Detailed information NTG0989359

Bioinformatically predicted

Overview

• Name: comGC
• Type: Machinery gene
• Locus tag: HMPREF9319_RS00395
• Genome accession: NZ_GL397128
• Coordinates: 71051..71344 (+)
• Length: 97 a.a.
• NCBI ID: WP_003062921.1
• Uniprot ID: E0PB49
• Organism: Streptococcus equinus ATCC 700338
• Function: dsDNA binding to the cell surface; assembly of the pseudopilus (predicted from homology) DNA binding and uptake

Genomic Context

Location: 66051..76344

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
HMPREF9319_RS00380 (HMPREF9319_0069)	-	68710..69072 (+)	363	WP_003062916.1	DUF1033 family protein	-
HMPREF9319_RS00385 (HMPREF9319_0070)	comGA	69143..70084 (+)	942	WP_003062917.1	competence type IV pilus ATPase ComGA	Machinery gene
HMPREF9319_RS00390 (HMPREF9319_0071)	comGB	70008..71051 (+)	1044	WP_003062919.1	competence type IV pilus assembly protein ComGB	Machinery gene
HMPREF9319_RS00395 (HMPREF9319_0072)	comGC	71051..71344 (+)	294	WP_003062921.1	competence type IV pilus major pilin ComGC	Machinery gene
HMPREF9319_RS00400 (HMPREF9319_0073)	comGD	71328..71759 (+)	432	WP_003062922.1	competence type IV pilus minor pilin ComGD	Machinery gene
HMPREF9319_RS00405 (HMPREF9319_0074)	comGE	71713..72006 (+)	294	WP_080543606.1	competence type IV pilus minor pilin ComGE	Machinery gene
HMPREF9319_RS00410 (HMPREF9319_0075)	comGF	71990..72427 (+)	438	WP_041974065.1	competence type IV pilus minor pilin ComGF	Machinery gene
HMPREF9319_RS00415 (HMPREF9319_0076)	comGG	72399..72731 (+)	333	WP_003062925.1	competence type IV pilus minor pilin ComGG	Machinery gene
HMPREF9319_RS00420 (HMPREF9319_0077)	comGH	72786..73757 (+)	972	WP_003062926.1	class I SAM-dependent methyltransferase	Machinery gene
HMPREF9319_RS00425 (HMPREF9319_0078)	-	73795..74994 (+)	1200	WP_003062927.1	acetate kinase	-
HMPREF9319_RS00430 (HMPREF9319_0079)	-	75155..75355 (+)	201	WP_013851401.1	helix-turn-helix transcriptional regulator	-
HMPREF9319_RS00435 (HMPREF9319_0080)	-	75365..75574 (+)	210	WP_003062929.1	hypothetical protein	-
HMPREF9319_RS00440 (HMPREF9319_0081)	-	75587..76039 (+)	453	WP_003062930.1	hypothetical protein	-

Sequence

Protein

• Length: 97 a.a.
• Molecular weight: 10999.15 Da
• Isoelectric Point: 9.9310

>NTDB_id=989359 HMPREF9319_RS00395 WP_003062921.1 71051..71344(+) (comGC) [Streptococcus equinus ATCC 700338]
MKKIWKKLRKKSVAAFTLVEMLIVLLIISVLMLLFVPNLSKQKDVVREKGDAAVVKVVESQMDLYELKTGDKPTVDDLVE
VGYITSEQAKTYNEAKK

Nucleotide

• Length: 294 bp

>NTDB_id=989359 HMPREF9319_RS00395 WP_003062921.1 71051..71344(+) (comGC) [Streptococcus equinus ATCC 700338]
ATGAAAAAGATTTGGAAAAAATTACGTAAAAAGTCTGTGGCTGCTTTCACACTTGTGGAGATGTTGATTGTGCTTCTTAT
TATCAGTGTTTTAATGTTGCTTTTTGTACCGAATTTGAGTAAGCAAAAGGACGTTGTTCGTGAAAAAGGCGATGCTGCTG
TTGTGAAAGTGGTTGAAAGCCAGATGGATTTGTACGAACTGAAAACGGGAGATAAACCGACTGTTGATGATTTAGTTGAA
GTTGGCTACATCACTTCTGAACAAGCAAAAACTTACAATGAAGCTAAAAAATAA

Domains

Predicted by InterProScan.

• Prokaryotic N-terminal methylation motif (N_methyl) (11-34)

3D structure

• AlphaFold DB: E0PB49

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comGC	Streptococcus suis isolate S10	66.304	94.845	0.629
comGC/cglC	Streptococcus mitis SK321	62.766	96.907	0.608
comGC	Streptococcus gordonii str. Challis substr. CH1	67.045	90.722	0.608
comGC/cglC	Streptococcus pneumoniae D39	61.702	96.907	0.598
comGC/cglC	Streptococcus pneumoniae R6	61.702	96.907	0.598
comGC/cglC	Streptococcus pneumoniae TIGR4	61.702	96.907	0.598
comGC/cglC	Streptococcus pneumoniae Rx1	61.702	96.907	0.598
comGC/cglC	Streptococcus mitis NCTC 12261	61.702	96.907	0.598
comGC	Streptococcus mutans UA140	61.798	91.753	0.567
comGC	Streptococcus mutans UA159	61.798	91.753	0.567
comGC	Lactococcus lactis subsp. cremoris KW2	56.667	92.784	0.526
comGC	Staphylococcus aureus MW2	45.57	81.443	0.371
comGC	Staphylococcus aureus N315	45.57	81.443	0.371