Detailed information    

insolico Bioinformatically predicted

Overview

Name   comGC/cglC   Type   Machinery gene
Locus tag   QLQ53_RS09275 Genome accession   NZ_CP124911
Coordinates   1848443..1848718 (-) Length   91 a.a.
NCBI ID   WP_002356991.1    Uniprot ID   A0A1B4XPV0
Organism   Enterococcus faecalis strain EfsC61     
Function   dsDNA binding to the cell surface; assembly of the pseudopilus (predicted from homology)   
DNA binding and uptake

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Prophage 1805240..1848419 1848443..1848718 flank 24


Gene organization within MGE regions


Location: 1805240..1848718
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  QLQ53_RS08975 (QLQ53_08975) - 1805240..1806247 (-) 1008 WP_002372004.1 class I SAM-dependent methyltransferase -
  QLQ53_RS08980 (QLQ53_08980) comGG 1806376..1806729 (-) 354 WP_002369174.1 competence type IV pilus minor pilin ComGG -
  QLQ53_RS08985 (QLQ53_08985) comGF 1806729..1807163 (-) 435 WP_002362055.1 competence type IV pilus minor pilin ComGF -
  QLQ53_RS08990 (QLQ53_08990) - 1807153..1807554 (-) 402 WP_014862199.1 type II secretion system protein -
  QLQ53_RS08995 (QLQ53_08995) - 1807858..1807983 (+) 126 WP_002364184.1 hypothetical protein -
  QLQ53_RS09000 (QLQ53_09000) hemH 1808280..1809221 (-) 942 WP_002364185.1 ferrochelatase -
  QLQ53_RS09010 (QLQ53_09010) - 1809965..1810216 (-) 252 WP_002364188.1 hypothetical protein -
  QLQ53_RS09015 (QLQ53_09015) - 1810288..1810488 (-) 201 WP_002357053.1 cold-shock protein -
  QLQ53_RS09020 (QLQ53_09020) - 1811325..1812566 (-) 1242 WP_002394567.1 LysM peptidoglycan-binding domain-containing protein -
  QLQ53_RS09025 (QLQ53_09025) - 1812567..1812800 (-) 234 WP_002384371.1 phage holin -
  QLQ53_RS09030 (QLQ53_09030) - 1812793..1813014 (-) 222 WP_002364191.1 hypothetical protein -
  QLQ53_RS09035 (QLQ53_09035) - 1813049..1813204 (-) 156 WP_002394568.1 XkdX family protein -
  QLQ53_RS09040 (QLQ53_09040) - 1813206..1813526 (-) 321 WP_002394569.1 hypothetical protein -
  QLQ53_RS09045 (QLQ53_09045) - 1813545..1814087 (-) 543 WP_002394570.1 hypothetical protein -
  QLQ53_RS09050 (QLQ53_09050) - 1814087..1814374 (-) 288 WP_002394572.1 hypothetical protein -
  QLQ53_RS09055 (QLQ53_09055) - 1814371..1814967 (-) 597 WP_025191462.1 hypothetical protein -
  QLQ53_RS09060 (QLQ53_09060) - 1814960..1815841 (-) 882 WP_010729977.1 phage baseplate upper protein -
  QLQ53_RS09065 (QLQ53_09065) - 1815860..1818667 (-) 2808 WP_025191463.1 phage tail spike protein -
  QLQ53_RS09070 (QLQ53_09070) - 1818649..1819383 (-) 735 WP_002380434.1 hypothetical protein -
  QLQ53_RS09075 (QLQ53_09075) - 1819373..1822270 (-) 2898 WP_002393612.1 tape measure protein -
  QLQ53_RS09080 (QLQ53_09080) - 1822518..1822868 (-) 351 WP_002357039.1 hypothetical protein -
  QLQ53_RS09085 (QLQ53_09085) - 1822921..1823769 (-) 849 WP_002387287.1 major tail protein -
  QLQ53_RS09090 (QLQ53_09090) - 1823770..1824144 (-) 375 WP_002393979.1 DUF6838 family protein -
  QLQ53_RS09095 (QLQ53_09095) - 1824147..1824545 (-) 399 WP_002357036.1 HK97 gp10 family phage protein -
  QLQ53_RS09100 (QLQ53_09100) - 1824538..1824906 (-) 369 WP_002393978.1 hypothetical protein -
  QLQ53_RS09105 (QLQ53_09105) - 1824903..1825247 (-) 345 WP_002357033.1 hypothetical protein -
  QLQ53_RS09110 (QLQ53_09110) - 1825261..1825443 (-) 183 WP_002357032.1 hypothetical protein -
  QLQ53_RS09115 (QLQ53_09115) - 1825472..1826359 (-) 888 WP_002357030.1 DUF5309 domain-containing protein -
  QLQ53_RS09120 (QLQ53_09120) - 1826373..1826996 (-) 624 WP_002393977.1 DUF4355 domain-containing protein -
  QLQ53_RS09125 (QLQ53_09125) - 1827215..1827535 (-) 321 WP_002380436.1 hypothetical protein -
  QLQ53_RS09130 (QLQ53_09130) - 1827592..1827822 (-) 231 WP_002380437.1 hypothetical protein -
  QLQ53_RS09135 (QLQ53_09135) - 1827823..1829727 (-) 1905 WP_002393613.1 hypothetical protein -
  QLQ53_RS09140 (QLQ53_09140) - 1829702..1831189 (-) 1488 WP_002393614.1 phage portal protein -
  QLQ53_RS09145 (QLQ53_09145) - 1831201..1832490 (-) 1290 WP_002393615.1 PBSX family phage terminase large subunit -
  QLQ53_RS09150 (QLQ53_09150) terS 1832462..1833265 (-) 804 WP_002372038.1 phage terminase small subunit -
  QLQ53_RS09155 (QLQ53_09155) - 1833312..1834028 (-) 717 WP_002372040.1 hypothetical protein -
  QLQ53_RS09160 (QLQ53_09160) - 1834121..1834348 (-) 228 WP_002372042.1 hypothetical protein -
  QLQ53_RS09170 (QLQ53_09170) - 1836446..1836862 (-) 417 WP_002372045.1 ArpU family phage packaging/lysis transcriptional regulator -
  QLQ53_RS09175 (QLQ53_09175) - 1837769..1838203 (-) 435 WP_002372046.1 RusA family crossover junction endodeoxyribonuclease -
  QLQ53_RS09180 (QLQ53_09180) - 1838212..1838511 (-) 300 WP_002372047.1 MazG-like family protein -
  QLQ53_RS09185 (QLQ53_09185) - 1838512..1838814 (-) 303 WP_002368214.1 hypothetical protein -
  QLQ53_RS09190 (QLQ53_09190) - 1838818..1839780 (-) 963 WP_002372048.1 Lin1244/Lin1753 domain-containing protein -
  QLQ53_RS09195 (QLQ53_09195) - 1839794..1840684 (-) 891 WP_002364218.1 recombinase RecT -
  QLQ53_RS09200 (QLQ53_09200) - 1840687..1841628 (-) 942 WP_002364219.1 lambda-exonuclease family protein -
  QLQ53_RS09205 (QLQ53_09205) - 1841726..1841953 (-) 228 WP_002364220.1 hypothetical protein -
  QLQ53_RS09210 (QLQ53_09210) - 1841953..1842276 (-) 324 WP_002380444.1 hypothetical protein -
  QLQ53_RS09215 (QLQ53_09215) - 1842320..1842505 (-) 186 WP_002364222.1 hypothetical protein -
  QLQ53_RS09220 (QLQ53_09220) - 1842496..1842690 (-) 195 WP_002364223.1 hypothetical protein -
  QLQ53_RS09225 (QLQ53_09225) - 1842743..1842925 (+) 183 WP_002364224.1 YegP family protein -
  QLQ53_RS09230 (QLQ53_09230) - 1842965..1843687 (-) 723 WP_002364225.1 phage regulatory protein -
  QLQ53_RS09235 (QLQ53_09235) - 1843726..1844043 (-) 318 WP_002364228.1 hypothetical protein -
  QLQ53_RS09240 (QLQ53_09240) - 1844049..1844240 (-) 192 WP_002356998.1 hypothetical protein -
  QLQ53_RS09245 (QLQ53_09245) - 1844530..1844874 (+) 345 WP_002385819.1 helix-turn-helix transcriptional regulator -
  QLQ53_RS09250 (QLQ53_09250) - 1844879..1845526 (+) 648 WP_002372050.1 ImmA/IrrE family metallo-endopeptidase -
  QLQ53_RS09255 (QLQ53_09255) - 1845644..1846408 (+) 765 WP_002389030.1 LysM domain-containing protein -
  QLQ53_RS09260 (QLQ53_09260) - 1846423..1846752 (+) 330 WP_002369911.1 hypothetical protein -
  QLQ53_RS09265 (QLQ53_09265) - 1846827..1847975 (+) 1149 WP_002389015.1 site-specific integrase -
  QLQ53_RS09270 (QLQ53_09270) comGD 1848003..1848446 (-) 444 WP_002369912.1 competence type IV pilus minor pilin ComGD -
  QLQ53_RS09275 (QLQ53_09275) comGC/cglC 1848443..1848718 (-) 276 WP_002356991.1 competence type IV pilus major pilin ComGC Machinery gene

Sequence

Protein


Download         Length: 91 a.a.        Molecular weight: 10464.41 Da        Isoelectric Point: 9.3192

>NTDB_id=829204 QLQ53_RS09275 WP_002356991.1 1848443..1848718(-) (comGC/cglC) [Enterococcus faecalis strain EfsC61]
MKKKQKYAGFTLLEMLIVLLIISVLILLFVPNLAKHKETVDKKGNEAIVKIVESQIELYTLEKNKTPSLNELVNEGYITK
EQLDKYTAEKQ

Nucleotide


Download         Length: 276 bp        

>NTDB_id=829204 QLQ53_RS09275 WP_002356991.1 1848443..1848718(-) (comGC/cglC) [Enterococcus faecalis strain EfsC61]
ATGAAAAAGAAACAAAAATACGCAGGGTTTACATTATTAGAAATGTTGATTGTCTTATTGATTATTTCCGTATTGATTTT
ACTTTTTGTTCCTAACTTAGCGAAACATAAAGAAACAGTTGATAAAAAAGGCAATGAAGCAATCGTAAAAATTGTAGAAT
CACAAATCGAGCTCTACACACTAGAAAAAAATAAGACGCCTTCTTTAAATGAATTAGTCAACGAAGGCTACATTACTAAA
GAGCAGTTAGATAAATATACAGCAGAAAAGCAATGA

Domains

Predicted by InterproScan.

Prokaryotic N-terminal methylation motif (N_methyl)

(5-28)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A1B4XPV0

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comGC/cglC Streptococcus pneumoniae Rx1

63.095

92.308

0.582
  comGC/cglC Streptococcus pneumoniae D39

63.095

92.308

0.582
  comGC/cglC Streptococcus pneumoniae R6

63.095

92.308

0.582
  comGC/cglC Streptococcus pneumoniae TIGR4

63.095

92.308

0.582
  comGC/cglC Streptococcus mitis NCTC 12261

61.905

92.308

0.571
  comGC/cglC Streptococcus mitis SK321

61.176

93.407

0.571
  comGC Lactococcus lactis subsp. cremoris KW2

58.14

94.505

0.549
  comYC Streptococcus gordonii str. Challis substr. CH1

56.322

95.604

0.538
  comYC Streptococcus suis isolate S10

52.326

94.505

0.495
  comYC Streptococcus mutans UA159

57.692

85.714

0.495
  comYC Streptococcus mutans UA140

57.692

85.714

0.495
  comGC Latilactobacillus sakei subsp. sakei 23K

46.154

100

0.462
  comGC Staphylococcus aureus MW2

46.835

86.813

0.407
  comGC Staphylococcus aureus N315

46.835

86.813

0.407
  comGC Bacillus subtilis subsp. subtilis str. 168

48.649

81.319

0.396