Detailed information NTG0075392

Bioinformatically predicted

Overview

• Name: comE
• Type: Regulator
• Locus tag: UKS_RS09650
• Genome accession: NZ_AP021887
• Coordinates: 1938382..1939134 (-)
• Length: 250 a.a.
• NCBI ID: WP_000866062.1
• Uniprot ID: A0A6H3SL01
• Organism: Streptococcus sp. 116-D4
• Function: activate transcription of early competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1933382..1944134

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
UKS_RS09630 (UKS_18690)	-	1934827..1937469 (-)	2643	WP_156012993.1	YhgE/Pip domain-containing protein	-
UKS_RS09635 (UKS_18700)	-	1937597..1938139 (+)	543	WP_156012995.1	TetR-like C-terminal domain-containing protein	-
UKS_RS09650 (UKS_18710)	comE	1938382..1939134 (-)	753	WP_000866062.1	competence system response regulator transcription factor ComE	Regulator
UKS_RS09655 (UKS_18720)	comD/comD1	1939131..1940456 (-)	1326	WP_156012996.1	competence system sensor histidine kinase ComD	Regulator
UKS_RS09660 (UKS_18730)	comC	1940468..1940599 (-)	132	WP_156012998.1	competence-stimulating peptide ComC	Regulator
UKS_RS09670 (UKS_18740)	rlmH	1940882..1941361 (-)	480	WP_049496558.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
UKS_RS09675 (UKS_18750)	htrA	1941549..1942730 (+)	1182	WP_156013000.1	S1C family serine protease	Regulator
UKS_RS09680 (UKS_18760)	spo0J	1942788..1943546 (+)	759	WP_156013002.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 250 a.a.
• Molecular weight: 29940.28 Da
• Isoelectric Point: 6.5073

>NTDB_id=75392 UKS_RS09650 WP_000866062.1 1938382..1939134(-) (comE) [Streptococcus sp. 116-D4]
MKVLILEDVIEHQVRLERILDEISKESNIPISYKTTGKVREFEEYIENDEVNQLYFLDIDIHGIEKKGFEVAQLIRHYNP
YAIIVFITSRSEFATLTYKYQVSALDFVDKDINDELFKKRIEQNIFYTKSMLLENEDVVDYFDYNYKGNDLKIPYHDILY
IETTGVSHKLRIIGKNFAKEFYGTMTDIQEKDKHTQRFYSPHKSFLVNIGNIREIDRKNLEIVFYEDHRCPISRLKIRKL
KDILEKKSQK

Nucleotide

• Length: 753 bp

>NTDB_id=75392 UKS_RS09650 WP_000866062.1 1938382..1939134(-) (comE) [Streptococcus sp. 116-D4]
ATGAAAGTTTTAATTTTAGAGGATGTTATTGAACATCAAGTGAGACTAGAGAGAATATTGGATGAAATTTCGAAAGAATC
GAATATTCCAATATCATACAAGACAACGGGAAAAGTCCGTGAATTTGAAGAATATATTGAAAATGATGAAGTAAATCAGC
TTTATTTCCTAGATATCGATATTCATGGAATTGAGAAAAAAGGATTTGAAGTGGCTCAACTCATTCGTCATTACAATCCT
TACGCAATTATCGTCTTTATCACCAGTCGATCAGAGTTTGCGACTCTCACCTATAAATACCAGGTATCAGCCCTAGATTT
TGTTGATAAGGATATCAATGATGAGTTATTTAAGAAGCGAATTGAGCAAAATATCTTCTACACGAAGAGTATGTTACTTG
AAAATGAAGATGTGGTAGATTATTTTGACTACAATTATAAGGGAAATGATTTAAAAATTCCTTATCATGACATTCTGTAT
ATTGAAACGACAGGAGTTTCTCATAAATTGCGCATTATTGGTAAGAATTTTGCAAAAGAGTTTTATGGTACCATGACAGA
TATTCAAGAAAAGGACAAACATACTCAGCGATTTTATTCCCCTCATAAGTCATTTTTGGTAAATATAGGCAATATCAGAG
AAATTGATCGAAAAAACTTAGAAATTGTTTTCTATGAAGATCATCGCTGTCCTATTTCAAGGTTAAAAATTAGAAAATTA
AAAGATATTCTAGAGAAAAAATCTCAAAAGTAA

Domains

Predicted by InterproScan.

• LytTr DNA-binding domain (LytTR) (151-244)

• Response regulator receiver domain (Response_reg) (3-121)

3D structure

• AlphaFold DB: A0A6H3SL01

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE	Streptococcus pneumoniae Rx1	99.6	100	0.996
comE	Streptococcus pneumoniae D39	99.6	100	0.996
comE	Streptococcus pneumoniae R6	99.6	100	0.996
comE	Streptococcus pneumoniae TIGR4	99.6	100	0.996
comE	Streptococcus mitis SK321	99.6	100	0.996
comE	Streptococcus mitis NCTC 12261	98.8	100	0.988
comE	Streptococcus infantis strain Atu-4	91.6	100	0.916
comE/comE2	Streptococcus gordonii strain NCTC7865	62.8	100	0.628
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	62.8	100	0.628
comE/blpR	Streptococcus mutans UA159	41.296	98.8	0.408