Detailed information    

insolico Bioinformatically predicted

Overview

Name   comD/comD2   Type   Regulator
Locus tag   EL115_RS09500 Genome accession   NZ_LR134307
Coordinates   1886209..1887531 (-) Length   440 a.a.
NCBI ID   WP_126441853.1    Uniprot ID   -
Organism   Streptococcus milleri strain NCTC10708     
Function   phosphorylation of ComE (predicted from homology)   
Competence regulation

Genomic Context

Location: 1881209..1892531
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  EL115_RS09480 (NCTC10708_01876) - 1882559..1885135 (+) 2577 WP_126441851.1 YfhO family protein -
  EL115_RS09495 (NCTC10708_01879) comE 1885460..1886209 (-) 750 WP_126441852.1 competence system response regulator transcription factor ComE Regulator
  EL115_RS09500 (NCTC10708_01880) comD/comD2 1886209..1887531 (-) 1323 WP_126441853.1 GHKL domain-containing protein Regulator
  EL115_RS09505 (NCTC10708_01881) - 1887546..1887695 (-) 150 WP_080983098.1 ComC/BlpC family leader-containing pheromone/bacteriocin -
  EL115_RS09515 (NCTC10708_01883) rlmH 1887978..1888457 (-) 480 WP_126441854.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  EL115_RS09520 (NCTC10708_01884) htrA 1888662..1889852 (+) 1191 WP_006270334.1 S1C family serine protease Regulator
  EL115_RS09525 (NCTC10708_01885) spo0J 1889907..1890674 (+) 768 WP_003071657.1 ParB/RepB/Spo0J family partition protein Regulator

Sequence

Protein


Download         Length: 440 a.a.        Molecular weight: 51768.53 Da        Isoelectric Point: 7.7081

>NTDB_id=1120923 EL115_RS09500 WP_126441853.1 1886209..1887531(-) (comD/comD2) [Streptococcus milleri strain NCTC10708]
MNLDKIFIIISFIIGILSFSVVHKKISKVKIIDFRFTLLCLCLFLFSAFINSINSLLAYLCLLLEPIIIYFYFYRFKRYE
KYISVFATFLIYSSVTTSETFFSVIISSVTGDEFVDRYWGLFYIFINIISLIFILKTIDYFKFNFKYFKKVDFKDKIVQL
NFYLLFIHFLLNVSHWLSNMKSLNSFSSMIATICFLMFMSILFYLQSIREKYEKEEQIKQKEQEQLQLQKYTDEIVSLYN
EIRGFRHDYGGMLASFQSAIHTGDIKEVERIYQEVLVNANLQLRSDKYTYFDLNNVGDSALRSVMTQTLFKARDYNIELT
FEVKDFVKPLPIKLLDLVRMTSVLLNNAIEGAAESYQKTMNVSLVDLDTETILVIQNSRKKRPLDLEEIYQTDFSTKGVG
RGLGLSNIKEIINNYEGIILDTKIEDEYFIQAMRVRKEGL

Nucleotide


Download         Length: 1323 bp        

>NTDB_id=1120923 EL115_RS09500 WP_126441853.1 1886209..1887531(-) (comD/comD2) [Streptococcus milleri strain NCTC10708]
ATGAATCTGGATAAAATATTTATAATTATTTCTTTTATTATCGGAATTTTATCTTTTTCAGTTGTTCATAAAAAAATTAG
TAAAGTGAAAATTATAGATTTTCGCTTTACTTTATTGTGTTTATGTTTATTTTTATTTTCAGCCTTTATAAATTCAATAA
ATTCCTTATTAGCTTATTTATGTTTATTATTAGAGCCTATTATAATTTACTTTTATTTTTATCGTTTTAAGAGATATGAG
AAGTATATATCAGTTTTTGCAACCTTTTTAATTTATTCATCTGTAACCACTTCTGAAACCTTCTTTTCAGTCATTATTTC
TTCTGTCACAGGTGATGAGTTTGTTGATAGATACTGGGGATTGTTCTATATTTTTATCAATATTATTTCTTTAATTTTTA
TTTTAAAAACTATTGATTATTTTAAGTTTAATTTTAAATATTTTAAAAAGGTTGATTTCAAAGATAAGATTGTACAGTTA
AATTTTTATCTATTATTCATTCATTTTTTATTAAATGTATCGCATTGGCTTAGCAATATGAAAAGTTTAAATAGTTTTTC
TAGTATGATTGCGACGATTTGCTTTTTGATGTTTATGTCAATTTTATTCTACTTACAATCTATTCGCGAAAAATATGAAA
AAGAAGAACAAATTAAGCAAAAAGAACAGGAACAACTGCAATTACAAAAATATACAGATGAAATTGTGAGTCTTTACAAT
GAAATTCGAGGTTTTCGTCATGATTATGGTGGGATGTTGGCAAGTTTTCAATCAGCTATTCATACAGGTGATATAAAAGA
AGTGGAGCGAATCTATCAGGAGGTTCTGGTAAATGCTAATTTACAGCTTCGTTCTGATAAATATACGTATTTTGATTTAA
ATAATGTTGGAGATTCAGCACTTAGAAGTGTTATGACGCAAACATTATTTAAGGCACGAGATTACAATATAGAATTAACA
TTTGAAGTAAAAGATTTTGTTAAACCTTTGCCAATTAAATTGTTAGATCTAGTTAGAATGACAAGTGTTCTTTTAAATAA
TGCCATAGAAGGAGCAGCAGAAAGTTATCAAAAAACAATGAATGTTTCTTTAGTAGATCTGGATACAGAAACGATCTTAG
TTATTCAAAATTCACGTAAGAAAAGACCTCTAGATTTGGAAGAAATTTACCAAACTGATTTTTCAACAAAGGGTGTGGGA
CGCGGTTTAGGTTTAAGTAATATTAAAGAAATTATTAATAATTATGAAGGAATTATTCTGGATACTAAAATCGAAGATGA
ATATTTTATACAAGCAATGAGAGTAAGGAAAGAAGGTCTATAA

Domains

Predicted by InterproScan.

GHKL domain (HATPase_c_5)

(333-433)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comD/comD2 Streptococcus gordonii strain NCTC7865

55.056

100

0.557
  comD/comD1 Streptococcus gordonii str. Challis substr. CH1

59.635

87.273

0.52
  comD/comD1 Streptococcus pneumoniae R6

43.649

98.409

0.43
  comD/comD1 Streptococcus pneumoniae Rx1

43.649

98.409

0.43
  comD/comD1 Streptococcus pneumoniae D39

43.649

98.409

0.43
  comD Streptococcus mitis SK321

44

96.591

0.425
  comD Streptococcus mitis NCTC 12261

47.453

84.773

0.402
  comD/comD2 Streptococcus pneumoniae TIGR4

47.185

84.773

0.4

Multiple sequence alignment