Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   SIY77_RS17455 Genome accession   NZ_CP139125
Coordinates   3558526..3559185 (-) Length   219 a.a.
NCBI ID   WP_001221493.1    Uniprot ID   Q3YXL4
Organism   Escherichia coli strain YZ22PE244     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 3553526..3564185
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SIY77_RS17430 parE 3553617..3555509 (+) 1893 WP_000195296.1 DNA topoisomerase IV subunit B -
  SIY77_RS17435 ygiN 3555557..3555871 (-) 315 WP_000958598.1 putative quinol monooxygenase -
  SIY77_RS17440 mdaB 3555902..3556483 (-) 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
  SIY77_RS17445 ygiZ 3556802..3557134 (+) 333 WP_000917684.1 DUF2645 family protein -
  SIY77_RS17450 qseC 3557180..3558529 (-) 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
  SIY77_RS17455 ciaR 3558526..3559185 (-) 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB Regulator
  SIY77_RS17460 ygiW 3559337..3559729 (+) 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
  SIY77_RS17465 ygiV 3559782..3560264 (+) 483 WP_000183505.1 GyrI-like domain-containing protein -
  SIY77_RS17470 mqsR 3560469..3560765 (+) 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR -
  SIY77_RS17475 mqsA 3560767..3561162 (+) 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA -
  SIY77_RS17480 ygiS 3561295..3562902 (+) 1608 WP_106631741.1 ABC transporter substrate-binding protein -

Sequence

Protein


Download         Length: 219 a.a.        Molecular weight: 24687.63 Da        Isoelectric Point: 6.9850

>NTDB_id=829316 SIY77_RS17455 WP_001221493.1 3558526..3559185(-) (ciaR) [Escherichia coli strain YZ22PE244]
MRILLIEDDMLIGDGIKTGLSKMGFSVDWFTQGRQGKEALYSAPYDAVILDLTLPGMDGRDILREWREKGQREPVLILTA
RDALAERVEGLRLGADDYLCKPFALIEVAARLEALMRRTNGQASNELRHGNVMLDPGKRIATLAGEPLTLKPKEFALLEL
LMRNAGRVLPRKLIEEKLYTWDEEVTSNAVEVHVHHLRRKLGSDFIRTVHGIGYTLGEK

Nucleotide


Download         Length: 660 bp        

>NTDB_id=829316 SIY77_RS17455 WP_001221493.1 3558526..3559185(-) (ciaR) [Escherichia coli strain YZ22PE244]
ATGCGAATTTTACTGATAGAAGATGACATGCTGATTGGCGACGGCATCAAAACGGGCCTTAGTAAAATGGGTTTTAGCGT
CGACTGGTTTACACAAGGTCGTCAGGGAAAAGAGGCGCTTTATAGCGCACCTTATGATGCGGTGATCCTGGATTTAACCT
TACCAGGCATGGATGGTCGCGATATTTTGCGCGAATGGCGAGAAAAAGGTCAGCGTGAGCCGGTACTGATCCTGACCGCG
CGCGATGCGCTGGCGGAACGTGTAGAAGGGCTGCGTCTGGGAGCTGACGATTATCTGTGTAAACCTTTTGCGTTGATAGA
AGTCGCCGCCAGGCTGGAAGCTCTGATGCGCCGAACCAACGGCCAGGCCAGCAACGAGCTGCGCCACGGTAACGTCATGC
TCGACCCCGGCAAACGTATCGCCACGCTGGCTGGCGAACCCTTAACACTGAAACCAAAAGAATTTGCCCTGCTGGAATTA
CTGATGCGTAACGCTGGTCGGGTACTGCCGCGCAAACTGATTGAAGAGAAACTGTATACCTGGGACGAAGAGGTCACCAG
TAATGCCGTTGAAGTGCATGTGCATCATCTGCGACGCAAACTCGGTAGTGATTTTATTCGTACCGTGCATGGTATTGGTT
ACACATTAGGTGAGAAATGA

Domains

Predicted by InterProScan.

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(145-216)

Response regulator receiver domain (Response_reg)

(3-112)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB Q3YXL4

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus pneumoniae Rx1

38.326

100

0.397
  ciaR Streptococcus pneumoniae D39

38.326

100

0.397
  ciaR Streptococcus pneumoniae R6

38.326

100

0.397
  ciaR Streptococcus pneumoniae TIGR4

38.326

100

0.397
  ciaR Streptococcus mutans UA159

35.874

100

0.365