Detailed information NTG0893224

Bioinformatically predicted

Overview

• Name: comE
• Type: Regulator
• Locus tag: R1Y14_RS01805
• Genome accession: NZ_CP136899
• Coordinates: 331216..331968 (-)
• Length: 250 a.a.
• NCBI ID: WP_000866065.1
• Uniprot ID: -
• Organism: Streptococcus pneumoniae strain ST62
• Function: activate transcription of early competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 326216..336968

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
R1Y14_RS01785 (R1Y14_01785)	-	328671..330303 (-)	1633	Protein_315	YhgE/Pip family protein	-
R1Y14_RS01790 (R1Y14_01790)	-	330431..330973 (+)	543	WP_001158266.1	TetR/AcrR family transcriptional regulator	-
R1Y14_RS01805 (R1Y14_01805)	comE	331216..331968 (-)	753	WP_000866065.1	competence system response regulator transcription factor ComE	Regulator
R1Y14_RS01810 (R1Y14_01810)	comD/comD1	331965..333290 (-)	1326	WP_001860404.1	competence system sensor histidine kinase ComD	Regulator
R1Y14_RS01815 (R1Y14_01815)	comC/comC1	333311..333436 (-)	126	WP_000799689.1	competence-stimulating peptide ComC	Regulator
R1Y14_RS01825 (R1Y14_01825)	rlmH	333719..334198 (-)	480	WP_000695929.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
R1Y14_RS01830 (R1Y14_01830)	htrA	334381..335562 (+)	1182	WP_000681601.1	S1C family serine protease	Regulator
R1Y14_RS01835 (R1Y14_01835)	spo0J	335620..336378 (+)	759	WP_000410378.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 250 a.a.
• Molecular weight: 29958.31 Da
• Isoelectric Point: 6.5073

>NTDB_id=893224 R1Y14_RS01805 WP_000866065.1 331216..331968(-) (comE) [Streptococcus pneumoniae strain ST62]
MKVLILEDVIEHQVRLERILDEISKESNIPISYKTTGKVREFEEYIENDEVNQLYFLDIDIHGIEKKGFEVAQLIRHYNP
YAIIVFITSRSEFATLTYKYQVSALDFVDKDINDEMFKKRIEQNIFYTKSMLLENEDVVDYFDYNYKGNDLKIPYHDILY
IETTGVSHKLRIIGKNFAKEFYGTMTDIQEKDKHTQRFYSPHKSFLVNIGNIREIDRKNLEIVFYEDHRCPISRLKIRKL
KDILEKKSQK

Nucleotide

• Length: 753 bp

>NTDB_id=893224 R1Y14_RS01805 WP_000866065.1 331216..331968(-) (comE) [Streptococcus pneumoniae strain ST62]
ATGAAAGTTTTAATTTTAGAAGATGTTATTGAACATCAAGTGAGACTAGAGAGAATATTGGATGAAATTTCGAAAGAATC
GAATATTCCAATATCATACAAGACAACGGGAAAAGTCCGTGAATTTGAAGAATACATTGAAAATGATGAAGTAAATCAGC
TTTATTTCCTAGATATCGATATTCATGGAATTGAGAAAAAGGGATTTGAAGTGGCTCAGCTCATTCGTCATTACAATCCT
TACGCTATTATCGTCTTTATCACTAGTCGATCAGAGTTTGCGACTCTAACCTATAAATACCAGGTATCAGCCCTAGATTT
TGTTGATAAGGATATCAATGATGAGATGTTTAAGAAGAGAATTGAGCAAAATATCTTCTACACGAAGAGTATGTTACTTG
AAAATGAAGATGTTGTAGATTATTTCGACTACAATTACAAGGGAAATGATTTAAAAATTCCTTACCATGATATTTTGTAT
ATTGAAACAACAGGGGTATCTCATAAATTGCGCATTATTGGTAAGAATTTTGCAAAAGAGTTTTATGGTACCATGACAGA
TATTCAGGAAAAGGACAAACATACTCAGCGATTTTATTCTCCTCACAAGTCATTTTTGGTAAATATAGGCAATATCAGAG
AAATTGATCGAAAAAACTTAGAAATTGTTTTCTATGAAGACCATCGTTGTCCTATTTCAAGATTAAAAATTAGAAAATTA
AAAGATATTTTAGAGAAAAAATCTCAAAAGTGA

Domains

Predicted by InterproScan.

• LytTr DNA-binding domain (LytTR) (151-244)

• Response regulator receiver domain (Response_reg) (3-121)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE	Streptococcus pneumoniae Rx1	100	100	1
comE	Streptococcus pneumoniae D39	100	100	1
comE	Streptococcus pneumoniae R6	100	100	1
comE	Streptococcus pneumoniae TIGR4	100	100	1
comE	Streptococcus mitis SK321	99.2	100	0.992
comE	Streptococcus mitis NCTC 12261	98.4	100	0.984
comE	Streptococcus infantis strain Atu-4	91.2	100	0.912
comE/comE2	Streptococcus gordonii strain NCTC7865	62.8	100	0.628
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	62.8	100	0.628
comE/blpR	Streptococcus mutans UA159	41.296	98.8	0.408