Detailed information NTG0717697

Bioinformatically predicted

Overview

• Name: comE/blpR
• Type: Regulator
• Locus tag: MGCS35957_RS02710
• Genome accession: NZ_CP117288
• Coordinates: 514607..515356 (+)
• Length: 249 a.a.
• NCBI ID: WP_030126108.1
• Uniprot ID: A0A223M029
• Organism: Streptococcus dysgalactiae subsp. equisimilis strain MGCS35957
• Function: activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 509607..520356

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
MGCS35957_RS02690 (MGCS35957_01102)	-	509833..510150 (+)	318	WP_002994587.1	hypothetical protein	-
MGCS35957_RS02695 (MGCS35957_01104)	-	510333..511354 (+)	1022	Protein_487	IS3 family transposase	-
MGCS35957_RS02700 (MGCS35957_01106)	-	511568..512986 (+)	1419	WP_231873805.1	IS1182 family transposase	-
MGCS35957_RS02710 (MGCS35957_01110)	comE/blpR	514607..515356 (+)	750	WP_030126108.1	response regulator transcription factor	Regulator
MGCS35957_RS02720 (MGCS35957_01114)	-	515698..516831 (-)	1134	WP_275902597.1	ISAs1-like element IS1548 family transposase	-
MGCS35957_RS02725 (MGCS35957_01116)	comD/blpH	517061..518017 (+)	957	WP_046166194.1	GHKL domain-containing protein	Regulator
MGCS35957_RS02730 (MGCS35957_01118)	-	518165..518290 (-)	126	WP_011017462.1	ComC/BlpC family leader-containing pheromone/bacteriocin	-
MGCS35957_RS02735 (MGCS35957_01122)	-	518367..519731 (-)	1365	WP_084916305.1	bacteriocin secretion accessory protein	-

Sequence

Protein

• Length: 249 a.a.
• Molecular weight: 29141.44 Da
• Isoelectric Point: 5.8302

>NTDB_id=717697 MGCS35957_RS02710 WP_030126108.1 514607..515356(+) (comE/blpR) [Streptococcus dysgalactiae subsp. equisimilis strain MGCS35957]
MNIFVLEDDFLHQTRIEKIIYKILTDNKLEVNHLEVYGKPNQLLEDISERGRHQLFFLDIDIKGEDKKGMEIAVEIRNKD
PHAVIVFVTTHSEFMPVSFQYQVSALDFIDKELPEELFSHRIEKAITYVQDNQGKTLAEDSFVFTNVKSQIQVSFSDLLY
IETSLIPHKLILYSTKQRVEFYGQLSEIVEQDDRLFQCHRSFVVNPYNISSIDRSERLVYLKGGLSCIVSRLKIRSLIKV
VEELHTKEK

Nucleotide

• Length: 750 bp

>NTDB_id=717697 MGCS35957_RS02710 WP_030126108.1 514607..515356(+) (comE/blpR) [Streptococcus dysgalactiae subsp. equisimilis strain MGCS35957]
ATGAATATTTTTGTCTTAGAGGACGATTTTTTACATCAAACCAGAATTGAAAAAATTATTTATAAGATTTTGACTGATAA
TAAGTTGGAGGTTAACCACTTGGAAGTTTATGGTAAACCCAATCAGCTGCTTGAAGATATATCAGAGAGAGGAAGACATC
AGCTTTTTTTTCTTGACATTGACATTAAGGGAGAAGATAAAAAAGGAATGGAAATTGCTGTGGAGATTAGAAATAAAGAT
CCGCACGCAGTGATAGTTTTTGTGACCACACATTCAGAATTTATGCCGGTATCTTTTCAATACCAGGTTTCAGCTTTAGA
CTTTATTGACAAAGAGTTGCCAGAGGAGTTATTTAGTCATCGCATTGAAAAAGCTATAACTTATGTACAAGATAACCAAG
GAAAAACGTTAGCGGAGGATTCATTTGTTTTTACTAATGTAAAGTCCCAGATACAAGTCTCCTTTTCAGATTTGCTGTAT
ATTGAAACCTCACTAATTCCCCATAAACTCATTCTCTATTCTACTAAACAAAGAGTAGAATTTTATGGTCAATTATCAGA
AATTGTTGAGCAAGATGATCGATTATTTCAATGTCATCGTTCCTTTGTTGTCAATCCCTATAATATATCATCAATAGATA
GATCCGAACGGTTAGTTTATTTAAAGGGGGGATTATCTTGTATTGTTTCGAGATTGAAAATACGATCATTAATAAAAGTA
GTAGAAGAGTTGCACACTAAGGAGAAATAG

Domains

Predicted by InterProScan.

• LytTr DNA-binding domain (LytTR) (150-239)

• Response regulator receiver domain (Response_reg) (3-119)

3D structure

• AlphaFold DB: A0A223M029

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/blpR	Streptococcus mutans UA159	54.098	97.992	0.53
comE/comE2	Streptococcus gordonii strain NCTC7865	40.476	100	0.41
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	40.476	100	0.41
comE/comE1	Streptococcus equinus JB1	42.437	95.582	0.406
comE/comE2	Streptococcus equinus JB1	40.574	97.992	0.398
comE	Streptococcus mitis NCTC 12261	38.4	100	0.386
comE	Streptococcus mitis SK321	38.4	100	0.386
comE	Streptococcus pneumoniae TIGR4	38	100	0.382
comE	Streptococcus pneumoniae Rx1	38	100	0.382
comE	Streptococcus pneumoniae D39	38	100	0.382
comE	Streptococcus pneumoniae R6	38	100	0.382
comE	Streptococcus infantis strain Atu-4	37.903	99.598	0.378