Detailed information    

insolico Bioinformatically predicted

Overview

Name   comD/comD1   Type   Regulator
Locus tag   UKS_RS09655 Genome accession   NZ_AP021887
Coordinates   1939131..1940456 (-) Length   441 a.a.
NCBI ID   WP_156012996.1    Uniprot ID   A0A6H3S834
Organism   Streptococcus sp. 116-D4     
Function   phosphorylation of ComE (predicted from homology)   
Competence regulation

Genomic Context

Location: 1934131..1945456
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  UKS_RS09630 (UKS_18690) - 1934827..1937469 (-) 2643 WP_156012993.1 YhgE/Pip domain-containing protein -
  UKS_RS09635 (UKS_18700) - 1937597..1938139 (+) 543 WP_156012995.1 TetR-like C-terminal domain-containing protein -
  UKS_RS09650 (UKS_18710) comE 1938382..1939134 (-) 753 WP_000866062.1 competence system response regulator transcription factor ComE Regulator
  UKS_RS09655 (UKS_18720) comD/comD1 1939131..1940456 (-) 1326 WP_156012996.1 competence system sensor histidine kinase ComD Regulator
  UKS_RS09660 (UKS_18730) comC 1940468..1940599 (-) 132 WP_156012998.1 competence-stimulating peptide ComC Regulator
  UKS_RS09670 (UKS_18740) rlmH 1940882..1941361 (-) 480 WP_049496558.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  UKS_RS09675 (UKS_18750) htrA 1941549..1942730 (+) 1182 WP_156013000.1 S1C family serine protease Regulator
  UKS_RS09680 (UKS_18760) spo0J 1942788..1943546 (+) 759 WP_156013002.1 ParB/RepB/Spo0J family partition protein Regulator

Sequence

Protein


Download         Length: 441 a.a.        Molecular weight: 51216.59 Da        Isoelectric Point: 6.5764

>NTDB_id=75393 UKS_RS09655 WP_156012996.1 1939131..1940456(-) (comD/comD1) [Streptococcus sp. 116-D4]
MDFFSVVDFILYFLIISHSYHLICKGQINRKELCFFGVYTLLVGTILDLPFYLLYLDGLGIATFLFPLGLYSYFRWKKQY
ERDRGLFLSLLLALLYESTHNFLSVTFSSITGDNFVLQYHDPFFFVVTVLTYVVIVTIIRYFHLELAYFDKDYLYPFLKK
IFFALLLLHIVSFVSDMVSTVKHLNSFGSILSSIVFISLLLTFFAMNSHKEQMEKEIALKQKKFEQRHLQNYTDEIVGLY
NEIRGFRHDYAGMLVSMQMAIDSGDLQEIDRVYNEVLVKANHKLRSDKYTYFDLNNIEDSALRSLVAQSIVYARNNGVEF
TLEVKDTITNLPIELLDLVRIMSVLLNNAVEGSADSYKKQMEVAVIKMETETVIVIQNSCKMTMTPSGDLFTLGFSTKGR
NRGVGLNNVKELLNKYNNIILETEMEGSTFRQIIRFKREFE

Nucleotide


Download         Length: 1326 bp        

>NTDB_id=75393 UKS_RS09655 WP_156012996.1 1939131..1940456(-) (comD/comD1) [Streptococcus sp. 116-D4]
ATGGATTTTTTTTCAGTAGTAGATTTTATATTATATTTTTTAATTATTAGTCACAGTTACCATTTAATTTGTAAAGGTCA
AATAAATAGAAAAGAATTATGCTTTTTTGGTGTTTATACATTACTAGTAGGAACAATACTTGATCTTCCTTTTTATCTTC
TATATTTAGATGGGTTAGGGATTGCAACATTTTTATTTCCTTTGGGCTTATATTCCTATTTTCGATGGAAGAAACAGTAT
GAGAGGGATAGAGGACTATTCCTAAGTTTACTACTAGCTCTTTTATATGAGAGCACTCATAACTTTCTGTCCGTAACTTT
CTCCTCTATAACAGGAGACAATTTTGTTTTACAATACCATGACCCATTCTTTTTCGTTGTAACGGTGTTGACCTATGTCG
TTATCGTTACAATCATTCGTTATTTCCATTTGGAACTAGCCTATTTTGACAAAGACTACCTCTATCCTTTCTTGAAAAAA
ATATTTTTTGCTTTACTATTGCTCCATATTGTATCTTTCGTTTCTGATATGGTAAGTACGGTTAAACATTTGAATAGTTT
TGGAAGTATTTTATCATCTATCGTCTTTATTTCTCTCCTTTTGACCTTCTTTGCAATGAATTCGCATAAAGAACAAATGG
AGAAAGAGATTGCGTTGAAGCAGAAGAAATTTGAACAGAGACATTTACAGAATTATACAGACGAAATTGTTGGCTTGTAT
AATGAAATCCGTGGTTTTCGACATGACTATGCTGGAATGCTTGTCAGCATGCAGATGGCAATTGACAGTGGTGATTTACA
GGAAATTGACAGAGTTTACAATGAAGTTTTGGTCAAAGCTAATCATAAACTGCGTTCAGATAAGTACACTTACTTTGATT
TGAACAACATAGAAGATTCAGCTTTAAGAAGTTTGGTTGCTCAGTCCATTGTCTATGCTCGAAATAATGGTGTAGAGTTT
ACACTTGAAGTAAAAGATACGATTACCAATCTACCAATTGAACTATTGGATTTAGTTCGTATTATGAGTGTTTTATTGAA
CAATGCTGTCGAAGGATCGGCTGATAGCTATAAAAAGCAGATGGAAGTAGCAGTTATTAAGATGGAAACTGAAACAGTTA
TTGTGATTCAGAATTCATGTAAAATGACGATGACTCCTTCAGGAGATCTATTTACTTTAGGATTCTCAACTAAGGGAAGA
AATCGCGGAGTAGGCTTAAATAATGTGAAAGAACTACTAAATAAGTACAACAATATTATTTTAGAAACAGAGATGGAAGG
CAGTACATTTAGACAAATTATTAGATTTAAGAGGGAATTTGAATGA

Domains

Predicted by InterproScan.

GHKL domain (HATPase_c_5)

(334-434)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A6H3S834

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comD/comD1 Streptococcus pneumoniae Rx1

90.93

100

0.909
  comD/comD1 Streptococcus pneumoniae D39

90.93

100

0.909
  comD/comD1 Streptococcus pneumoniae R6

90.93

100

0.909
  comD/comD2 Streptococcus pneumoniae TIGR4

90.249

100

0.902
  comD Streptococcus mitis SK321

89.342

100

0.893
  comD Streptococcus mitis NCTC 12261

87.302

100

0.873
  comD/comD1 Streptococcus gordonii str. Challis substr. CH1

49.465

84.807

0.419
  comD/comD2 Streptococcus gordonii strain NCTC7865

48.936

85.261

0.417

Multiple sequence alignment