Protein

• Length: 108 a.a.
• Molecular weight: 11914.00 Da
• Isoelectric Point: 9.9219

>NTDB_id=1130523 H0501_RS08835 WP_002946126.1 1716358..1716684(-) (comYC) [Streptococcus thermophilus isolate STH_CIRM_18]
MKLMLKKLNAVKLRAFTLIEMLVVLLIISILLLLFVPNLSKQKDSVKETGNAAVVKVVDSQAELYEMKNNKTASLAALVS
EGQITQKQADSYNDYYAKHGGESRSVAN

Nucleotide

• Length: 327 bp

>NTDB_id=1130523 H0501_RS08835 WP_002946126.1 1716358..1716684(-) (comYC) [Streptococcus thermophilus isolate STH_CIRM_18]
ATGAAATTGATGTTAAAAAAATTGAATGCTGTTAAATTACGAGCCTTTACTCTGATTGAAATGCTAGTCGTACTTCTCAT
TATCAGTATTCTCCTTTTGCTCTTTGTTCCTAACTTAAGCAAGCAGAAGGATTCCGTTAAGGAAACTGGAAATGCGGCTG
TAGTCAAGGTCGTGGATTCTCAGGCAGAACTTTATGAAATGAAGAATAACAAGACAGCTAGCTTGGCAGCTCTTGTTTCA
GAAGGTCAAATTACGCAAAAACAGGCAGATTCATACAATGATTACTATGCGAAACATGGTGGTGAAAGCCGCTCAGTGGC
CAATTAG

Domains

Predicted by InterproScan.

• Prokaryotic N-terminal methylation motif (N_methyl) (14-34)

3D structure

• AlphaFold DB: A0A0E2Q1B3

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comYC	Streptococcus mutans UA140	69.231	96.296	0.667
comYC	Streptococcus mutans UA159	69.231	96.296	0.667
comYC	Streptococcus gordonii str. Challis substr. CH1	63.81	97.222	0.62
comGC/cglC	Streptococcus mitis SK321	62.264	98.148	0.611
comGC/cglC	Streptococcus mitis NCTC 12261	58.333	100	0.583
comGC/cglC	Streptococcus pneumoniae D39	58.491	98.148	0.574
comGC/cglC	Streptococcus pneumoniae R6	58.491	98.148	0.574
comGC/cglC	Streptococcus pneumoniae Rx1	58.491	98.148	0.574
comGC/cglC	Streptococcus pneumoniae TIGR4	58.491	98.148	0.574
comGC	Lactococcus lactis subsp. cremoris KW2	56.604	98.148	0.556
comYC	Streptococcus suis isolate S10	60.227	81.481	0.491
comGC	Staphylococcus aureus MW2	50	72.222	0.361
comGC	Staphylococcus aureus N315	50	72.222	0.361