Detailed information    

insolico Bioinformatically predicted

Overview

Name   comYC   Type   Machinery gene
Locus tag   EW021_RS00605 Genome accession   NZ_LR130236
Coordinates   97757..98083 (+) Length   108 a.a.
NCBI ID   WP_002986552.1    Uniprot ID   -
Organism   Streptococcus pyogenes strain 5448 isolate 5448     
Function   dsDNA binding to the cell surface; assembly of the pseudopilus (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 92757..103083
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  EW021_RS00590 - 95389..95754 (+) 366 WP_002986560.1 DUF1033 family protein -
  EW021_RS00595 comYA 95847..96785 (+) 939 WP_010921798.1 competence type IV pilus ATPase ComGA Machinery gene
  EW021_RS00600 comYB 96721..97755 (+) 1035 WP_011054115.1 competence type IV pilus assembly protein ComGB Machinery gene
  EW021_RS00605 comYC 97757..98083 (+) 327 WP_002986552.1 competence type IV pilus major pilin ComGC Machinery gene
  EW021_RS00610 comGD 98058..98486 (+) 429 WP_002986548.1 competence type IV pilus minor pilin ComGD -
  EW021_RS00615 comGE 98443..98727 (+) 285 WP_002987779.1 competence type IV pilus minor pilin ComGE -
  EW021_RS00620 comYF 98720..99154 (+) 435 WP_010921800.1 competence type IV pilus minor pilin ComGF Machinery gene
  EW021_RS00625 comGG 99138..99464 (+) 327 WP_010921801.1 competence type IV pilus minor pilin ComGG -
  EW021_RS00630 comYH 99562..100515 (+) 954 WP_010921802.1 class I SAM-dependent methyltransferase Machinery gene
  EW021_RS00635 - 100574..101770 (+) 1197 WP_010921803.1 acetate kinase -
  EW021_RS00640 - 101957..102265 (+) 309 WP_010921804.1 hypothetical protein -

Sequence

Protein


Download         Length: 108 a.a.        Molecular weight: 12376.36 Da        Isoelectric Point: 9.8992

>NTDB_id=1116486 EW021_RS00605 WP_002986552.1 97757..98083(+) (comYC) [Streptococcus pyogenes strain 5448 isolate 5448]
MINQWNNLRHKKLKGFTLLEMLLVILVISVLMLLFVPNLSKQKDRVTETGNAAVVKLVENQAELYELSQGSKPSLSQLKA
DGSITEKQEKAYQDYYDKHKNEKARLSN

Nucleotide


Download         Length: 327 bp        

>NTDB_id=1116486 EW021_RS00605 WP_002986552.1 97757..98083(+) (comYC) [Streptococcus pyogenes strain 5448 isolate 5448]
ATGATTAATCAATGGAACAACTTACGACACAAGAAGCTAAAAGGATTTACTCTTCTAGAAATGTTATTGGTGATTCTTGT
CATCAGTGTTTTGATGCTATTATTTGTGCCTAATTTAAGCAAGCAAAAAGACAGGGTTACAGAAACAGGTAATGCCGCTG
TTGTTAAATTAGTGGAGAATCAAGCAGAACTATATGAATTATCTCAAGGCTCAAAACCAAGTTTGAGCCAGTTAAAGGCA
GATGGTAGTATCACTGAGAAACAAGAAAAAGCTTATCAAGACTATTATGACAAACATAAAAATGAAAAAGCCCGTCTTAG
CAATTAA

Domains

Predicted by InterproScan.

Prokaryotic N-terminal methylation motif (N_methyl)

(12-34)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comYC Streptococcus gordonii str. Challis substr. CH1

56.19

97.222

0.546
  comGC Lactococcus lactis subsp. cremoris KW2

56.863

94.444

0.537
  comGC/cglC Streptococcus mitis SK321

61.957

85.185

0.528
  comGC/cglC Streptococcus pneumoniae R6

60.87

85.185

0.519
  comGC/cglC Streptococcus pneumoniae TIGR4

60.87

85.185

0.519
  comGC/cglC Streptococcus pneumoniae D39

60.87

85.185

0.519
  comGC/cglC Streptococcus mitis NCTC 12261

60.87

85.185

0.519
  comGC/cglC Streptococcus pneumoniae Rx1

60.87

85.185

0.519
  comYC Streptococcus mutans UA140

55.208

88.889

0.491
  comYC Streptococcus mutans UA159

55.208

88.889

0.491
  comYC Streptococcus suis isolate S10

59.259

75

0.444

Multiple sequence alignment