Detailed information    

insolico Bioinformatically predicted

Overview

Name   htrA   Type   Regulator
Locus tag   ABKJ27_RS00050 Genome accession   NZ_CP157578
Coordinates   3755..4936 (-) Length   393 a.a.
NCBI ID   WP_410011774.1    Uniprot ID   -
Organism   Streptococcus sp. KHUD_011     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 1..9936
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ABKJ27_RS00035 (ABKJ27_00040) dnaN 70..1206 (-) 1137 WP_084950574.1 DNA polymerase III subunit beta -
  ABKJ27_RS00040 (ABKJ27_00045) dnaA 1365..2726 (-) 1362 WP_084950575.1 chromosomal replication initiator protein DnaA -
  ABKJ27_RS00045 (ABKJ27_00050) spo0J 2939..3697 (-) 759 WP_410011773.1 ParB/RepB/Spo0J family partition protein Regulator
  ABKJ27_RS00050 (ABKJ27_00055) htrA 3755..4936 (-) 1182 WP_410011774.1 S1C family serine protease Regulator
  ABKJ27_RS00055 (ABKJ27_00060) rlmH 5120..5599 (+) 480 WP_410011775.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  ABKJ27_RS00065 (ABKJ27_00070) comC/comC2 5883..6005 (+) 123 WP_045612506.1 competence-stimulating peptide ComC Regulator
  ABKJ27_RS00070 (ABKJ27_00075) comD/comD1 6018..7343 (+) 1326 WP_410011776.1 competence system sensor histidine kinase ComD Regulator
  ABKJ27_RS00075 (ABKJ27_00080) comE 7340..8092 (+) 753 WP_410011777.1 competence system response regulator transcription factor ComE Regulator
  ABKJ27_RS00090 (ABKJ27_00095) - 8334..8876 (-) 543 WP_001158275.1 TetR/AcrR family transcriptional regulator -

Sequence

Protein


Download         Length: 393 a.a.        Molecular weight: 41780.63 Da        Isoelectric Point: 6.1475

>NTDB_id=1007422 ABKJ27_RS00050 WP_410011774.1 3755..4936(-) (htrA) [Streptococcus sp. KHUD_011]
MKHLKTFYKKWFQLLVVIVISFISGALGSFSINQLTQKSTVSTSNNNSTITQTAYKNENSTTQAVNKVKDAVVSVITYSA
NRQNSVFGNDDTDTDSQQISSEGSGVIYKKNDKEAYIVTNNHVINGASKVDIRLSDGTKVPGEIVGADTFSDIAVVKISS
EKVTTVAEFGDSSKLTVGETAIAIGSPLGSEYANTVTQGIVSSLNRNVSLKSEDGQAISTKAIQTDTAINPGNSGGPLIN
IQGQVIGITSSKIATNGGTSVEGLGFAIPANDAINIIEQLEKNGKVTRPALGIQMVNLSNINTSDIRRLNIPSNVTSGVV
VRSVQSNMPANGHLEKYDVITKVDDKDIASSTDLQSALYNHSIGDTIKITYYRNGKEETTSIKLDKSSGDLES

Nucleotide


Download         Length: 1182 bp        

>NTDB_id=1007422 ABKJ27_RS00050 WP_410011774.1 3755..4936(-) (htrA) [Streptococcus sp. KHUD_011]
ATGAAACATCTAAAGACATTTTACAAAAAATGGTTTCAATTATTAGTCGTTATCGTCATTAGCTTTATTAGTGGAGCCTT
GGGTAGTTTTTCAATAAACCAACTAACTCAAAAAAGTACTGTAAGTACCTCTAACAACAATAGTACTATTACACAGACTG
CCTATAAGAATGAAAATTCAACAACACAGGCTGTTAACAAAGTAAAAGATGCTGTTGTTTCAGTTATTACTTATTCGGCA
AACAGACAAAATAGCGTATTTGGCAATGATGATACTGACACAGATTCTCAACAAATCTCTAGTGAAGGATCTGGGGTTAT
TTATAAAAAGAATGACAAAGAAGCTTATATTGTCACAAATAATCACGTTATAAATGGTGCAAGTAAAGTAGATATTCGTT
TGTCAGATGGAACTAAAGTACCCGGAGAAATTGTCGGAGCGGACACTTTCTCTGATATTGCTGTCGTCAAAATCTCTTCA
GAAAAAGTGACAACAGTAGCTGAATTTGGTGATTCTAGTAAGTTAACCGTAGGAGAAACTGCTATTGCTATTGGTAGCCC
GTTAGGTTCTGAATATGCTAATACTGTCACTCAAGGTATCGTATCTAGTCTTAATCGAAATGTATCCTTAAAATCTGAAG
ATGGACAAGCCATTTCTACAAAAGCCATCCAAACTGATACTGCTATTAACCCAGGTAACTCTGGTGGCCCACTAATCAAT
ATTCAAGGACAGGTTATCGGAATTACCTCAAGTAAAATTGCCACAAACGGAGGAACATCTGTAGAAGGCCTTGGTTTCGC
AATTCCTGCAAATGATGCTATCAATATTATTGAACAGTTGGAAAAGAACGGAAAAGTGACTCGTCCAGCTTTGGGAATTC
AAATGGTCAATCTCTCAAATATTAATACAAGTGATATTAGAAGACTGAATATTCCAAGCAATGTAACATCTGGTGTAGTT
GTTCGTTCTGTGCAAAGTAATATGCCTGCCAATGGTCACCTTGAAAAATACGATGTTATTACAAAAGTAGATGACAAAGA
CATTGCTTCATCAACAGACTTACAAAGTGCTCTTTACAATCATTCTATCGGAGATACCATTAAAATAACTTACTATCGTA
ACGGTAAAGAAGAAACTACATCTATTAAACTCGACAAGAGTTCAGGTGATTTAGAATCTTAA

Domains

Predicted by InterproScan.

Trypsin-like peptidase domain (Trypsin_2)

(103-248)

PDZ domain (PDZ_2)

(289-384)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  htrA Streptococcus mitis NCTC 12261

98.982

100

0.99
  htrA Streptococcus pneumoniae Rx1

97.201

100

0.972
  htrA Streptococcus pneumoniae D39

97.201

100

0.972
  htrA Streptococcus pneumoniae R6

97.201

100

0.972
  htrA Streptococcus pneumoniae TIGR4

97.201

100

0.972
  htrA Streptococcus gordonii str. Challis substr. CH1

66.499

100

0.672
  htrA Streptococcus mutans UA159

54.822

100

0.55

Multiple sequence alignment