Detailed information    

insolico Bioinformatically predicted

Overview

Name   htrA   Type   Regulator
Locus tag   ACN076_RS01285 Genome accession   NZ_CP184836
Coordinates   229930..231111 (-) Length   393 a.a.
NCBI ID   WP_420789999.1    Uniprot ID   -
Organism   Streptococcus sp. K0074     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 224930..236111
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ACN076_RS01265 (ACN076_01265) - 225986..226180 (-) 195 WP_000285186.1 DUF951 domain-containing protein -
  ACN076_RS01270 (ACN076_01270) dnaN 226245..227381 (-) 1137 WP_000581172.1 DNA polymerase III subunit beta -
  ACN076_RS01275 (ACN076_01275) dnaA 227540..228901 (-) 1362 WP_023944973.1 chromosomal replication initiator protein DnaA -
  ACN076_RS01280 (ACN076_01280) spo0J 229114..229872 (-) 759 WP_420789998.1 ParB/RepB/Spo0J family partition protein Regulator
  ACN076_RS01285 (ACN076_01285) htrA 229930..231111 (-) 1182 WP_420789999.1 S1C family serine protease Regulator
  ACN076_RS01290 (ACN076_01290) rlmH 231294..231773 (+) 480 WP_153193935.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  ACN076_RS01300 (ACN076_01300) comC 232055..232177 (+) 123 WP_153193936.1 competence-stimulating peptide ComC Regulator
  ACN076_RS01305 (ACN076_01305) comD/comD2 232190..233515 (+) 1326 WP_153193937.1 competence system sensor histidine kinase ComD Regulator
  ACN076_RS01310 (ACN076_01310) comE 233512..234264 (+) 753 WP_000866065.1 competence system response regulator transcription factor ComE Regulator
  ACN076_RS01325 (ACN076_01325) - 234507..235049 (-) 543 WP_049524461.1 TetR/AcrR family transcriptional regulator -

Sequence

Protein


Download         Length: 393 a.a.        Molecular weight: 41565.38 Da        Isoelectric Point: 6.5090

>NTDB_id=1111421 ACN076_RS01285 WP_420789999.1 229930..231111(-) (htrA) [Streptococcus sp. K0074]
MKHLKTFYKKGFQLLVVIVISFISGALGSFSIAQLTQKSSVSNSNNNSTITQTAYKNENSTTQAVNKVKDAVVSVITYSA
NRQNSVFGNDDTDTDSQQISSEGSGVIYKKNDKEAYIVTNNHVINGASKVDIRLSDGTKVPGEIVGADTFSDIAVVKISS
EKVTTVAEFGDSSKLTVGETAIAIGSPLGSEYANTVTQGIVSSLNRNVSLKSEDGQAISTKAIQTDTAINPGNSGGPLIN
IQGQVIGITSSKIATNGGTSVEGLGFAIPANDAINIIEQLEKNGKVTRPALGIQMVNLSNINTSDIRRLNIPSNVTSGVV
VRSVQSNMPANGHLEKYDVITKVDDKEISSSTDLQSALYNHSIGDTIKITYYRNGKEGTTSIKLDKSSGDLES

Nucleotide


Download         Length: 1182 bp        

>NTDB_id=1111421 ACN076_RS01285 WP_420789999.1 229930..231111(-) (htrA) [Streptococcus sp. K0074]
ATGAAACATTTAAAAACATTTTACAAAAAAGGGTTTCAATTATTAGTCGTTATCGTCATTAGCTTTATTAGTGGAGCCTT
GGGTAGTTTTTCAATAGCTCAACTAACTCAAAAAAGTAGTGTAAGCAACTCTAACAACAATAGCACCATTACACAGACTG
CCTATAAGAACGAAAATTCAACAACACAGGCTGTTAACAAAGTAAAAGATGCTGTTGTTTCAGTTATTACTTATTCAGCA
AACAGACAAAATAGCGTATTTGGAAATGATGATACTGACACAGATTCTCAACAAATCTCTAGTGAAGGATCTGGGGTTAT
TTATAAAAAGAATGATAAAGAAGCTTATATTGTCACCAATAATCACGTTATAAATGGCGCCAGCAAAGTAGATATTCGTT
TGTCAGATGGAACTAAAGTACCTGGAGAAATTGTCGGAGCTGATACTTTCTCTGATATTGCTGTCGTCAAAATATCTTCA
GAAAAAGTGACAACAGTAGCTGAGTTTGGTGATTCTAGCAAGTTAACCGTAGGAGAAACTGCCATTGCCATCGGTAGCCC
GTTAGGTTCTGAATATGCTAATACTGTCACTCAGGGTATTGTATCTAGTCTCAATCGAAATGTATCTTTAAAATCTGAAG
ATGGACAAGCCATTTCTACAAAAGCCATCCAAACTGATACTGCTATTAACCCAGGTAACTCTGGTGGCCCACTAATCAAT
ATTCAAGGACAAGTTATCGGAATTACCTCAAGTAAAATTGCCACAAATGGAGGCACATCTGTAGAAGGACTTGGTTTCGC
AATTCCCGCAAATGATGCTATCAATATTATTGAACAGTTAGAAAAGAACGGAAAAGTGACTCGTCCAGCTTTGGGAATTC
AAATGGTCAATCTCTCAAATATTAATACAAGTGATATTAGAAGACTTAATATTCCAAGCAATGTAACATCTGGTGTAGTT
GTTCGTTCTGTGCAGAGCAATATGCCTGCCAATGGTCACCTTGAAAAATACGATGTTATTACAAAAGTAGACGACAAGGA
GATTTCTTCATCAACAGACTTACAAAGTGCTCTTTACAATCATTCTATCGGAGACACTATTAAAATAACTTACTATCGTA
ACGGTAAAGAAGGAACTACATCTATTAAACTTGACAAGAGTTCAGGCGATTTAGAATCTTAA

Domains

Predicted by InterproScan.

PDZ domain (PDZ_2)

(289-384)

Trypsin-like peptidase domain (Trypsin_2)

(103-248)

Peptidase family M50 (Peptidase_M50)

(236-388)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  htrA Streptococcus mitis NCTC 12261

98.219

100

0.982
  htrA Streptococcus pneumoniae Rx1

97.201

100

0.972
  htrA Streptococcus pneumoniae D39

97.201

100

0.972
  htrA Streptococcus pneumoniae R6

97.201

100

0.972
  htrA Streptococcus pneumoniae TIGR4

97.201

100

0.972
  htrA Streptococcus gordonii str. Challis substr. CH1

66.919

100

0.674
  htrA Streptococcus mutans UA159

54.569

100

0.547

Multiple sequence alignment