Detailed information    

insolico Bioinformatically predicted

Overview

Name   comE/blpR   Type   Regulator
Locus tag   FGL04_RS11335 Genome accession   NZ_LR594035
Coordinates   549478..549681 (+) Length   67 a.a.
NCBI ID   WP_181950250.1    Uniprot ID   -
Organism   Streptococcus pseudoporcinus strain NCTC5385     
Function   activate transcription of early competence genes; regulation of comX expression (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Prophage 507170..559394 549478..549681 within 0
IScluster/Tn 548575..550849 549478..549681 within 0


Gene organization within MGE regions


Location: 507170..559394
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  FGL04_RS02790 (NCTC5385_00586) - 507170..507799 (-) 630 WP_077323440.1 YigZ family protein -
  FGL04_RS02795 (NCTC5385_00588) - 508007..509112 (+) 1106 WP_138068165.1 IS3 family transposase -
  FGL04_RS02800 (NCTC5385_00589) comFA/cflA 509127..510377 (+) 1251 WP_225247757.1 DEAD/DEAH box helicase Machinery gene
  FGL04_RS02805 (NCTC5385_00590) - 510367..510870 (+) 504 WP_225247758.1 ComF family protein -
  FGL04_RS10895 - 510907..511047 (+) 141 WP_225247843.1 phosphoribosyltransferase family protein -
  FGL04_RS02810 (NCTC5385_00591) - 511086..512219 (-) 1134 Protein_532 IS3 family transposase -
  FGL04_RS02815 (NCTC5385_00593) - 512299..512472 (+) 174 Protein_533 ParA family protein -
  FGL04_RS02820 (NCTC5385_00594) - 512472..512717 (+) 246 WP_138068167.1 hypothetical protein -
  FGL04_RS02825 - 512761..513144 (+) 384 Protein_535 replication initiator protein A -
  FGL04_RS02830 (NCTC5385_00596) - 513148..513507 (+) 360 WP_138068168.1 hypothetical protein -
  FGL04_RS02835 (NCTC5385_00597) - 513491..513760 (+) 270 WP_138068169.1 hypothetical protein -
  FGL04_RS02840 (NCTC5385_00598) - 513924..515219 (+) 1296 WP_225247844.1 ISLre2 family transposase -
  FGL04_RS02875 (NCTC5385_00606) - 521454..521768 (-) 315 WP_138068170.1 DUF960 domain-containing protein -
  FGL04_RS02880 (NCTC5385_00607) - 521830..522363 (-) 534 WP_138068171.1 DUF402 domain-containing protein -
  FGL04_RS02885 (NCTC5385_00608) recX 522444..523220 (-) 777 WP_171011267.1 recombination regulator RecX -
  FGL04_RS02890 - 523321..524075 (-) 755 Protein_542 IS3 family transposase -
  FGL04_RS02900 - 525294..525687 (-) 394 Protein_544 transposase -
  FGL04_RS02905 - 525767..525949 (+) 183 Protein_545 DNA topoisomerase III -
  FGL04_RS10695 (NCTC5385_00614) - 526030..526167 (+) 138 Protein_546 AAA family ATPase -
  FGL04_RS02910 (NCTC5385_00615) - 526187..527098 (-) 912 Protein_547 IS3 family transposase -
  FGL04_RS02915 (NCTC5385_00617) - 527175..528280 (+) 1106 WP_138068165.1 IS3 family transposase -
  FGL04_RS02920 (NCTC5385_00618) - 528322..528552 (-) 231 Protein_549 transposase -
  FGL04_RS02925 (NCTC5385_00619) - 528632..529189 (+) 558 Protein_550 hypothetical protein -
  FGL04_RS02930 (NCTC5385_00620) - 529242..530474 (+) 1233 WP_138068173.1 MFS transporter -
  FGL04_RS02935 (NCTC5385_00621) - 530491..531366 (+) 876 WP_138068174.1 shikimate dehydrogenase -
  FGL04_RS02940 (NCTC5385_00622) - 531913..532521 (+) 609 WP_138068175.1 VTT domain-containing protein -
  FGL04_RS02945 (NCTC5385_00623) - 532836..533099 (+) 264 WP_225247759.1 hypothetical protein -
  FGL04_RS02955 (NCTC5385_00626) - 534675..536519 (+) 1845 WP_138068176.1 glycerophosphoryl diester phosphodiesterase membrane domain-containing protein -
  FGL04_RS02960 (NCTC5385_00627) - 536850..537248 (-) 399 Protein_557 DDE-type integrase/transposase/recombinase -
  FGL04_RS02965 (NCTC5385_00629) - 537315..538420 (+) 1106 WP_138068165.1 IS3 family transposase -
  FGL04_RS10820 (NCTC5385_00630) - 538447..538826 (-) 380 Protein_559 IS3 family transposase -
  FGL04_RS02980 (NCTC5385_00633) - 540043..540302 (-) 260 Protein_561 transposase -
  FGL04_RS02995 (NCTC5385_00634) - 540861..541178 (+) 318 WP_225247845.1 tyrosine-type recombinase/integrase -
  FGL04_RS03005 (NCTC5385_00636) - 541651..543021 (-) 1371 WP_138068179.1 MATE family efflux transporter -
  FGL04_RS03010 (NCTC5385_00637) - 543033..543467 (-) 435 WP_138068180.1 MarR family winged helix-turn-helix transcriptional regulator -
  FGL04_RS03015 (NCTC5385_00638) - 543686..543940 (+) 255 WP_077322853.1 DUF1912 family protein -
  FGL04_RS03020 (NCTC5385_00640) - 544431..544976 (+) 546 Protein_566 GNAT family N-acetyltransferase -
  FGL04_RS03025 (NCTC5385_00641) - 545012..545578 (+) 567 WP_138068181.1 ATP-binding protein -
  FGL04_RS03030 (NCTC5385_00642) - 545649..548300 (+) 2652 WP_138068182.1 valine--tRNA ligase -
  FGL04_RS03035 tnpA 548575..549053 (+) 479 Protein_569 IS200/IS605 family transposase -
  FGL04_RS11335 (NCTC5385_00646) comE/blpR 549478..549681 (+) 204 WP_181950250.1 hypothetical protein Regulator
  FGL04_RS03050 (NCTC5385_00648) - 549744..550849 (+) 1106 WP_138068165.1 IS3 family transposase -
  FGL04_RS03055 - 550896..551057 (+) 162 WP_225247760.1 hypothetical protein -
  FGL04_RS11245 - 551548..551670 (+) 123 WP_269902558.1 hypothetical protein -
  FGL04_RS03070 (NCTC5385_00649) mutM 552002..552823 (+) 822 WP_138068183.1 DNA-formamidopyrimidine glycosylase -
  FGL04_RS03075 (NCTC5385_00650) coaE 552820..553425 (+) 606 WP_138068184.1 dephospho-CoA kinase -
  FGL04_RS03080 (NCTC5385_00651) - 553730..555229 (+) 1500 WP_138068185.1 helicase HerA-like domain-containing protein -
  FGL04_RS03085 (NCTC5385_00652) - 555361..556530 (+) 1170 WP_333473201.1 multidrug efflux MFS transporter -
  FGL04_RS03090 rpmG 556527..556673 (+) 147 WP_077323081.1 50S ribosomal protein L33 -
  FGL04_RS03095 (NCTC5385_00653) secG 556719..556955 (+) 237 WP_007895702.1 preprotein translocase subunit SecG -
  FGL04_RS03100 (NCTC5385_00654) rnr 557043..559394 (+) 2352 WP_138068187.1 ribonuclease R -

Sequence

Protein


Download         Length: 67 a.a.        Molecular weight: 8052.34 Da        Isoelectric Point: 9.3267

>NTDB_id=1127326 FGL04_RS11335 WP_181950250.1 549478..549681(+) (comE/blpR) [Streptococcus pseudoporcinus strain NCTC5385]
MKKKKGWEIARQIRNLDPYAVIVFVTTHSEFMPYTYKYRVSALDFIKKDVDDSTFKKLIQEVLEYSE

Nucleotide


Download         Length: 204 bp        

>NTDB_id=1127326 FGL04_RS11335 WP_181950250.1 549478..549681(+) (comE/blpR) [Streptococcus pseudoporcinus strain NCTC5385]
ATGAAAAAAAAGAAAGGTTGGGAAATTGCTAGACAGATTAGAAATTTAGATCCGTATGCAGTTATTGTATTCGTTACAAC
ACATTCAGAATTTATGCCATATACATACAAATATCGGGTATCTGCATTAGATTTTATTAAAAAAGATGTAGATGACTCTA
CATTTAAAAAGTTAATACAAGAGGTTTTAGAATATTCTGAATAG

Domains


No domain identified.



Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comE/blpR Streptococcus mutans UA159

56.923

97.015

0.552
  comE/comE2 Streptococcus equinus JB1

56.25

95.522

0.537
  comE Streptococcus pneumoniae D39

54.688

95.522

0.522
  comE Streptococcus pneumoniae R6

54.688

95.522

0.522
  comE Streptococcus pneumoniae TIGR4

54.688

95.522

0.522
  comE Streptococcus mitis SK321

54.688

95.522

0.522
  comE Streptococcus mitis NCTC 12261

54.688

95.522

0.522
  comE Streptococcus infantis strain Atu-4

54.688

95.522

0.522
  comE Streptococcus pneumoniae Rx1

54.688

95.522

0.522
  comE/comE2 Streptococcus gordonii strain NCTC7865

53.846

97.015

0.522
  comE/comE1 Streptococcus gordonii str. Challis substr. CH1

53.846

97.015

0.522
  comE/comE1 Streptococcus equinus JB1

52.459

91.045

0.478
  agrA Staphylococcus aureus N315

41.667

89.552

0.373

Multiple sequence alignment