Detailed information NTG0997525

Bioinformatically predicted

Overview

• Name: comE
• Type: Regulator
• Locus tag: ABC812_RS10760
• Genome accession: NZ_CP155537
• Coordinates: 2087832..2088584 (-)
• Length: 250 a.a.
• NCBI ID: WP_000866065.1
• Uniprot ID: -
• Organism: Streptococcus pneumoniae strain DP1322
• Function: activate transcription of early competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2082832..2093584

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ABC812_RS10740 (ABC812_10735)	-	2085265..2086868 (-)	1604	Protein_2077	YhgE/Pip domain-containing protein	-
ABC812_RS10745 (ABC812_10740)	-	2087047..2087589 (+)	543	WP_001158266.1	TetR/AcrR family transcriptional regulator	-
ABC812_RS10760 (ABC812_10755)	comE	2087832..2088584 (-)	753	WP_000866065.1	competence system response regulator transcription factor ComE	Regulator
ABC812_RS10765 (ABC812_10760)	comD/comD1	2088581..2089906 (-)	1326	WP_000362880.1	competence system sensor histidine kinase ComD	Regulator
ABC812_RS10770 (ABC812_10765)	comC/comC1	2089927..2090052 (-)	126	WP_000799689.1	competence-stimulating peptide ComC	Regulator
ABC812_RS10780 (ABC812_10775)	rlmH	2090334..2090813 (-)	480	WP_000695929.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
ABC812_RS10785 (ABC812_10780)	htrA	2090996..2092177 (+)	1182	WP_000681597.1	trypsin-like peptidase domain-containing protein	Regulator
ABC812_RS10790 (ABC812_10785)	spo0J	2092235..2092993 (+)	759	WP_000410378.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 250 a.a.
• Molecular weight: 29958.31 Da
• Isoelectric Point: 6.5073

>NTDB_id=997525 ABC812_RS10760 WP_000866065.1 2087832..2088584(-) (comE) [Streptococcus pneumoniae strain DP1322]
MKVLILEDVIEHQVRLERILDEISKESNIPISYKTTGKVREFEEYIENDEVNQLYFLDIDIHGIEKKGFEVAQLIRHYNP
YAIIVFITSRSEFATLTYKYQVSALDFVDKDINDEMFKKRIEQNIFYTKSMLLENEDVVDYFDYNYKGNDLKIPYHDILY
IETTGVSHKLRIIGKNFAKEFYGTMTDIQEKDKHTQRFYSPHKSFLVNIGNIREIDRKNLEIVFYEDHRCPISRLKIRKL
KDILEKKSQK

Nucleotide

• Length: 753 bp

>NTDB_id=997525 ABC812_RS10760 WP_000866065.1 2087832..2088584(-) (comE) [Streptococcus pneumoniae strain DP1322]
ATGAAAGTTTTAATTTTAGAAGATGTTATTGAACATCAAGTGAGACTAGAGAGAATATTGGATGAAATTTCGAAAGAATC
GAATATTCCAATATCATACAAGACAACGGGAAAAGTCCGTGAATTTGAAGAATACATTGAAAATGATGAAGTAAATCAGC
TTTATTTCCTAGATATCGATATTCATGGAATTGAGAAAAAGGGATTTGAAGTGGCTCAGCTCATTCGTCATTACAATCCT
TACGCTATTATCGTCTTTATCACTAGTCGATCAGAGTTTGCGACTCTAACATATAAATACCAGGTATCAGCCCTAGATTT
TGTTGATAAGGATATCAATGATGAGATGTTTAAGAAGAGAATTGAGCAAAATATCTTCTACACGAAGAGTATGTTACTTG
AAAATGAAGATGTTGTAGATTATTTCGACTACAATTACAAGGGAAATGATTTAAAAATTCCTTACCATGATATTTTGTAT
ATTGAAACAACAGGGGTATCTCATAAATTGCGCATTATTGGTAAGAATTTTGCAAAAGAGTTTTATGGTACCATGACAGA
TATTCAGGAAAAGGACAAACATACTCAGCGATTTTATTCTCCTCACAAGTCATTTTTGGTAAATATAGGCAATATCAGAG
AAATTGATCGAAAAAACTTAGAAATTGTTTTCTATGAAGACCATCGTTGTCCTATTTCAAGATTAAAAATTAGAAAATTA
AAAGATATTTTAGAGAAAAAATCTCAAAAGTGA

Domains

Predicted by InterproScan.

• LytTr DNA-binding domain (LytTR) (151-244)

• Response regulator receiver domain (Response_reg) (3-121)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE	Streptococcus pneumoniae Rx1	100	100	1
comE	Streptococcus pneumoniae D39	100	100	1
comE	Streptococcus pneumoniae R6	100	100	1
comE	Streptococcus pneumoniae TIGR4	100	100	1
comE	Streptococcus mitis SK321	99.2	100	0.992
comE	Streptococcus mitis NCTC 12261	98.4	100	0.984
comE	Streptococcus infantis strain Atu-4	91.2	100	0.912
comE/comE2	Streptococcus gordonii strain NCTC7865	62.8	100	0.628
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	62.8	100	0.628
comE/blpR	Streptococcus mutans UA159	41.296	98.8	0.408