Detailed information    

insolico Bioinformatically predicted

Overview

Name   comE   Type   Regulator
Locus tag   ABKJ27_RS00075 Genome accession   NZ_CP157578
Coordinates   7340..8092 (+) Length   250 a.a.
NCBI ID   WP_410011777.1    Uniprot ID   -
Organism   Streptococcus sp. KHUD_011     
Function   activate transcription of early competence genes (predicted from homology)   
Competence regulation

Genomic Context

Location: 2340..13092
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ABKJ27_RS00045 (ABKJ27_00050) spo0J 2939..3697 (-) 759 WP_410011773.1 ParB/RepB/Spo0J family partition protein Regulator
  ABKJ27_RS00050 (ABKJ27_00055) htrA 3755..4936 (-) 1182 WP_410011774.1 S1C family serine protease Regulator
  ABKJ27_RS00055 (ABKJ27_00060) rlmH 5120..5599 (+) 480 WP_410011775.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  ABKJ27_RS00065 (ABKJ27_00070) comC/comC2 5883..6005 (+) 123 WP_045612506.1 competence-stimulating peptide ComC Regulator
  ABKJ27_RS00070 (ABKJ27_00075) comD/comD1 6018..7343 (+) 1326 WP_410011776.1 competence system sensor histidine kinase ComD Regulator
  ABKJ27_RS00075 (ABKJ27_00080) comE 7340..8092 (+) 753 WP_410011777.1 competence system response regulator transcription factor ComE Regulator
  ABKJ27_RS00090 (ABKJ27_00095) - 8334..8876 (-) 543 WP_001158275.1 TetR/AcrR family transcriptional regulator -
  ABKJ27_RS00095 (ABKJ27_00100) - 9004..11646 (+) 2643 WP_410011778.1 YhgE/Pip family protein -

Sequence

Protein


Download         Length: 250 a.a.        Molecular weight: 29940.23 Da        Isoelectric Point: 6.3126

>NTDB_id=1007425 ABKJ27_RS00075 WP_410011777.1 7340..8092(+) (comE) [Streptococcus sp. KHUD_011]
MKVLILEDVIEHQVRLERILDEISKESNIPISYKTTGKVREFEEYIENDEVNQLYFLDIDIHGIEKKGFEVAQLIRHYNP
YAIIVFITSRSEFATLTYKYQVSALDFVDKDINDELFKKRIEQNIFYTKSMLLENEDVVDYFDYNYKGNDLKIPYHDILY
IETTGVSHKLRIIGKNFAKEFYGTMTDIQEQDKHTQRFYSPHKSFLVNIGNIREIDRKNLEIVFYEDHRCPISRLKIRKL
KDILEKKSQK

Nucleotide


Download         Length: 753 bp        

>NTDB_id=1007425 ABKJ27_RS00075 WP_410011777.1 7340..8092(+) (comE) [Streptococcus sp. KHUD_011]
ATGAAAGTTTTAATTTTAGAAGATGTTATTGAACATCAAGTGAGACTAGAGAGAATATTGGATGAAATTTCGAAAGAATC
GAATATTCCAATATCATACAAGACAACGGGAAAAGTCCGTGAATTTGAAGAATACATTGAAAATGATGAAGTAAATCAGC
TTTATTTCCTAGATATCGATATTCATGGAATTGAGAAAAAGGGATTTGAAGTGGCTCAGCTCATTCGTCATTACAATCCT
TACGCTATTATCGTCTTTATTACCAGTCGATCAGAGTTTGCAACTCTAACCTATAAATACCAGGTATCAGCCTTAGATTT
TGTTGATAAGGATATCAATGATGAGTTATTTAAGAAGAGAATTGAGCAAAATATCTTTTACACGAAGAGTATGTTACTTG
AAAATGAAGATGTAGTAGACTATTTTGATTACAACTATAAGGGAAATGATTTAAAAATCCCTTACCATGATATTTTGTAT
ATTGAAACGACAGGAGTCTCTCATAAATTGCGCATTATTGGTAAGAATTTTGCAAAAGAGTTTTATGGTACCATGACAGA
TATTCAGGAACAGGACAAACATACTCAGCGATTTTATTCTCCTCATAAGTCATTTTTGGTAAATATAGGCAATATCAGAG
AAATTGATCGAAAAAATCTAGAAATTGTTTTCTATGAAGACCATCGTTGTCCTATTTCAAGATTAAAAATTAGAAAATTA
AAAGATATTCTAGAGAAAAAATCTCAAAAGTAA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(3-121)

LytTr DNA-binding domain (LytTR)

(151-244)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comE Streptococcus pneumoniae Rx1

99.2

100

0.992
  comE Streptococcus pneumoniae D39

99.2

100

0.992
  comE Streptococcus pneumoniae R6

99.2

100

0.992
  comE Streptococcus pneumoniae TIGR4

99.2

100

0.992
  comE Streptococcus mitis SK321

99.2

100

0.992
  comE Streptococcus mitis NCTC 12261

98.4

100

0.984
  comE Streptococcus infantis strain Atu-4

91.2

100

0.912
  comE/comE2 Streptococcus gordonii strain NCTC7865

63.2

100

0.632
  comE/comE1 Streptococcus gordonii str. Challis substr. CH1

63.2

100

0.632
  comE/blpR Streptococcus mutans UA159

41.296

98.8

0.408

Multiple sequence alignment