Detailed information    

insolico Bioinformatically predicted

Overview

Name   comC/comC2   Type   Regulator
Locus tag   OS912_RS06385 Genome accession   NZ_CP113266
Coordinates   1254834..1254959 (-) Length   41 a.a.
NCBI ID   WP_000799686.1    Uniprot ID   P60242
Organism   Streptococcus pneumoniae strain BC1     
Function   binding to ComD; induce autophosphorylation of ComD (predicted from homology)   
Competence regulation

Genomic Context

Location: 1249834..1259959
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  OS912_RS10965 - 1250178..1251775 (-) 1598 Protein_1221 YhgE/Pip family protein -
  OS912_RS06360 (OS912_06365) - 1251954..1252496 (+) 543 WP_001863823.1 TetR/AcrR family transcriptional regulator -
  OS912_RS06375 (OS912_06380) comE 1252739..1253491 (-) 753 WP_000866065.1 competence system response regulator transcription factor ComE Regulator
  OS912_RS06380 (OS912_06385) comD/comD2 1253488..1254813 (-) 1326 WP_000364846.1 competence system sensor histidine kinase ComD Regulator
  OS912_RS06385 (OS912_06390) comC/comC2 1254834..1254959 (-) 126 WP_000799686.1 competence-stimulating peptide ComC Regulator
  OS912_RS06395 (OS912_06400) rlmH 1255241..1255720 (-) 480 WP_000695929.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  OS912_RS06400 (OS912_06405) htrA 1255903..1257084 (+) 1182 WP_000681597.1 S1C family serine protease Regulator
  OS912_RS06405 (OS912_06410) spo0J 1257142..1257900 (+) 759 WP_000410380.1 ParB/RepB/Spo0J family partition protein Regulator
  OS912_RS06410 (OS912_06415) dnaA 1258113..1259474 (+) 1362 WP_000660615.1 chromosomal replication initiator protein DnaA -

Sequence

Protein


Download         Length: 41 a.a.        Molecular weight: 4907.00 Da        Isoelectric Point: 11.0006

>NTDB_id=761429 OS912_RS06385 WP_000799686.1 1254834..1254959(-) (comC/comC2) [Streptococcus pneumoniae strain BC1]
MKNTVKLEQFVALKEKDLQKIKGGEMRISRIILDFLFLRKK

Nucleotide


Download         Length: 126 bp        

>NTDB_id=761429 OS912_RS06385 WP_000799686.1 1254834..1254959(-) (comC/comC2) [Streptococcus pneumoniae strain BC1]
ATGAAAAACACAGTTAAATTGGAACAGTTTGTAGCTTTGAAGGAAAAAGACTTACAAAAGATTAAAGGTGGGGAGATGAG
GATTTCAAGAATCATCCTTGATTTTCTTTTCCTACGAAAAAAGTAA

Domains

Predicted by InterproScan.

COMC family (ComC)

(1-29)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  PDB 6CJ8
  PDB 6COO
  PDB 6COP
  PDB 6COQ
  PDB 6COR
  PDB 6COS
  PDB 6COW
  PDB 6OBW
  PDB 6OC2
  PDB 6OC4
  PDB 6OLD
  PDB 6V1N

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comC/comC2 Streptococcus pneumoniae A66

100

100

1
  comC/comC2 Streptococcus pneumoniae TIGR4

100

100

1
  comC/comC1 Streptococcus pneumoniae R6

80.488

100

0.805
  comC/comC1 Streptococcus pneumoniae G54

80.488

100

0.805
  comC/comC1 Streptococcus pneumoniae D39

80.488

100

0.805
  comC/comC1 Streptococcus pneumoniae Rx1

80.488

100

0.805
  comC Streptococcus mitis SK321

75.61

100

0.756
  comC Streptococcus mitis NCTC 12261

57.5

97.561

0.561