Detailed information NTG0075395

Bioinformatically predicted

Overview

• Name: htrA
• Type: Regulator
• Locus tag: UKS_RS09675
• Genome accession: NZ_AP021887
• Coordinates: 1941549..1942730 (+)
• Length: 393 a.a.
• NCBI ID: WP_156013000.1
• Uniprot ID: A0A6H3SF62
• Organism: Streptococcus sp. 116-D4
• Function: repress competence development (predicted from homology) Competence regulation

Genomic Context

Location: 1936549..1947730

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
UKS_RS09635 (UKS_18700)	-	1937597..1938139 (+)	543	WP_156012995.1	TetR-like C-terminal domain-containing protein	-
UKS_RS09650 (UKS_18710)	comE	1938382..1939134 (-)	753	WP_000866062.1	competence system response regulator transcription factor ComE	Regulator
UKS_RS09655 (UKS_18720)	comD/comD1	1939131..1940456 (-)	1326	WP_156012996.1	competence system sensor histidine kinase ComD	Regulator
UKS_RS09660 (UKS_18730)	comC	1940468..1940599 (-)	132	WP_156012998.1	competence-stimulating peptide ComC	Regulator
UKS_RS09670 (UKS_18740)	rlmH	1940882..1941361 (-)	480	WP_049496558.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
UKS_RS09675 (UKS_18750)	htrA	1941549..1942730 (+)	1182	WP_156013000.1	S1C family serine protease	Regulator
UKS_RS09680 (UKS_18760)	spo0J	1942788..1943546 (+)	759	WP_156013002.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 393 a.a.
• Molecular weight: 41684.50 Da
• Isoelectric Point: 6.1486

>NTDB_id=75395 UKS_RS09675 WP_156013000.1 1941549..1942730(+) (htrA) [Streptococcus sp. 116-D4]
MKHLKTFYKKWFQLLVVIVISFISGALGSFSITQLTQKSGASSSNNNSTITQTAYKNENSTTQAVNKVKDAVVSVITYSS
NRQNSVFGNDDTDTDSQQISSEGSGVIYKKNDKEAYIVTNNHVINGASKVDIRLSDGTKVPGEIVGADTFSDIAVVKISS
EKVTTVAEFGDSSKLTVGETAIAIGSPLGSEYANTVTQGIVSSLNRNVSLKSEDGQAISTKAIQTDTAINPGNSGGPLIN
IQGQVIGITSSKIATNGGTSVEGLGFAIPANDAINIIEQLEKNGKVTRPALGIQMVNLSNINTSDIRRLNIPSNVTSGVV
VRSVQSNMPASGHLEKYDVITKVDDKEIASSTDLQSALYNHSIGDTIKITYYRNGKEETTSIKLDKSSGDLES

Nucleotide

• Length: 1182 bp

>NTDB_id=75395 UKS_RS09675 WP_156013000.1 1941549..1942730(+) (htrA) [Streptococcus sp. 116-D4]
ATGAAACATCTAAAAACATTTTACAAAAAATGGTTTCAATTACTAGTCGTTATCGTCATTAGCTTTATTAGCGGTGCCTT
GGGTAGTTTTTCAATAACTCAACTAACTCAAAAAAGTGGTGCAAGTAGCTCTAACAACAATAGTACTATTACACAAACTG
CCTATAAAAACGAAAATTCAACAACACAGGCTGTTAACAAAGTAAAAGATGCTGTTGTTTCTGTTATTACTTATTCGTCA
AACAGACAAAATAGCGTATTTGGTAATGATGATACTGACACTGATTCTCAGCAAATCTCTAGTGAAGGATCTGGGGTTAT
TTATAAAAAGAATGATAAAGAAGCTTATATTGTCACCAACAATCACGTTATAAATGGCGCCAGCAAAGTAGATATTCGTT
TGTCAGATGGAACTAAAGTACCCGGAGAAATTGTCGGAGCGGACACTTTCTCTGATATTGCTGTCGTCAAAATCTCTTCA
GAAAAAGTGACAACAGTAGCTGAGTTTGGTGATTCTAGCAAGTTAACCGTAGGAGAAACTGCTATTGCCATCGGTAGCCC
GTTAGGTTCTGAATATGCTAATACTGTCACTCAAGGTATCGTATCTAGTCTCAATCGAAATGTATCTTTAAAATCTGAAG
ATGGGCAAGCCATTTCTACAAAAGCCATCCAAACTGATACTGCTATTAACCCAGGTAACTCTGGTGGCCCACTGATCAAT
ATTCAAGGACAGGTTATCGGAATTACCTCAAGTAAAATTGCCACAAATGGAGGAACATCTGTAGAAGGTCTTGGTTTTGC
AATCCCTGCCAATGATGCTATCAATATTATTGAACAGTTAGAAAAGAACGGAAAAGTGACTCGTCCAGCATTGGGAATTC
AAATGGTCAATCTCTCAAATATTAATACAAGTGATATTAGAAGACTGAATATTCCAAGCAATGTAACATCTGGTGTAGTT
GTTCGTTCTGTGCAGAGTAATATGCCTGCCAGTGGTCACCTTGAAAAATACGATGTTATTACAAAAGTAGATGACAAAGA
GATTGCTTCATCAACAGACTTACAAAGTGCTCTTTACAATCATTCTATCGGAGATACCATTAAGATAACTTACTATCGTA
ACGGTAAAGAAGAAACTACATCTATTAAACTTGACAAGAGTTCAGGTGATTTAGAATCTTAA

Domains

Predicted by InterproScan.

• PDZ domain (PDZ_2) (289-384)

• Trypsin-like peptidase domain (Trypsin_2) (103-248)

3D structure

• AlphaFold DB: A0A6H3SF62

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
htrA	Streptococcus mitis NCTC 12261	97.964	100	0.98
htrA	Streptococcus pneumoniae Rx1	96.947	100	0.969
htrA	Streptococcus pneumoniae D39	96.947	100	0.969
htrA	Streptococcus pneumoniae R6	96.947	100	0.969
htrA	Streptococcus pneumoniae TIGR4	96.947	100	0.969
htrA	Streptococcus gordonii str. Challis substr. CH1	66.414	100	0.669
htrA	Streptococcus mutans UA159	54.569	100	0.547