Detailed information    

insolico Bioinformatically predicted

Overview

Name   htrA   Type   Regulator
Locus tag   ABC812_RS10785 Genome accession   NZ_CP155537
Coordinates   2090996..2092177 (+) Length   393 a.a.
NCBI ID   WP_000681597.1    Uniprot ID   -
Organism   Streptococcus pneumoniae strain DP1322     
Function   degrading CSP; selective degradation of ComEA and ComEC (predicted from homology)   
Competence regulation

Genomic Context

Location: 2085996..2097177
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ABC812_RS10745 (ABC812_10740) - 2087047..2087589 (+) 543 WP_001158266.1 TetR/AcrR family transcriptional regulator -
  ABC812_RS10760 (ABC812_10755) comE 2087832..2088584 (-) 753 WP_000866065.1 competence system response regulator transcription factor ComE Regulator
  ABC812_RS10765 (ABC812_10760) comD/comD1 2088581..2089906 (-) 1326 WP_000362880.1 competence system sensor histidine kinase ComD Regulator
  ABC812_RS10770 (ABC812_10765) comC/comC1 2089927..2090052 (-) 126 WP_000799689.1 competence-stimulating peptide ComC Regulator
  ABC812_RS10780 (ABC812_10775) rlmH 2090334..2090813 (-) 480 WP_000695929.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  ABC812_RS10785 (ABC812_10780) htrA 2090996..2092177 (+) 1182 WP_000681597.1 trypsin-like peptidase domain-containing protein Regulator
  ABC812_RS10790 (ABC812_10785) spo0J 2092235..2092993 (+) 759 WP_000410378.1 ParB/RepB/Spo0J family partition protein Regulator
  ABC812_RS10795 (ABC812_10790) dnaA 2093206..2094567 (+) 1362 WP_000660615.1 chromosomal replication initiator protein DnaA -

Sequence

Protein


Download         Length: 393 a.a.        Molecular weight: 41841.72 Da        Isoelectric Point: 6.8902

>NTDB_id=997528 ABC812_RS10785 WP_000681597.1 2090996..2092177(+) (htrA) [Streptococcus pneumoniae strain DP1322]
MKHLKTFYKKWFQLLVVIVISFFSGALGSFSITQLTQKSSVNNSNNNSTITQTAYKNENSTTQAVNKVKDAVVSVITYSA
NRQNSVFGNDDTDTDSQRISSEGSGVIYKKNDKEAYIVTNNHVINGASKVDIRLSDGTKVPGEIVGADTFSDIAVVKISS
EKVTTVAEFGDSSKLTVGETAIAIGSPLGSEYANTVTQGIVSSLNRNVSLKSEDGQAISTKAIQTDTAINPGNSGGPLIN
IQGQVIGITSSKIATNGGTSVEGLGFAIPANDAINIIEQLEKNGKVTRPALGIQMVNLSNVSTSDIRRLNIPSNVTSGVI
VRSVQSNMPANGHLEKYDVITKVDDKEIASSTDLQSALYNHSIGDTIKITYYRNGKEETTSIKLNKSSGDLES

Nucleotide


Download         Length: 1182 bp        

>NTDB_id=997528 ABC812_RS10785 WP_000681597.1 2090996..2092177(+) (htrA) [Streptococcus pneumoniae strain DP1322]
ATGAAACATCTAAAAACATTTTACAAAAAATGGTTTCAATTATTAGTCGTTATCGTCATTAGCTTTTTTAGTGGAGCCTT
GGGTAGTTTTTCAATAACTCAACTAACTCAAAAAAGTAGTGTAAACAACTCTAACAACAATAGTACTATTACACAAACTG
CCTATAAGAACGAAAATTCAACAACACAGGCTGTTAACAAAGTAAAAGATGCTGTTGTTTCTGTTATTACTTATTCGGCA
AACAGACAAAATAGCGTATTTGGCAATGATGATACTGACACAGATTCTCAGCGAATCTCTAGTGAAGGATCTGGAGTTAT
TTATAAAAAGAATGATAAAGAAGCTTACATCGTCACCAACAATCACGTTATAAATGGCGCCAGCAAAGTAGATATTCGAT
TGTCAGATGGGACTAAAGTACCTGGAGAAATTGTCGGAGCTGACACTTTCTCTGATATTGCTGTCGTCAAAATCTCTTCA
GAAAAAGTGACAACAGTAGCTGAGTTTGGTGATTCTAGTAAGTTAACTGTAGGAGAAACTGCTATTGCCATCGGTAGCCC
GTTAGGTTCTGAATATGCAAATACTGTCACTCAAGGTATCGTATCCAGTCTCAATAGAAATGTATCCTTAAAATCGGAAG
ATGGACAAGCTATTTCTACAAAAGCCATCCAAACTGATACTGCTATTAACCCAGGTAACTCTGGCGGCCCACTGATCAAT
ATTCAAGGGCAGGTTATCGGAATTACCTCAAGTAAAATTGCTACAAATGGAGGAACATCTGTAGAAGGTCTTGGTTTCGC
AATTCCTGCAAATGATGCTATCAATATTATTGAACAGTTAGAAAAAAACGGAAAAGTGACGCGTCCAGCTTTGGGAATCC
AGATGGTTAATTTATCTAATGTGAGTACAAGCGACATCAGAAGACTCAATATTCCAAGTAATGTTACATCTGGTGTAATT
GTTCGTTCGGTACAAAGTAATATGCCTGCCAATGGTCACCTTGAAAAATACGATGTAATTACAAAAGTAGATGACAAAGA
GATTGCTTCATCAACAGACTTACAAAGTGCTCTTTACAACCATTCTATCGGAGACACCATTAAGATAACCTACTATCGTA
ACGGGAAAGAAGAAACTACCTCTATCAAACTTAACAAGAGTTCAGGTGATTTAGAATCTTAA

Domains

Predicted by InterproScan.

Trypsin-like peptidase domain (Trypsin_2)

(103-248)

PDZ domain (PDZ_2)

(289-384)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  htrA Streptococcus pneumoniae Rx1

100

100

1
  htrA Streptococcus pneumoniae D39

100

100

1
  htrA Streptococcus pneumoniae R6

100

100

1
  htrA Streptococcus pneumoniae TIGR4

100

100

1
  htrA Streptococcus mitis NCTC 12261

97.201

100

0.972
  htrA Streptococcus gordonii str. Challis substr. CH1

66.414

100

0.669
  htrA Streptococcus mutans UA159

54.569

100

0.547

Multiple sequence alignment