Detailed information NTG0102199

Bioinformatically predicted

Overview

• Name: comE/blpR
• Type: Regulator
• Locus tag: SMUFR_RS08805
• Genome accession: NZ_CP007016
• Coordinates: 1795320..1796072 (-)
• Length: 250 a.a.
• NCBI ID: WP_002262114.1
• Uniprot ID: Q8DS93
• Organism: Streptococcus mutans UA159-FR
• Function: activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 1790320..1801072

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SMUFR_RS08775 (SMUFR_1654)	-	1790336..1790740 (-)	405	WP_002263912.1	hypothetical protein	-
SMUFR_RS08780 (SMUFR_1655)	-	1790887..1791306 (-)	420	WP_002263913.1	hypothetical protein	-
SMUFR_RS08785 (SMUFR_1657)	-	1792687..1793088 (-)	402	WP_002310604.1	hypothetical protein	-
SMUFR_RS08790 (SMUFR_1658)	cipB	1793219..1793449 (-)	231	WP_002265368.1	Blp family class II bacteriocin	Regulator
SMUFR_RS08795	comC/blpC	1793716..1793856 (+)	141	WP_002267610.1	ComC/BlpC family leader-containing pheromone/bacteriocin	Regulator
SMUFR_RS08800 (SMUFR_1659)	comD/blpH	1793998..1795323 (-)	1326	WP_002262113.1	sensor histidine kinase	Regulator
SMUFR_RS08805 (SMUFR_1660)	comE/blpR	1795320..1796072 (-)	753	WP_002262114.1	response regulator transcription factor	Regulator
SMUFR_RS08810 (SMUFR_1661)	-	1796544..1797182 (-)	639	WP_002262115.1	VTT domain-containing protein	-
SMUFR_RS08815 (SMUFR_1662)	-	1797229..1797855 (-)	627	WP_002262116.1	hypothetical protein	-
SMUFR_RS08820 (SMUFR_1663)	der	1797930..1799240 (-)	1311	WP_002262117.1	ribosome biogenesis GTPase Der	-
SMUFR_RS08825 (SMUFR_1664)	dnaI	1799253..1800152 (-)	900	WP_002262118.1	primosomal protein DnaI	-

Sequence

Protein

• Length: 250 a.a.
• Molecular weight: 29358.71 Da
• Isoelectric Point: 8.2551

>NTDB_id=102199 SMUFR_RS08805 WP_002262114.1 1795320..1796072(-) (comE/blpR) [Streptococcus mutans UA159-FR]
MISIFVLEDDFLQQGRLETTIAAIMKEKNWSYKELTIFGKPQQLIDAIPEKGNHQIFFLDIEIKKEEKKGLEVANQIRQH
NPSAVIVFVTTHSEFMPLTFQYQVSALDFIDKSLNPEEFSHRIESALYYAMENSQKNGQSEELFIFHSSETQFQVPFAEI
LYFETSSTAHKLCLYTYDERIEFYGSMTDIVKMDKRLFQCHRSFIVNPANITRIDRKKRLAYFRNNKSCLISRTKLTKLR
AVIADQRRAK

Nucleotide

• Length: 753 bp

>NTDB_id=102199 SMUFR_RS08805 WP_002262114.1 1795320..1796072(-) (comE/blpR) [Streptococcus mutans UA159-FR]
ATGATTTCTATTTTTGTATTGGAAGATGATTTTTTACAACAAGGACGTCTTGAAACCACCATTGCAGCTATCATGAAAGA
AAAAAATTGGTCTTATAAAGAATTGACTATTTTTGGAAAACCACAACAACTTATTGACGCTATCCCTGAAAAGGGCAATC
ACCAGATTTTCTTTTTGGATATTGAAATCAAAAAAGAGGAAAAGAAAGGACTGGAAGTAGCCAATCAGATTAGACAGCAT
AATCCTAGTGCAGTTATTGTCTTTGTCACGACACATTCTGAGTTTATGCCCCTCACTTTTCAGTATCAGGTATCTGCTTT
GGATTTTATTGATAAATCTTTGAATCCTGAGGAGTTCTCCCACCGCATTGAATCAGCGCTGTATTATGCTATGGAAAACA
GCCAGAAGAATGGTCAATCAGAGGAACTTTTTATTTTCCATTCATCTGAAACTCAGTTTCAGGTCCCTTTTGCTGAGATT
CTGTATTTTGAAACATCTTCAACAGCCCATAAGCTCTGCCTTTATACTTATGATGAACGGATTGAATTCTACGGCAGTAT
GACTGACATTGTTAAAATGGATAAGAGACTTTTTCAGTGCCATCGCTCTTTTATTGTCAATCCTGCCAATATTACCCGTA
TTGATCGGAAAAAACGCTTGGCCTATTTTCGAAATAATAAGTCTTGTCTTATTTCACGAACTAAGTTAACAAAACTGAGA
GCTGTGATTGCTGATCAAAGGAGAGCAAAATGA

Domains

Predicted by InterProScan.

• Response regulator receiver domain (Response_reg) (4-123)

• LytTr DNA-binding domain (LytTR) (153-242)

3D structure

• AlphaFold DB: Q8DS93

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/blpR	Streptococcus mutans UA159	100	100	1
comE/comE1	Streptococcus equinus JB1	46.888	96.4	0.452
comE	Streptococcus mitis NCTC 12261	41.7	98.8	0.412
comE	Streptococcus infantis strain Atu-4	41.7	98.8	0.412
comE	Streptococcus pneumoniae D39	41.296	98.8	0.408
comE	Streptococcus pneumoniae Rx1	41.296	98.8	0.408
comE	Streptococcus pneumoniae R6	41.296	98.8	0.408
comE	Streptococcus pneumoniae TIGR4	41.296	98.8	0.408
comE	Streptococcus mitis SK321	41.296	98.8	0.408
comE/comE2	Streptococcus equinus JB1	40.664	96.4	0.392
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	37.551	98	0.368
comE/comE2	Streptococcus gordonii strain NCTC7865	37.551	98	0.368