Detailed information NTG1120922

Bioinformatically predicted

Overview

• Name: comE
• Type: Regulator
• Locus tag: EL115_RS09495
• Genome accession: NZ_LR134307
• Coordinates: 1885460..1886209 (-)
• Length: 249 a.a.
• NCBI ID: WP_126441852.1
• Uniprot ID: -
• Organism: Streptococcus milleri strain NCTC10708
• Function: activate transcription of early competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1880460..1891209

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
EL115_RS09475 (NCTC10708_01875)	-	1880863..1882485 (+)	1623	WP_126441850.1	ABC-F family ATP-binding cassette domain-containing protein	-
EL115_RS09480 (NCTC10708_01876)	-	1882559..1885135 (+)	2577	WP_126441851.1	YfhO family protein	-
EL115_RS09495 (NCTC10708_01879)	comE	1885460..1886209 (-)	750	WP_126441852.1	competence system response regulator transcription factor ComE	Regulator
EL115_RS09500 (NCTC10708_01880)	comD/comD2	1886209..1887531 (-)	1323	WP_126441853.1	GHKL domain-containing protein	Regulator
EL115_RS09505 (NCTC10708_01881)	-	1887546..1887695 (-)	150	WP_080983098.1	ComC/BlpC family leader-containing pheromone/bacteriocin	-
EL115_RS09515 (NCTC10708_01883)	rlmH	1887978..1888457 (-)	480	WP_126441854.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
EL115_RS09520 (NCTC10708_01884)	htrA	1888662..1889852 (+)	1191	WP_006270334.1	S1C family serine protease	Regulator
EL115_RS09525 (NCTC10708_01885)	spo0J	1889907..1890674 (+)	768	WP_003071657.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 249 a.a.
• Molecular weight: 29201.77 Da
• Isoelectric Point: 8.0453

>NTDB_id=1120922 EL115_RS09495 WP_126441852.1 1885460..1886209(-) (comE) [Streptococcus milleri strain NCTC10708]
MKVLILEDEITHQVRMETTLAEIAKEMGIPIKVKITGKVREFKEYIENDEVNQLYFLDIDIKGEETKGLEIAKFIRHHNP
YAIIVFVTTKSEFATMTFKYKVSALDFVDKNLNDAAFKKHIKDSIEYTKATLIENKDMVDYFEYSFRGGEVRMPFNDILY
IETTGSSHKLRIVGKNFFKEFYGTIADIQEKDEKTQRFFSPHKSYLVNIGNIKGYDKKMREIIFYEDHRCPITRMKIGKL
KSILEESKG

Nucleotide

• Length: 750 bp

>NTDB_id=1120922 EL115_RS09495 WP_126441852.1 1885460..1886209(-) (comE) [Streptococcus milleri strain NCTC10708]
ATGAAAGTACTAATATTAGAAGATGAAATTACACATCAAGTTAGAATGGAAACAACATTGGCAGAAATAGCTAAGGAAAT
GGGGATTCCGATAAAAGTTAAAATAACTGGAAAAGTAAGAGAATTTAAAGAATATATTGAAAACGATGAAGTAAATCAAT
TATATTTTTTAGATATTGATATTAAAGGTGAAGAAACAAAAGGGTTAGAAATAGCCAAATTTATACGGCATCACAATCCT
TATGCCATTATTGTTTTTGTTACAACAAAATCAGAATTTGCTACTATGACGTTTAAATATAAAGTATCTGCATTGGATTT
TGTTGATAAAAATTTGAATGATGCTGCTTTTAAAAAACATATAAAAGACAGTATTGAGTATACAAAAGCAACGTTGATTG
AAAATAAAGATATGGTTGATTATTTTGAATATAGTTTCCGTGGTGGCGAAGTTAGAATGCCTTTTAATGATATTTTATAT
ATTGAAACGACAGGTTCTTCTCATAAATTAAGAATTGTTGGTAAAAACTTTTTTAAAGAATTTTATGGTACGATTGCAGA
TATTCAGGAAAAAGACGAGAAAACACAGCGCTTCTTTTCACCTCATAAATCTTATCTAGTTAATATTGGAAATATTAAAG
GTTATGACAAAAAAATGAGAGAAATTATTTTTTATGAAGATCACCGTTGTCCGATTACTCGAATGAAAATTGGAAAGTTG
AAATCTATTTTAGAGGAGTCAAAAGGATGA

Domains

Predicted by InterproScan.

• LytTr DNA-binding domain (LytTR) (152-244)

• Response regulator receiver domain (Response_reg) (3-121)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE	Streptococcus mitis NCTC 12261	71.837	98.394	0.707
comE	Streptococcus mitis SK321	71.02	98.394	0.699
comE	Streptococcus infantis strain Atu-4	71.02	98.394	0.699
comE	Streptococcus pneumoniae TIGR4	70.612	98.394	0.695
comE	Streptococcus pneumoniae R6	70.612	98.394	0.695
comE	Streptococcus pneumoniae Rx1	70.612	98.394	0.695
comE	Streptococcus pneumoniae D39	70.612	98.394	0.695
comE/comE2	Streptococcus gordonii strain NCTC7865	69.262	97.992	0.679
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	69.262	97.992	0.679
comE/blpR	Streptococcus mutans UA159	39.759	100	0.398
comE/comE2	Streptococcus equinus JB1	35.019	100	0.361