Detailed information NTG0761427

Bioinformatically predicted

Overview

• Name: comE
• Type: Regulator
• Locus tag: OS912_RS06375
• Genome accession: NZ_CP113266
• Coordinates: 1252739..1253491 (-)
• Length: 250 a.a.
• NCBI ID: WP_000866065.1
• Uniprot ID: -
• Organism: Streptococcus pneumoniae strain BC1
• Function: activate transcription of early competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1247739..1258491

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
OS912_RS10965	-	1250178..1251775 (-)	1598	Protein_1221	YhgE/Pip family protein	-
OS912_RS06360 (OS912_06365)	-	1251954..1252496 (+)	543	WP_001863823.1	TetR/AcrR family transcriptional regulator	-
OS912_RS06375 (OS912_06380)	comE	1252739..1253491 (-)	753	WP_000866065.1	competence system response regulator transcription factor ComE	Regulator
OS912_RS06380 (OS912_06385)	comD/comD2	1253488..1254813 (-)	1326	WP_000364846.1	competence system sensor histidine kinase ComD	Regulator
OS912_RS06385 (OS912_06390)	comC/comC2	1254834..1254959 (-)	126	WP_000799686.1	competence-stimulating peptide ComC	Regulator
OS912_RS06395 (OS912_06400)	rlmH	1255241..1255720 (-)	480	WP_000695929.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
OS912_RS06400 (OS912_06405)	htrA	1255903..1257084 (+)	1182	WP_000681597.1	S1C family serine protease	Regulator
OS912_RS06405 (OS912_06410)	spo0J	1257142..1257900 (+)	759	WP_000410380.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 250 a.a.
• Molecular weight: 29958.31 Da
• Isoelectric Point: 6.5073

>NTDB_id=761427 OS912_RS06375 WP_000866065.1 1252739..1253491(-) (comE) [Streptococcus pneumoniae strain BC1]
MKVLILEDVIEHQVRLERILDEISKESNIPISYKTTGKVREFEEYIENDEVNQLYFLDIDIHGIEKKGFEVAQLIRHYNP
YAIIVFITSRSEFATLTYKYQVSALDFVDKDINDEMFKKRIEQNIFYTKSMLLENEDVVDYFDYNYKGNDLKIPYHDILY
IETTGVSHKLRIIGKNFAKEFYGTMTDIQEKDKHTQRFYSPHKSFLVNIGNIREIDRKNLEIVFYEDHRCPISRLKIRKL
KDILEKKSQK

Nucleotide

• Length: 753 bp

>NTDB_id=761427 OS912_RS06375 WP_000866065.1 1252739..1253491(-) (comE) [Streptococcus pneumoniae strain BC1]
ATGAAAGTTTTAATTTTAGAAGATGTTATTGAACATCAAGTGAGACTAGAGAGAATATTGGATGAAATTTCGAAAGAATC
GAATATTCCAATATCATACAAGACAACGGGAAAAGTCCGTGAATTTGAAGAATACATTGAAAATGATGAAGTAAATCAAC
TTTATTTCCTAGATATCGATATTCATGGAATTGAGAAAAAGGGATTTGAAGTGGCTCAGCTCATTCGTCATTACAATCCT
TACGCTATTATCGTCTTTATCACTAGTCGATCAGAGTTTGCGACTCTAACCTATAAATACCAGGTATCAGCCCTAGATTT
TGTTGATAAGGATATCAATGATGAGATGTTTAAGAAGAGAATTGAGCAAAATATCTTCTACACGAAGAGTATGTTACTTG
AAAATGAAGATGTTGTAGATTATTTCGACTACAATTACAAGGGAAATGATTTAAAAATTCCTTACCATGATATTTTGTAT
ATTGAAACAACAGGGGTATCTCATAAATTGCGCATTATTGGTAAGAATTTTGCAAAAGAGTTTTATGGTACCATGACAGA
TATTCAGGAAAAGGACAAACATACTCAGCGATTTTATTCTCCTCACAAGTCATTTTTGGTAAATATAGGCAATATCAGAG
AAATTGATCGAAAAAACTTAGAAATTGTTTTCTATGAAGACCATCGTTGTCCTATTTCAAGATTAAAAATTAGAAAATTA
AAAGATATTTTAGAGAAAAAATCTCAAAAGTGA

Domains

Predicted by InterproScan.

• LytTr DNA-binding domain (LytTR) (151-244)

• Response regulator receiver domain (Response_reg) (3-121)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE	Streptococcus pneumoniae Rx1	100	100	1
comE	Streptococcus pneumoniae D39	100	100	1
comE	Streptococcus pneumoniae R6	100	100	1
comE	Streptococcus pneumoniae TIGR4	100	100	1
comE	Streptococcus mitis SK321	99.2	100	0.992
comE	Streptococcus mitis NCTC 12261	98.4	100	0.984
comE	Streptococcus infantis strain Atu-4	91.2	100	0.912
comE/comE2	Streptococcus gordonii strain NCTC7865	62.8	100	0.628
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	62.8	100	0.628
comE/blpR	Streptococcus mutans UA159	41.296	98.8	0.408