Detailed information NTG1111424

Bioinformatically predicted

Overview

• Name: comE
• Type: Regulator
• Locus tag: ACN076_RS01310
• Genome accession: NZ_CP184836
• Coordinates: 233512..234264 (+)
• Length: 250 a.a.
• NCBI ID: WP_000866065.1
• Uniprot ID: -
• Organism: Streptococcus sp. K0074
• Function: activate transcription of early competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 228512..239264

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ACN076_RS01280 (ACN076_01280)	spo0J	229114..229872 (-)	759	WP_420789998.1	ParB/RepB/Spo0J family partition protein	Regulator
ACN076_RS01285 (ACN076_01285)	htrA	229930..231111 (-)	1182	WP_420789999.1	S1C family serine protease	Regulator
ACN076_RS01290 (ACN076_01290)	rlmH	231294..231773 (+)	480	WP_153193935.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
ACN076_RS01300 (ACN076_01300)	comC	232055..232177 (+)	123	WP_153193936.1	competence-stimulating peptide ComC	Regulator
ACN076_RS01305 (ACN076_01305)	comD/comD2	232190..233515 (+)	1326	WP_153193937.1	competence system sensor histidine kinase ComD	Regulator
ACN076_RS01310 (ACN076_01310)	comE	233512..234264 (+)	753	WP_000866065.1	competence system response regulator transcription factor ComE	Regulator
ACN076_RS01325 (ACN076_01325)	-	234507..235049 (-)	543	WP_049524461.1	TetR/AcrR family transcriptional regulator	-
ACN076_RS01330 (ACN076_01330)	-	235177..237819 (+)	2643	WP_420790000.1	YhgE/Pip family protein	-

Sequence

Protein

• Length: 250 a.a.
• Molecular weight: 29958.31 Da
• Isoelectric Point: 6.5073

>NTDB_id=1111424 ACN076_RS01310 WP_000866065.1 233512..234264(+) (comE) [Streptococcus sp. K0074]
MKVLILEDVIEHQVRLERILDEISKESNIPISYKTTGKVREFEEYIENDEVNQLYFLDIDIHGIEKKGFEVAQLIRHYNP
YAIIVFITSRSEFATLTYKYQVSALDFVDKDINDEMFKKRIEQNIFYTKSMLLENEDVVDYFDYNYKGNDLKIPYHDILY
IETTGVSHKLRIIGKNFAKEFYGTMTDIQEKDKHTQRFYSPHKSFLVNIGNIREIDRKNLEIVFYEDHRCPISRLKIRKL
KDILEKKSQK

Nucleotide

• Length: 753 bp

>NTDB_id=1111424 ACN076_RS01310 WP_000866065.1 233512..234264(+) (comE) [Streptococcus sp. K0074]
ATGAAAGTTTTAATTTTAGAGGATGTTATTGAACATCAAGTGAGACTAGAAAGAATATTGGATGAAATTTCGAAAGAATC
GAATATTCCAATATCATACAAGACAACAGGAAAAGTCCGTGAATTTGAAGAATACATTGAAAACGATGAAGTAAATCAGC
TTTATTTCCTAGATATTGATATTCATGGAATTGAGAAAAAGGGATTTGAAGTGGCTCAGCTCATTCGTCATTACAACCCT
TACGCTATTATCGTCTTTATTACCAGTCGATCAGAGTTTGCGACTCTAACCTATAAATACCAGGTATCAGCCTTAGATTT
TGTTGATAAGGATATCAATGATGAGATGTTCAAGAAGAGAATTGAGCAAAATATCTTCTACACGAAGAGTATGTTGCTTG
AAAATGAAGATGTTGTAGATTATTTTGACTACAATTACAAGGGAAATGATTTAAAAATTCCTTATCATGACATTCTGTAT
ATTGAAACGACAGGGGTCTCTCATAAATTGCGCATTATTGGTAAGAATTTTGCAAAAGAGTTCTATGGAACAATGACAGA
TATTCAGGAAAAGGACAAACATACTCAGCGATTTTATTCTCCTCATAAATCATTTTTGGTAAATATAGGCAATATTAGAG
AAATTGATCGAAAAAACTTAGAAATTGTTTTCTATGAAGACCATCGTTGTCCTATTTCAAGATTAAAAATTAGAAAATTA
AAAGATATTTTAGAGAAAAAATCTCAAAAGTGA

Domains

Predicted by InterproScan.

• LytTr DNA-binding domain (LytTR) (151-244)

• Response regulator receiver domain (Response_reg) (3-121)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE	Streptococcus pneumoniae Rx1	100	100	1
comE	Streptococcus pneumoniae D39	100	100	1
comE	Streptococcus pneumoniae R6	100	100	1
comE	Streptococcus pneumoniae TIGR4	100	100	1
comE	Streptococcus mitis SK321	99.2	100	0.992
comE	Streptococcus mitis NCTC 12261	98.4	100	0.984
comE	Streptococcus infantis strain Atu-4	91.2	100	0.912
comE/comE2	Streptococcus gordonii strain NCTC7865	62.8	100	0.628
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	62.8	100	0.628
comE/blpR	Streptococcus mutans UA159	41.296	98.8	0.408