Detailed information    

insolico Bioinformatically predicted

Overview

Name   comE/blpR   Type   Regulator
Locus tag   P7Y79_RS00515 Genome accession   NZ_CP121207
Coordinates   114713..115447 (+) Length   244 a.a.
NCBI ID   WP_133017806.1    Uniprot ID   A0A6G8HZI3
Organism   Streptococcus ruminicola strain CNU_77-47     
Function   activate transcription of early competence genes; regulation of comX expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 109713..120447
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  P7Y79_RS00490 (P7Y79_00490) - 110148..110612 (-) 465 WP_074560991.1 small multi-drug export protein -
  P7Y79_RS00495 (P7Y79_00495) - 110870..111331 (+) 462 WP_166043492.1 CtsR family transcriptional regulator -
  P7Y79_RS00500 (P7Y79_00500) clpC 111328..113769 (+) 2442 WP_278007526.1 ATP-dependent Clp protease ATP-binding subunit Regulator
  P7Y79_RS00505 (P7Y79_00505) - 113826..114185 (-) 360 WP_166043488.1 hypothetical protein -
  P7Y79_RS00510 (P7Y79_00510) - 114371..114703 (+) 333 WP_166043486.1 LytTR family transcriptional regulator DNA-binding domain-containing protein -
  P7Y79_RS00515 (P7Y79_00515) comE/blpR 114713..115447 (+) 735 WP_133017806.1 response regulator transcription factor Regulator
  P7Y79_RS00520 (P7Y79_00520) - 115451..116809 (+) 1359 WP_278007527.1 GHKL domain-containing protein -
  P7Y79_RS00525 (P7Y79_00525) - 116954..117700 (+) 747 WP_157629448.1 hypothetical protein -
  P7Y79_RS00530 (P7Y79_00530) - 117728..118600 (+) 873 WP_278007528.1 ABC transporter ATP-binding protein -
  P7Y79_RS00535 (P7Y79_00535) - 118733..119374 (+) 642 WP_157629446.1 hypothetical protein -
  P7Y79_RS00540 (P7Y79_00540) dusB 119417..120394 (-) 978 WP_157629445.1 tRNA dihydrouridine synthase DusB -

Sequence

Protein


Download         Length: 244 a.a.        Molecular weight: 28409.33 Da        Isoelectric Point: 5.4115

>NTDB_id=811073 P7Y79_RS00515 WP_133017806.1 114713..115447(+) (comE/blpR) [Streptococcus ruminicola strain CNU_77-47]
MLNIFVLEDDFFQQSRLEQAINRCMKENQLKYRQLEIFGKPQQLLEAIKEQGNHQFFFLDIEIKGEEKKGMEIAREIRAK
DPNAVIVFVTTHSEFMPVTYKYRVAALDFIDKGLNEEEFQEAVSSVLVYAFENVDTTVASDAFVFKNEHSHVQVPFSDIL
YFETSSTIHKVILTTKTGHMEFYGKVSDIAKADERLYQSHRAYVVNPENVTKIDRTNHIVYFEGDESCFVSRLKLKGLIE
RVEK

Nucleotide


Download         Length: 735 bp        

>NTDB_id=811073 P7Y79_RS00515 WP_133017806.1 114713..115447(+) (comE/blpR) [Streptococcus ruminicola strain CNU_77-47]
ATGCTAAATATCTTTGTGTTAGAGGATGATTTTTTCCAACAATCACGTTTGGAACAAGCTATTAATCGTTGTATGAAAGA
AAATCAACTGAAATACCGTCAGTTGGAGATTTTTGGGAAGCCTCAACAGCTTTTGGAAGCTATCAAGGAACAAGGGAATC
ATCAATTTTTTTTCTTAGATATTGAAATTAAAGGAGAAGAGAAAAAAGGAATGGAGATTGCGCGTGAAATTCGTGCTAAA
GACCCTAATGCAGTGATTGTTTTTGTGACGACGCACTCTGAATTTATGCCAGTAACTTATAAGTACCGTGTAGCGGCACT
TGATTTTATTGATAAAGGGCTAAATGAAGAGGAGTTTCAAGAGGCAGTATCATCTGTTTTAGTATATGCTTTTGAAAATG
TCGATACCACAGTAGCAAGTGATGCCTTTGTCTTTAAAAACGAGCATTCACACGTTCAAGTTCCTTTTTCGGATATTTTG
TACTTCGAGACATCATCAACAATTCACAAAGTTATTTTAACCACAAAAACAGGGCATATGGAATTTTATGGCAAGGTTTC
AGATATCGCAAAAGCAGACGAACGTCTTTACCAAAGTCACCGTGCCTATGTCGTTAATCCAGAAAATGTTACCAAAATCG
ATCGCACCAACCATATCGTCTACTTCGAAGGCGATGAATCGTGCTTTGTGTCACGCCTGAAACTAAAAGGATTAATCGAA
AGAGTGGAGAAATAG

Domains

Predicted by InterproScan.

LytTr DNA-binding domain (LytTR)

(152-241)

Response regulator receiver domain (Response_reg)

(4-123)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A6G8HZI3

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comE/blpR Streptococcus mutans UA159

57.741

97.951

0.566
  comE/comE1 Streptococcus equinus JB1

47.28

97.951

0.463
  comE/comE2 Streptococcus equinus JB1

39.918

99.59

0.398
  comE Streptococcus infantis strain Atu-4

37.6

100

0.385
  comE Streptococcus mitis SK321

37.6

100

0.385
  comE Streptococcus pneumoniae Rx1

37.6

100

0.385
  comE Streptococcus pneumoniae D39

37.6

100

0.385
  comE Streptococcus pneumoniae R6

37.6

100

0.385
  comE Streptococcus pneumoniae TIGR4

37.6

100

0.385
  comE Streptococcus mitis NCTC 12261

37.6

100

0.385
  comE/comE2 Streptococcus gordonii strain NCTC7865

36.885

100

0.369
  comE/comE1 Streptococcus gordonii str. Challis substr. CH1

36.885

100

0.369