Detailed information NTG1120924

Bioinformatically predicted

Overview

• Name: htrA
• Type: Regulator
• Locus tag: EL115_RS09520
• Genome accession: NZ_LR134307
• Coordinates: 1888662..1889852 (+)
• Length: 396 a.a.
• NCBI ID: WP_006270334.1
• Uniprot ID: U2XXY1
• Organism: Streptococcus milleri strain NCTC10708
• Function: repress competence development (predicted from homology) Competence regulation

Genomic Context

Location: 1883662..1894852

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
EL115_RS09495 (NCTC10708_01879)	comE	1885460..1886209 (-)	750	WP_126441852.1	competence system response regulator transcription factor ComE	Regulator
EL115_RS09500 (NCTC10708_01880)	comD/comD2	1886209..1887531 (-)	1323	WP_126441853.1	GHKL domain-containing protein	Regulator
EL115_RS09505 (NCTC10708_01881)	-	1887546..1887695 (-)	150	WP_080983098.1	ComC/BlpC family leader-containing pheromone/bacteriocin	-
EL115_RS09515 (NCTC10708_01883)	rlmH	1887978..1888457 (-)	480	WP_126441854.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
EL115_RS09520 (NCTC10708_01884)	htrA	1888662..1889852 (+)	1191	WP_006270334.1	S1C family serine protease	Regulator
EL115_RS09525 (NCTC10708_01885)	spo0J	1889907..1890674 (+)	768	WP_003071657.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 396 a.a.
• Molecular weight: 41637.72 Da
• Isoelectric Point: 9.8633

>NTDB_id=1120924 EL115_RS09520 WP_006270334.1 1888662..1889852(+) (htrA) [Streptococcus milleri strain NCTC10708]
MKNSSNFTKKLLWLFMVLAIGFIGGLFGNLTSSKLSTNSSTTTKVNKVTTAYKNTNSTTQAVSKVKDAVVSVITYANNNS
QNSVFGNDDSNTNNDNSQQVASEGSGVIYKKDGKYAYLVTNTHVINGAKKVDIRLADGNKVPGEIIGSDTYSDISVVRIS
ADKVKTVAEFGDSSKLTVGETAIAIGSPLGSNYANTVTQGIISSLNRNVSLKSESGQTISTQAIQTDTAINPGNSGGPLV
NIQGQVIGITSSKIASNGGTSVEGLGFAIPSNDVINIINQLEANGTVTRPALGIQMIDITNLSNSDLSRLKLPSKVTSGV
VVRSAQAGMPAAGKLQKYDVITKVDGKDISSVSDLQSALYKHSIGDDIKITFYRNGKETTTTIKLTKSTKDLDSNN

Nucleotide

• Length: 1191 bp

>NTDB_id=1120924 EL115_RS09520 WP_006270334.1 1888662..1889852(+) (htrA) [Streptococcus milleri strain NCTC10708]
ATGAAAAATTCTTCAAATTTTACAAAAAAATTATTATGGCTTTTCATGGTCTTAGCTATAGGTTTTATTGGTGGTTTATT
TGGAAACTTAACCTCATCAAAATTATCAACAAATAGTTCTACAACAACTAAGGTTAACAAAGTTACTACTGCTTATAAAA
ATACAAATTCTACAACACAAGCTGTAAGCAAAGTAAAGGATGCAGTTGTATCTGTTATTACCTATGCTAATAATAATTCT
CAAAATAGTGTTTTTGGAAATGATGATTCAAATACTAATAACGATAATTCTCAACAAGTGGCTAGTGAAGGATCTGGGGT
TATTTATAAAAAAGACGGAAAATACGCCTACTTAGTGACCAATACCCATGTTATTAATGGTGCTAAAAAAGTTGATATTC
GTTTGGCTGATGGGAATAAAGTTCCTGGAGAAATTATAGGTTCAGATACTTATTCTGATATCTCTGTTGTTCGTATTAGT
GCTGATAAAGTAAAAACAGTTGCTGAGTTTGGAGATTCTAGTAAATTAACTGTTGGTGAAACAGCTATTGCGATTGGAAG
TCCACTCGGATCAAATTATGCTAATACTGTGACACAAGGAATTATTTCTAGCTTAAATCGTAATGTGTCTTTAAAATCTG
AAAGCGGTCAAACTATTTCAACACAAGCTATCCAAACTGATACAGCTATCAATCCAGGGAATTCTGGTGGTCCACTTGTA
AATATCCAAGGACAAGTAATTGGTATTACTTCAAGTAAAATTGCTAGCAACGGTGGAACTTCTGTTGAGGGATTAGGTTT
TGCCATTCCATCTAATGATGTTATTAATATTATCAATCAATTAGAAGCAAACGGAACTGTTACACGACCAGCTCTAGGAA
TCCAAATGATCGACATCACTAATCTGTCTAATTCAGATTTATCACGCTTAAAACTCCCATCCAAAGTAACTAGTGGGGTT
GTTGTACGTTCAGCTCAAGCTGGGATGCCTGCAGCAGGAAAGCTTCAAAAATATGATGTTATTACAAAAGTAGATGGCAA
AGACATTTCCTCAGTAAGTGATTTACAATCTGCTTTATACAAACATTCAATTGGTGATGATATAAAAATTACATTTTATC
GTAATGGAAAAGAAACAACAACTACTATTAAGCTGACAAAATCTACAAAAGATTTAGATTCAAATAATTGA

Domains

Predicted by InterproScan.

• Trypsin-like peptidase domain (Trypsin_2) (104-249)

• PDZ domain (PDZ_2) (290-385)

• Peptidase family M50 (Peptidase_M50) (266-390)

3D structure

• AlphaFold DB: U2XXY1

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
htrA	Streptococcus gordonii str. Challis substr. CH1	74.25	100	0.75
htrA	Streptococcus mitis NCTC 12261	72.292	100	0.725
htrA	Streptococcus pneumoniae R6	72.04	100	0.722
htrA	Streptococcus pneumoniae TIGR4	72.04	100	0.722
htrA	Streptococcus pneumoniae D39	72.04	100	0.722
htrA	Streptococcus pneumoniae Rx1	72.04	100	0.722
htrA	Streptococcus mutans UA159	55.838	99.495	0.556