Detailed information    

insolico Bioinformatically predicted

Overview

Name   comE/blpR   Type   Regulator
Locus tag   V3C22_RS08580 Genome accession   NZ_CP183775
Coordinates   1748197..1748949 (-) Length   250 a.a.
NCBI ID   WP_002265454.1    Uniprot ID   -
Organism   Streptococcus mutans strain Xc     
Function   activate transcription of early competence genes; regulation of comX expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 1743197..1753949
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  V3C22_RS08545 (V3C22_08545) - 1743246..1743380 (-) 135 WP_080062158.1 hypothetical protein -
  V3C22_RS08550 (V3C22_08550) - 1743838..1743999 (-) 162 WP_002295609.1 hypothetical protein -
  V3C22_RS08555 (V3C22_08555) - 1744244..1745272 (-) 1029 WP_002295608.1 thioredoxin family protein -
  V3C22_RS08560 (V3C22_08560) - 1745756..1745944 (-) 189 WP_002284747.1 Blp family class II bacteriocin -
  V3C22_RS08565 (V3C22_08565) - 1746108..1746321 (-) 214 Protein_1639 Blp family class II bacteriocin -
  V3C22_RS08570 (V3C22_08570) comC/blpC 1746588..1746728 (+) 141 WP_002270250.1 ComC/BlpC family leader-containing pheromone/bacteriocin Regulator
  V3C22_RS08575 (V3C22_08575) comD/blpH 1746881..1748200 (-) 1320 WP_226706881.1 GHKL domain-containing protein Regulator
  V3C22_RS08580 (V3C22_08580) comE/blpR 1748197..1748949 (-) 753 WP_002265454.1 response regulator transcription factor Regulator
  V3C22_RS08585 (V3C22_08585) - 1749414..1750052 (-) 639 WP_002267938.1 VTT domain-containing protein -
  V3C22_RS08590 (V3C22_08590) - 1750100..1750726 (-) 627 WP_002268642.1 hypothetical protein -
  V3C22_RS08595 (V3C22_08595) der 1750801..1752111 (-) 1311 WP_002262117.1 ribosome biogenesis GTPase Der -
  V3C22_RS08600 (V3C22_08600) dnaI 1752124..1753023 (-) 900 WP_002284744.1 primosomal protein DnaI -

Sequence

Protein


Download         Length: 250 a.a.        Molecular weight: 29391.73 Da        Isoelectric Point: 8.2551

>NTDB_id=1105966 V3C22_RS08580 WP_002265454.1 1748197..1748949(-) (comE/blpR) [Streptococcus mutans strain Xc]
MISIFVLEDDFLQQGRLETTIAAIMKEKNWSYKELTIFGKPQQLIDTIPEKGSHQIFFLDIEIKKEEKKGLEVANQIRQH
NPSAVIVFVTTHSEFMPLTFQYQVSALDFIDKSLNPEEFSHRIESALYYAMENSQKNGQSEELFIFHSSETQFQVPFAEI
LYFETSSTAHKLCLYTYDERIEFYGSMTDIVKMDKRLFQCHRSFIVNPTNITRIDRKKRLAYFRNNKSCLISRTKLTKLR
AVIADQRRAK

Nucleotide


Download         Length: 753 bp        

>NTDB_id=1105966 V3C22_RS08580 WP_002265454.1 1748197..1748949(-) (comE/blpR) [Streptococcus mutans strain Xc]
ATGATTTCTATTTTTGTATTGGAAGATGATTTTTTACAACAAGGACGTCTTGAAACCACCATTGCAGCTATCATGAAAGA
AAAGAACTGGTCTTATAAAGAATTGACTATTTTTGGGAAACCACAACAACTTATTGATACTATCCCTGAAAAGGGCAGTC
ACCAGATTTTCTTTTTGGATATTGAAATCAAAAAAGAGGAAAAGAAAGGATTGGAAGTAGCCAATCAGATTAGACAGCAT
AATCCTAGTGCGGTTATTGTCTTTGTCACGACACATTCTGAGTTTATGCCCCTCACTTTTCAGTATCAGGTATCTGCTTT
GGATTTTATTGATAAATCTTTGAATCCTGAGGAGTTCTCCCACCGCATTGAATCAGCGCTGTATTATGCTATGGAAAACA
GCCAGAAGAATGGTCAATCAGAGGAACTTTTTATTTTCCATTCATCTGAAACTCAGTTTCAGGTCCCTTTTGCTGAGATT
CTGTATTTTGAAACATCTTCAACAGCCCATAAGCTCTGCCTTTATACTTATGATGAACGGATTGAATTTTATGGTAGTAT
GACTGACATTGTTAAAATGGATAAGAGACTTTTTCAGTGCCATCGCTCTTTTATTGTCAATCCTACCAATATTACCCGTA
TTGATCGGAAAAAGCGATTGGCTTATTTTCGAAATAATAAGTCTTGTCTTATTTCACGAACTAAGTTAACAAAACTGAGA
GCTGTGATTGCTGATCAAAGGAGAGCAAAATGA

Domains

Predicted by InterproScan.

LytTr DNA-binding domain (LytTR)

(153-242)

Response regulator receiver domain (Response_reg)

(4-123)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comE/blpR Streptococcus mutans UA159

98.8

100

0.988
  comE/comE1 Streptococcus equinus JB1

46.473

96.4

0.448
  comE Streptococcus mitis NCTC 12261

41.7

98.8

0.412
  comE Streptococcus infantis strain Atu-4

41.7

98.8

0.412
  comE Streptococcus pneumoniae Rx1

41.296

98.8

0.408
  comE Streptococcus mitis SK321

41.296

98.8

0.408
  comE Streptococcus pneumoniae D39

41.296

98.8

0.408
  comE Streptococcus pneumoniae R6

41.296

98.8

0.408
  comE Streptococcus pneumoniae TIGR4

41.296

98.8

0.408
  comE/comE2 Streptococcus equinus JB1

40.664

96.4

0.392
  comE/comE1 Streptococcus gordonii str. Challis substr. CH1

37.551

98

0.368
  comE/comE2 Streptococcus gordonii strain NCTC7865

37.551

98

0.368

Multiple sequence alignment