Detailed information    

insolico Bioinformatically predicted

Overview

Name   comD/comD2   Type   Regulator
Locus tag   OS912_RS06380 Genome accession   NZ_CP113266
Coordinates   1253488..1254813 (-) Length   441 a.a.
NCBI ID   WP_000364846.1    Uniprot ID   Q9LB22
Organism   Streptococcus pneumoniae strain BC1     
Function   phosphorylation of ComE (predicted from homology)   
Competence regulation

Genomic Context

Location: 1248488..1259813
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  OS912_RS10965 - 1250178..1251775 (-) 1598 Protein_1221 YhgE/Pip family protein -
  OS912_RS06360 (OS912_06365) - 1251954..1252496 (+) 543 WP_001863823.1 TetR/AcrR family transcriptional regulator -
  OS912_RS06375 (OS912_06380) comE 1252739..1253491 (-) 753 WP_000866065.1 competence system response regulator transcription factor ComE Regulator
  OS912_RS06380 (OS912_06385) comD/comD2 1253488..1254813 (-) 1326 WP_000364846.1 competence system sensor histidine kinase ComD Regulator
  OS912_RS06385 (OS912_06390) comC/comC2 1254834..1254959 (-) 126 WP_000799686.1 competence-stimulating peptide ComC Regulator
  OS912_RS06395 (OS912_06400) rlmH 1255241..1255720 (-) 480 WP_000695929.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  OS912_RS06400 (OS912_06405) htrA 1255903..1257084 (+) 1182 WP_000681597.1 S1C family serine protease Regulator
  OS912_RS06405 (OS912_06410) spo0J 1257142..1257900 (+) 759 WP_000410380.1 ParB/RepB/Spo0J family partition protein Regulator
  OS912_RS06410 (OS912_06415) dnaA 1258113..1259474 (+) 1362 WP_000660615.1 chromosomal replication initiator protein DnaA -

Sequence

Protein


Download         Length: 441 a.a.        Molecular weight: 51423.95 Da        Isoelectric Point: 7.0711

>NTDB_id=761428 OS912_RS06380 WP_000364846.1 1253488..1254813(-) (comD/comD2) [Streptococcus pneumoniae strain BC1]
MDLLGFGTVIVHFLIISHSYRLICKGRINRKELYVFGAYTLLTEIVLEFSFYLLYLDKIGIERFLFPLGLYSYFRWMKQY
ERDRGLFLSLLLSLLYESTHNFLSVTFSSITGDNFVLQYHFPFFFVVTVLTYFVTLKIIYYFHLELAYFDEDYLYPFLKK
VFFALLLLHIVSFVSDMVSTIKHLNSFGSILSSIVFISLLLTFFAMNSHKVQMEKEIALKQKKFEQKHLQNYTDEIVGLY
NEIRGFRHDYAGMLVSMQMAIDSGNLQEIDRIYNEVLVKANHKLRSDKYTYFDLNNIEDSALRSLVAQSIVYARNNGVEF
TLEVKDTITKLPIELLDLVRIMSVLLNNAVEGSADSYKKQMEVAVIKMETETVIVIQNSCKMTMTPSGDLFALGFSTKGR
NRGVGLNNVKELLDKYNNIILETEMEGSTFRQIIRFKREFE

Nucleotide


Download         Length: 1326 bp        

>NTDB_id=761428 OS912_RS06380 WP_000364846.1 1253488..1254813(-) (comD/comD2) [Streptococcus pneumoniae strain BC1]
ATGGATTTACTTGGATTTGGGACAGTTATTGTTCATTTTTTAATTATTAGTCACAGTTACCGTTTAATTTGTAAAGGTCG
AATAAATAGAAAAGAATTATACGTTTTTGGTGCTTATACATTACTAACTGAAATAGTACTTGAATTTTCCTTTTATCTTC
TATATTTAGATAAAATAGGGATTGAAAGATTTTTATTTCCTTTGGGCTTATATTCCTATTTTCGATGGATGAAACAGTAT
GAGAGGGATAGAGGACTATTCCTAAGTTTACTACTATCTCTTTTATATGAGAGCACTCATAACTTTCTGTCCGTAACTTT
CTCCTCTATAACAGGAGATAATTTTGTTTTACAATATCATTTCCCATTCTTTTTCGTTGTGACGGTGTTAACCTATTTTG
TTACATTAAAAATCATTTACTATTTCCATTTGGAACTAGCCTATTTTGACGAGGACTACCTTTATCCTTTCTTGAAAAAA
GTATTTTTTGCTTTACTATTGCTACATATTGTATCTTTCGTTTCAGATATGGTAAGTACGATTAAACATTTGAATAGTTT
TGGAAGTATTTTGTCATCTATTGTCTTTATCTCTCTCCTTTTGACCTTCTTTGCAATGAATTCTCATAAAGTTCAAATGG
AGAAAGAGATTGCTTTGAAGCAGAAGAAATTTGAACAGAAACATTTACAGAATTACACAGATGAAATTGTTGGTCTGTAT
AATGAAATCCGTGGTTTTCGACATGATTATGCTGGAATGCTTGTCAGCATGCAGATGGCAATTGACAGTGGTAATTTACA
GGAAATTGACAGAATTTACAATGAAGTTTTAGTCAAAGCAAATCATAAATTGCGTTCAGATAAGTACACTTACTTTGATT
TGAACAACATAGAAGACTCAGCTTTACGAAGTTTGGTTGCTCAGTCAATTGTCTATGCTCGAAATAATGGTGTAGAGTTT
ACACTGGAAGTAAAAGATACGATTACCAAGCTTCCAATTGAACTATTGGATTTGGTTCGTATCATGAGCGTTTTATTGAA
TAATGCTGTCGAAGGATCGGCTGATAGCTATAAAAAGCAGATGGAAGTAGCAGTTATTAAGATGGAAACTGAAACAGTTA
TTGTGATTCAGAATTCATGTAAAATGACGATGACTCCTTCAGGAGATCTATTTGCCTTAGGATTCTCCACTAAGGGAAGA
AATCGCGGAGTCGGATTAAATAATGTGAAAGAACTACTAGATAAGTACAACAATATTATTTTAGAAACAGAGATGGAAGG
CAGTACATTTAGACAAATCATTAGATTTAAGAGGGAATTTGAATGA

Domains

Predicted by InterproScan.

GHKL domain (HATPase_c_5)

(334-434)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB Q9LB22

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comD/comD2 Streptococcus pneumoniae TIGR4

99.546

100

0.995
  comD/comD1 Streptococcus pneumoniae Rx1

97.279

100

0.973
  comD/comD1 Streptococcus pneumoniae D39

97.279

100

0.973
  comD/comD1 Streptococcus pneumoniae R6

97.279

100

0.973
  comD Streptococcus mitis SK321

92.063

100

0.921
  comD Streptococcus mitis NCTC 12261

86.621

100

0.866
  comD/comD1 Streptococcus gordonii str. Challis substr. CH1

49.733

84.807

0.422
  comD/comD2 Streptococcus gordonii strain NCTC7865

49.468

85.261

0.422