Detailed information    

insolico Bioinformatically predicted

Overview

Name   comGC/cglC   Type   Machinery gene
Locus tag   QLQ59_RS08490 Genome accession   NZ_CP124906
Coordinates   1723668..1723943 (-) Length   91 a.a.
NCBI ID   WP_002356991.1    Uniprot ID   A0A1B4XPV0
Organism   Enterococcus faecalis strain EfsC49     
Function   dsDNA binding to the cell surface; assembly of the pseudopilus (predicted from homology)   
DNA binding and uptake

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Prophage 1683655..1742049 1723668..1723943 within 0


Gene organization within MGE regions


Location: 1683655..1742049
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  QLQ59_RS08225 (QLQ59_08225) - 1683655..1684662 (-) 1008 WP_002357063.1 class I SAM-dependent methyltransferase -
  QLQ59_RS08230 (QLQ59_08230) comGG 1684791..1685144 (-) 354 WP_002357061.1 competence type IV pilus minor pilin ComGG -
  QLQ59_RS08235 (QLQ59_08235) comGF 1685144..1685578 (-) 435 WP_002357060.1 competence type IV pilus minor pilin ComGF -
  QLQ59_RS08240 (QLQ59_08240) - 1685568..1685939 (-) 372 WP_002365830.1 type II secretion system protein -
  QLQ59_RS08245 (QLQ59_08245) hemH 1686696..1687637 (-) 942 WP_033628510.1 ferrochelatase -
  QLQ59_RS08255 (QLQ59_08255) - 1688380..1688631 (-) 252 WP_002364188.1 hypothetical protein -
  QLQ59_RS08260 (QLQ59_08260) - 1688704..1688904 (-) 201 WP_010783753.1 cold-shock protein -
  QLQ59_RS08265 (QLQ59_08265) - 1689740..1690999 (-) 1260 WP_010783754.1 LysM peptidoglycan-binding domain-containing protein -
  QLQ59_RS08270 (QLQ59_08270) - 1691053..1691451 (-) 399 WP_002358058.1 phage holin family protein -
  QLQ59_RS08275 (QLQ59_08275) - 1691481..1692017 (-) 537 WP_002397775.1 hypothetical protein -
  QLQ59_RS08280 (QLQ59_08280) - 1692018..1693046 (-) 1029 WP_002397774.1 hypothetical protein -
  QLQ59_RS08285 (QLQ59_08285) - 1693057..1694181 (-) 1125 WP_002381461.1 siphovirus ReqiPepy6 Gp37-like family protein -
  QLQ59_RS08290 (QLQ59_08290) - 1694184..1695083 (-) 900 WP_002371567.1 phage tail domain-containing protein -
  QLQ59_RS08295 (QLQ59_08295) - 1695083..1699834 (-) 4752 WP_010783756.1 phage tail tape measure protein -
  QLQ59_RS08300 (QLQ59_08300) - 1699853..1699975 (-) 123 WP_258078087.1 hypothetical protein -
  QLQ59_RS08305 (QLQ59_08305) - 1700056..1700403 (-) 348 WP_010783757.1 hypothetical protein -
  QLQ59_RS08310 (QLQ59_08310) - 1700460..1700933 (-) 474 WP_113816989.1 Ig-like domain-containing protein -
  QLQ59_RS08315 (QLQ59_08315) - 1701007..1701600 (-) 594 WP_282874079.1 major tail protein -
  QLQ59_RS08320 (QLQ59_08320) - 1701633..1702028 (-) 396 WP_010783759.1 hypothetical protein -
  QLQ59_RS08325 (QLQ59_08325) - 1702025..1702429 (-) 405 WP_010783760.1 hypothetical protein -
  QLQ59_RS08330 (QLQ59_08330) - 1702426..1702800 (-) 375 WP_002404844.1 hypothetical protein -
  QLQ59_RS08335 (QLQ59_08335) - 1702787..1703092 (-) 306 WP_002358075.1 hypothetical protein -
  QLQ59_RS08340 (QLQ59_08340) - 1703170..1704315 (-) 1146 WP_010783761.1 phage major capsid protein -
  QLQ59_RS08345 (QLQ59_08345) - 1704342..1705109 (-) 768 WP_025192979.1 head maturation protease, ClpP-related -
  QLQ59_RS08350 (QLQ59_08350) - 1705087..1706262 (-) 1176 WP_010784026.1 phage portal protein -
  QLQ59_RS08355 (QLQ59_08355) - 1706525..1708204 (-) 1680 WP_010783765.1 terminase TerL endonuclease subunit -
  QLQ59_RS08360 (QLQ59_08360) - 1708201..1708512 (-) 312 WP_002358082.1 P27 family phage terminase small subunit -
  QLQ59_RS08365 (QLQ59_08365) - 1708605..1709276 (-) 672 WP_002371590.1 HNH endonuclease -
  QLQ59_RS08370 (QLQ59_08370) - 1709395..1709709 (-) 315 WP_025192980.1 HNH endonuclease -
  QLQ59_RS08375 (QLQ59_08375) - 1709706..1710035 (-) 330 WP_010783766.1 hypothetical protein -
  QLQ59_RS08380 (QLQ59_08380) - 1710108..1710854 (-) 747 WP_010783767.1 hypothetical protein -
  QLQ59_RS08385 (QLQ59_08385) - 1711230..1711697 (-) 468 WP_010783768.1 ArpU family phage packaging/lysis transcriptional regulator -
  QLQ59_RS08390 (QLQ59_08390) - 1712360..1712566 (-) 207 WP_016633422.1 hypothetical protein -
  QLQ59_RS08395 (QLQ59_08395) - 1712582..1713187 (-) 606 WP_010709305.1 hypothetical protein -
  QLQ59_RS08400 (QLQ59_08400) - 1713207..1713677 (-) 471 WP_010709304.1 DUF1064 domain-containing protein -
  QLQ59_RS08405 (QLQ59_08405) - 1713826..1714095 (-) 270 WP_010706851.1 hypothetical protein -
  QLQ59_RS08410 (QLQ59_08410) - 1714234..1715073 (-) 840 WP_010783769.1 ATP-binding protein -
  QLQ59_RS08415 (QLQ59_08415) - 1715085..1715840 (-) 756 WP_002391449.1 DnaD domain protein -
  QLQ59_RS08420 (QLQ59_08420) - 1715855..1716670 (-) 816 WP_010783770.1 PD-(D/E)XK nuclease-like domain-containing protein -
  QLQ59_RS08425 (QLQ59_08425) - 1716633..1717649 (-) 1017 WP_010783771.1 RecT family recombinase -
  QLQ59_RS08430 (QLQ59_08430) - 1717752..1717976 (-) 225 WP_002391454.1 hypothetical protein -
  QLQ59_RS08435 (QLQ59_08435) - 1717973..1718296 (-) 324 WP_010783772.1 hypothetical protein -
  QLQ59_RS08440 (QLQ59_08440) - 1718336..1718551 (-) 216 WP_010783773.1 hypothetical protein -
  QLQ59_RS08445 (QLQ59_08445) - 1718558..1718869 (-) 312 WP_002381719.1 hypothetical protein -
  QLQ59_RS08450 (QLQ59_08450) - 1718880..1719056 (-) 177 WP_002364354.1 helix-turn-helix transcriptional regulator -
  QLQ59_RS08455 (QLQ59_08455) - 1719368..1719700 (+) 333 WP_002364355.1 helix-turn-helix transcriptional regulator -
  QLQ59_RS08460 (QLQ59_08460) - 1719717..1720061 (+) 345 WP_002364356.1 ImmA/IrrE family metallo-endopeptidase -
  QLQ59_RS08465 (QLQ59_08465) - 1720155..1721060 (+) 906 WP_016630909.1 DUF4352 domain-containing protein -
  QLQ59_RS08470 (QLQ59_08470) - 1721120..1721194 (+) 75 Protein_1643 ImmA/IrrE family metallo-endopeptidase -
  QLQ59_RS08475 (QLQ59_08475) - 1721228..1721956 (+) 729 WP_002364358.1 potassium channel family protein -
  QLQ59_RS08480 (QLQ59_08480) - 1722052..1723200 (+) 1149 WP_010783774.1 site-specific integrase -
  QLQ59_RS08485 (QLQ59_08485) comGD 1723228..1723671 (-) 444 WP_025189979.1 competence type IV pilus minor pilin ComGD -
  QLQ59_RS08490 (QLQ59_08490) comGC/cglC 1723668..1723943 (-) 276 WP_002356991.1 competence type IV pilus major pilin ComGC Machinery gene
  QLQ59_RS08495 (QLQ59_08495) comGB 1723943..1724989 (-) 1047 WP_002356990.1 competence type IV pilus assembly protein ComGB -
  QLQ59_RS08500 (QLQ59_08500) comGA 1724946..1725914 (-) 969 WP_002364362.1 competence type IV pilus ATPase ComGA -
  QLQ59_RS08505 (QLQ59_08505) - 1726155..1727483 (-) 1329 WP_002356988.1 amino acid permease -
  QLQ59_RS08510 (QLQ59_08510) rlmN 1727773..1728846 (-) 1074 WP_002356987.1 23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN -
  QLQ59_RS08515 (QLQ59_08515) - 1728972..1730801 (-) 1830 WP_002392355.1 ABC transporter permease -
  QLQ59_RS08520 (QLQ59_08520) - 1730791..1731540 (-) 750 WP_002381711.1 ABC transporter ATP-binding protein -
  QLQ59_RS08525 (QLQ59_08525) - 1731658..1732359 (-) 702 WP_002356983.1 GntR family transcriptional regulator -
  QLQ59_RS08530 (QLQ59_08530) - 1732489..1734912 (-) 2424 WP_002364367.1 DNA translocase FtsK -
  QLQ59_RS08535 (QLQ59_08535) - 1735226..1736437 (-) 1212 WP_002360017.1 NAD(P)/FAD-dependent oxidoreductase -
  QLQ59_RS08540 (QLQ59_08540) - 1736466..1737371 (-) 906 WP_002360016.1 prenyltransferase -
  QLQ59_RS08545 (QLQ59_08545) - 1737493..1738473 (+) 981 WP_002356979.1 polyprenyl synthetase family protein -
  QLQ59_RS08550 (QLQ59_08550) cydC 1738553..1740319 (-) 1767 WP_002364368.1 thiol reductant ABC exporter subunit CydC -
  QLQ59_RS08555 (QLQ59_08555) cydD 1740316..1742049 (-) 1734 WP_002364369.1 thiol reductant ABC exporter subunit CydD -

Sequence

Protein


Download         Length: 91 a.a.        Molecular weight: 10464.41 Da        Isoelectric Point: 9.3192

>NTDB_id=829129 QLQ59_RS08490 WP_002356991.1 1723668..1723943(-) (comGC/cglC) [Enterococcus faecalis strain EfsC49]
MKKKQKYAGFTLLEMLIVLLIISVLILLFVPNLAKHKETVDKKGNEAIVKIVESQIELYTLEKNKTPSLNELVNEGYITK
EQLDKYTAEKQ

Nucleotide


Download         Length: 276 bp        

>NTDB_id=829129 QLQ59_RS08490 WP_002356991.1 1723668..1723943(-) (comGC/cglC) [Enterococcus faecalis strain EfsC49]
ATGAAAAAGAAACAAAAATACGCAGGGTTTACATTATTAGAAATGTTGATTGTCTTATTGATTATTTCCGTATTGATTTT
ACTTTTTGTCCCTAACTTAGCGAAACATAAAGAAACAGTTGATAAAAAAGGCAATGAAGCAATCGTAAAAATTGTAGAAT
CACAAATCGAGCTCTACACACTAGAAAAAAATAAGACGCCTTCCTTAAATGAATTAGTCAACGAAGGCTACATTACTAAA
GAGCAGTTAGATAAATATACAGCAGAAAAGCAATGA

Domains

Predicted by InterproScan.

Prokaryotic N-terminal methylation motif (N_methyl)

(5-28)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A1B4XPV0

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comGC/cglC Streptococcus pneumoniae Rx1

63.095

92.308

0.582
  comGC/cglC Streptococcus pneumoniae D39

63.095

92.308

0.582
  comGC/cglC Streptococcus pneumoniae R6

63.095

92.308

0.582
  comGC/cglC Streptococcus pneumoniae TIGR4

63.095

92.308

0.582
  comGC/cglC Streptococcus mitis NCTC 12261

61.905

92.308

0.571
  comGC/cglC Streptococcus mitis SK321

61.176

93.407

0.571
  comGC Lactococcus lactis subsp. cremoris KW2

58.14

94.505

0.549
  comYC Streptococcus gordonii str. Challis substr. CH1

56.322

95.604

0.538
  comYC Streptococcus suis isolate S10

52.326

94.505

0.495
  comYC Streptococcus mutans UA159

57.692

85.714

0.495
  comYC Streptococcus mutans UA140

57.692

85.714

0.495
  comGC Latilactobacillus sakei subsp. sakei 23K

46.154

100

0.462
  comGC Staphylococcus aureus MW2

46.835

86.813

0.407
  comGC Staphylococcus aureus N315

46.835

86.813

0.407
  comGC Bacillus subtilis subsp. subtilis str. 168

48.649

81.319

0.396