Detailed information NTG0070923

Bioinformatically predicted

Overview

• Name: comE/blpR
• Type: Regulator
• Locus tag: H7680_RS02570
• Genome accession: NZ_AP023394
• Coordinates: 488037..488786 (+)
• Length: 249 a.a.
• NCBI ID: WP_046159788.1
• Uniprot ID: -
• Organism: Streptococcus dysgalactiae subsp. equisimilis strain 159
• Function: activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 483037..493786

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
H7680_RS02540 (SDSE159_04560)	-	484803..485030 (+)	228	WP_003054378.1	bacteriocin-type signal sequence	-
H7680_RS02545 (SDSE159_04570)	-	485079..485396 (+)	318	WP_002994587.1	hypothetical protein	-
H7680_RS02550 (SDSE159_04580)	-	485780..486043 (+)	264	WP_255306607.1	Blp family class II bacteriocin	-
H7680_RS02555 (SDSE159_04590)	-	486057..486242 (+)	186	WP_003054392.1	hypothetical protein	-
H7680_RS02560	-	486496..486666 (+)	171	WP_014612080.1	hypothetical protein	-
H7680_RS02565	-	486685..487790 (-)	1106	Protein_451	IS3 family transposase	-
H7680_RS02570 (SDSE159_04640)	comE/blpR	488037..488786 (+)	750	WP_046159788.1	response regulator transcription factor	Regulator
H7680_RS02575 (SDSE159_04650)	-	488787..490121 (+)	1335	WP_138127997.1	GHKL domain-containing protein	-
H7680_RS02580 (SDSE159_04660)	-	490182..490307 (-)	126	WP_011017462.1	ComC/BlpC family leader-containing pheromone/bacteriocin	-
H7680_RS02585 (SDSE159_04670)	-	490398..491762 (-)	1365	WP_012766651.1	bacteriocin secretion accessory protein	-

Sequence

Protein

• Length: 249 a.a.
• Molecular weight: 29211.53 Da
• Isoelectric Point: 5.6520

>NTDB_id=70923 H7680_RS02570 WP_046159788.1 488037..488786(+) (comE/blpR) [Streptococcus dysgalactiae subsp. equisimilis strain 159]
MNIFILEDDFLQQSRIEKIIYKILTDNKWEINHLGVYGKPNQLLEDISERGRHQLFFLDIDIKGEDKKGMEIAVEIRNRD
PYAVIVFVTTHSEFMPVSFQYQVSALDFIDKELPEELFSHRIEKAITYVQDNQGKTLAEDSFVFTNVKSQIQVPFSDLLY
IETSLIPHKLILYSTKQRVEFYGQLSEIVEQDDRLFQCHRSFVVNPYNISSIDRSERLVYLKGGLSCIVSRLKIRSLIKV
VEELHTKEK

Nucleotide

• Length: 750 bp

>NTDB_id=70923 H7680_RS02570 WP_046159788.1 488037..488786(+) (comE/blpR) [Streptococcus dysgalactiae subsp. equisimilis strain 159]
ATGAATATTTTTATTTTGGAAGATGATTTTTTACAACAAAGCAGAATTGAAAAAATTATTTATAAGATTTTGACTGATAA
TAAGTGGGAGATTAACCACTTGGGAGTTTATGGTAAACCTAATCAGCTGCTTGAAGATATATCAGAGAGAGGAAGACATC
AGCTTTTTTTTCTTGACATTGACATTAAGGGAGAAGATAAAAAAGGAATGGAGATTGCTGTGGAGATTAGAAATAGAGAT
CCGTACGCAGTGATAGTTTTTGTGACCACACATTCAGAATTTATGCCGGTGTCTTTTCAATACCAGGTTTCAGCTTTAGA
CTTTATTGACAAAGAGTTGCCAGAGGAGTTATTTAGTCATCGCATTGAAAAAGCTATAACTTATGTACAAGATAACCAAG
GAAAAACGTTAGCGGAGGATTCATTTGTTTTTACTAATGTAAAGTCCCAGATACAAGTCCCCTTTTCAGATTTGCTGTAT
ATTGAAACCTCACTAATTCCCCATAAACTCATTCTCTATTCTACTAAACAAAGAGTAGAATTTTATGGCCAATTATCAGA
AATTGTTGAGCAAGATGATCGATTATTTCAATGTCATCGTTCCTTTGTTGTTAATCCCTATAATATATCATCAATAGATA
GATCCGAACGGTTAGTTTATTTAAAGGGGGGATTATCTTGTATTGTTTCGAGATTGAAAATACGATCATTAATAAAAGTA
GTAGAAGAGTTGCACACTAAGGAGAAATAG

Domains

Predicted by InterProScan.

• LytTr DNA-binding domain (LytTR) (150-239)

• Response regulator receiver domain (Response_reg) (3-119)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/blpR	Streptococcus mutans UA159	54.918	97.992	0.538
comE/comE1	Streptococcus equinus JB1	42.857	95.582	0.41
comE/comE2	Streptococcus gordonii strain NCTC7865	40.476	100	0.41
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	40.476	100	0.41
comE/comE2	Streptococcus equinus JB1	40.984	97.992	0.402
comE	Streptococcus mitis NCTC 12261	39.6	100	0.398
comE	Streptococcus mitis SK321	39.6	100	0.398
comE	Streptococcus pneumoniae Rx1	39.2	100	0.394
comE	Streptococcus pneumoniae D39	39.2	100	0.394
comE	Streptococcus pneumoniae R6	39.2	100	0.394
comE	Streptococcus pneumoniae TIGR4	39.2	100	0.394
comE	Streptococcus infantis strain Atu-4	39.113	99.598	0.39
agrA	Staphylococcus aureus N315	36.585	98.795	0.361