Detailed information NTG0067292

Bioinformatically predicted

Overview

• Name: comE
• Type: Regulator
• Locus tag: SITYG_RS10220
• Genome accession: NZ_AP014880
• Coordinates: 2001645..2002394 (-)
• Length: 249 a.a.
• NCBI ID: WP_096363305.1
• Uniprot ID: A0AAD1C9L0
• Organism: Streptococcus intermedius strain TYG1620
• Function: activate transcription of early competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1996645..2007394

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SITYG_RS10200 (SITYG_20130)	-	1997049..1998671 (+)	1623	WP_003077196.1	ATP-binding cassette domain-containing protein	-
SITYG_RS10205 (SITYG_20140)	-	1998745..2001321 (+)	2577	WP_096363304.1	YfhO family protein	-
SITYG_RS10220 (SITYG_20150)	comE	2001645..2002394 (-)	750	WP_096363305.1	competence system response regulator transcription factor ComE	Regulator
SITYG_RS10225 (SITYG_20160)	comD/comD1	2002394..2003719 (-)	1326	WP_221761483.1	GHKL domain-containing protein	Regulator
SITYG_RS10230 (SITYG_20170)	-	2003736..2003882 (-)	147	WP_003075491.1	bacteriocin	-
SITYG_RS10240 (SITYG_20180)	rlmH	2004159..2004638 (-)	480	WP_096363307.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
SITYG_RS10245 (SITYG_20190)	htrA	2004842..2006032 (+)	1191	WP_020999302.1	S1C family serine protease	Regulator
SITYG_RS10250 (SITYG_20200)	spo0J	2006087..2006854 (+)	768	WP_096363308.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 249 a.a.
• Molecular weight: 29173.76 Da
• Isoelectric Point: 8.0443

>NTDB_id=67292 SITYG_RS10220 WP_096363305.1 2001645..2002394(-) (comE) [Streptococcus intermedius strain TYG1620]
MKVLVLEDEISHQVRMETTLAEIAKEMGISIKVKVTGKIREFKEYIENDEVNQLYFLDIDIKGEETKGLEIAKFIRHHNP
YAIIVFVTTKSEFATMTFKYKVSALDFVDKNLNDVAFKKHIKDSIEYTKATLIENKDMVDYFEYSFRGGEVRMPFNDILY
IETTGSSHKLRIVGKNFLKEFYGTIADIQEKDKETQRFFSPHKSYLVNIGNIKSYDKKMKEIIFYEDHRCPITRMKIGKL
KTILEESKG

Nucleotide

• Length: 750 bp

>NTDB_id=67292 SITYG_RS10220 WP_096363305.1 2001645..2002394(-) (comE) [Streptococcus intermedius strain TYG1620]
ATGAAAGTATTAGTATTAGAAGATGAAATTTCACATCAAGTAAGAATGGAAACAACTTTGGCAGAGATTGCAAAAGAGAT
GGGAATTTCTATCAAAGTTAAAGTAACTGGAAAAATAAGAGAATTTAAAGAATATATTGAGAATGATGAAGTAAATCAAT
TATACTTTTTAGATATTGATATTAAAGGGGAAGAGACAAAAGGTTTAGAAATAGCAAAATTTATACGTCATCATAATCCG
TATGCTATTATTGTTTTTGTTACAACGAAATCAGAATTTGCTACTATGACTTTTAAATATAAAGTTTCTGCACTAGATTT
TGTTGATAAAAATTTGAATGATGTTGCTTTTAAAAAACATATAAAAGATAGCATTGAGTATACAAAAGCAACGTTGATTG
AAAATAAAGATATGGTTGATTATTTTGAATATAGTTTTCGTGGTGGAGAAGTTAGAATGCCATTTAATGATATTTTATAT
ATTGAAACGACAGGTTCTTCTCATAAATTAAGAATTGTAGGTAAAAACTTTCTTAAAGAATTTTATGGTACTATTGCAGA
TATTCAAGAAAAAGACAAGGAGACACAGCGTTTCTTTTCACCTCATAAATCTTATTTAGTTAATATTGGAAATATTAAGA
GTTATGACAAAAAAATGAAAGAAATTATTTTTTATGAAGATCACCGTTGCCCAATTACTCGAATGAAAATTGGAAAGTTG
AAAACTATTTTAGAGGAGTCAAAAGGATGA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (3-121)

• LytTr DNA-binding domain (LytTR) (152-244)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE	Streptococcus mitis NCTC 12261	71.02	98.394	0.699
comE/comE2	Streptococcus gordonii strain NCTC7865	70.902	97.992	0.695
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	70.902	97.992	0.695
comE	Streptococcus infantis strain Atu-4	70.612	98.394	0.695
comE	Streptococcus mitis SK321	70.204	98.394	0.691
comE	Streptococcus pneumoniae Rx1	69.796	98.394	0.687
comE	Streptococcus pneumoniae D39	69.796	98.394	0.687
comE	Streptococcus pneumoniae R6	69.796	98.394	0.687
comE	Streptococcus pneumoniae TIGR4	69.796	98.394	0.687
comE/blpR	Streptococcus mutans UA159	40.161	100	0.402
comE/comE2	Streptococcus equinus JB1	35.019	100	0.361