Detailed information    

insolico Bioinformatically predicted

Overview

Name   comD/comD2   Type   Regulator
Locus tag   ACN076_RS01305 Genome accession   NZ_CP184836
Coordinates   232190..233515 (+) Length   441 a.a.
NCBI ID   WP_153193937.1    Uniprot ID   A0A6L5H5Y2
Organism   Streptococcus sp. K0074     
Function   phosphorylation of ComE (predicted from homology)   
Competence regulation

Genomic Context

Location: 227190..238515
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ACN076_RS01275 (ACN076_01275) dnaA 227540..228901 (-) 1362 WP_023944973.1 chromosomal replication initiator protein DnaA -
  ACN076_RS01280 (ACN076_01280) spo0J 229114..229872 (-) 759 WP_420789998.1 ParB/RepB/Spo0J family partition protein Regulator
  ACN076_RS01285 (ACN076_01285) htrA 229930..231111 (-) 1182 WP_420789999.1 S1C family serine protease Regulator
  ACN076_RS01290 (ACN076_01290) rlmH 231294..231773 (+) 480 WP_153193935.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  ACN076_RS01300 (ACN076_01300) comC 232055..232177 (+) 123 WP_153193936.1 competence-stimulating peptide ComC Regulator
  ACN076_RS01305 (ACN076_01305) comD/comD2 232190..233515 (+) 1326 WP_153193937.1 competence system sensor histidine kinase ComD Regulator
  ACN076_RS01310 (ACN076_01310) comE 233512..234264 (+) 753 WP_000866065.1 competence system response regulator transcription factor ComE Regulator
  ACN076_RS01325 (ACN076_01325) - 234507..235049 (-) 543 WP_049524461.1 TetR/AcrR family transcriptional regulator -
  ACN076_RS01330 (ACN076_01330) - 235177..237819 (+) 2643 WP_420790000.1 YhgE/Pip family protein -

Sequence

Protein


Download         Length: 441 a.a.        Molecular weight: 51409.98 Da        Isoelectric Point: 6.8352

>NTDB_id=1111423 ACN076_RS01305 WP_153193937.1 232190..233515(+) (comD/comD2) [Streptococcus sp. K0074]
MNFFLVVDFILYFFIISHSYRLICKGQIKAKELYFFGIYTLLVEAVLELPFYLLYLDGLGIARFLFPLGLYFYFRWIKQY
ERDRGLFLSLLLSLLYESTHNFLSVTFSSLTGDNFVLQYHDPFFFVVTVLTYVVILKIIRYFHLELAYFDKDYLYPFLKK
VFFALLLLHTASFVSDMVSTIKHLNSFGSILSSIVFISLLLTFFAMNSHKEQIEKEIALKQKKFEQKHLQNYTDEIVGLY
NEIRGFRHDYAGMLVSMQMAIDSGDLQEIDRVYNEVLVKANHKLRSDKYTYFDLNNIEDSALRSLIAQSIVYARNNGVEF
TLEVKDTITKLPIELLDLVRIMSVLLNNAVEGSADSYKKQMEVAVIKMETETVIVIQNSCKMTMTPSGDLFALGFSTKGR
NRGVGLNNVKELLDKYNNIILETEMEGSTFRQIIRFKREFE

Nucleotide


Download         Length: 1326 bp        

>NTDB_id=1111423 ACN076_RS01305 WP_153193937.1 232190..233515(+) (comD/comD2) [Streptococcus sp. K0074]
ATGAATTTTTTCTTAGTAGTAGATTTTATATTATATTTTTTTATTATTAGTCATAGTTACCGTTTAATTTGTAAAGGCCA
AATAAAAGCAAAGGAACTATATTTTTTTGGTATCTATACATTACTAGTAGAAGCAGTACTTGAACTTCCTTTTTACCTCC
TATATTTAGATGGGTTAGGGATTGCAAGATTTTTATTTCCTTTGGGATTATATTTCTATTTTCGATGGATTAAACAGTAT
GAGAGGGATAGAGGACTATTCTTAAGTTTACTACTATCTCTTTTATATGAGAGCACTCATAACTTTCTGTCTGTAACTTT
CTCCTCTCTAACAGGAGACAATTTTGTTTTACAATATCATGATCCATTCTTTTTCGTTGTAACGGTATTGACTTATGTTG
TTATCTTAAAAATCATTCGTTATTTCCATTTGGAACTAGCCTATTTTGACAAAGATTACCTCTACCCTTTCTTGAAAAAA
GTATTTTTTGCTTTACTATTGCTCCATACTGCATCTTTCGTTTCAGATATGGTAAGTACGATTAAACATTTGAATAGTTT
TGGAAGTATTTTATCATCTATTGTCTTTATATCGTTACTTTTGACCTTCTTTGCAATGAATTCGCATAAAGAACAAATAG
AAAAAGAGATTGCTTTGAAGCAGAAGAAATTTGAACAGAAACATTTACAGAATTATACAGATGAAATTGTTGGCTTGTAT
AATGAAATCCGTGGGTTTCGACATGACTATGCTGGAATGCTTGTCAGTATGCAGATGGCAATTGACAGTGGTGATTTACA
GGAAATTGACAGAGTTTACAATGAAGTTTTGGTTAAAGCTAATCACAAACTGCGTTCAGATAAGTACACTTACTTTGATT
TGAACAACATAGAAGATTCAGCTTTACGAAGTTTGATTGCTCAGTCAATTGTCTATGCTCGAAATAATGGTGTAGAGTTT
ACACTGGAAGTAAAAGATACGATTACCAAGCTCCCAATTGAACTATTGGATTTGGTTCGTATCATGAGCGTTTTATTGAA
CAATGCTGTCGAAGGATCGGCTGATAGCTATAAAAAGCAGATGGAAGTAGCAGTTATTAAGATGGAAACTGAAACAGTTA
TTGTGATTCAGAATTCATGTAAAATGACGATGACTCCTTCAGGAGATCTATTTGCTTTAGGATTCTCCACTAAGGGAAGA
AATCGCGGAGTCGGATTAAATAATGTGAAAGAACTACTAGATAAGTACAACAACATCATTTTAGAAACAGAGATGGAAGG
CAGTACATTTAGACAAATTATTAGATTTAAGAGGGAATTTGAATGA

Domains

Predicted by InterproScan.

GHKL domain (HATPase_c_5)

(334-434)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A6L5H5Y2

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comD/comD2 Streptococcus pneumoniae TIGR4

93.056

97.959

0.912
  comD/comD1 Streptococcus pneumoniae Rx1

90.93

100

0.909
  comD/comD1 Streptococcus pneumoniae D39

90.93

100

0.909
  comD/comD1 Streptococcus pneumoniae R6

90.93

100

0.909
  comD Streptococcus mitis SK321

90.703

100

0.907
  comD Streptococcus mitis NCTC 12261

87.755

100

0.878
  comD/comD1 Streptococcus gordonii str. Challis substr. CH1

49.468

85.261

0.422
  comD/comD2 Streptococcus gordonii strain NCTC7865

49.202

85.261

0.42

Multiple sequence alignment