Detailed information    

insolico Bioinformatically predicted

Overview

Name   comE/blpR   Type   Regulator
Locus tag   SRT_RS01400 Genome accession   NZ_AP014612
Coordinates   269918..270670 (+) Length   250 a.a.
NCBI ID   WP_128832792.1    Uniprot ID   A0A1L7LH43
Organism   Streptococcus troglodytae strain TKU 31     
Function   activate transcription of early competence genes; regulation of comX expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 264918..275670
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SRT_RS01380 (SRT_02600) dnaI 265833..266732 (+) 900 WP_128832788.1 primosomal protein DnaI -
  SRT_RS01385 (SRT_02610) der 266745..268055 (+) 1311 WP_128832789.1 ribosome biogenesis GTPase Der -
  SRT_RS01390 (SRT_02620) - 268135..268761 (+) 627 WP_128832790.1 ribonuclease P -
  SRT_RS01395 (SRT_02630) - 268808..269446 (+) 639 WP_128832791.1 VTT domain-containing protein -
  SRT_RS01400 (SRT_02640) comE/blpR 269918..270670 (+) 753 WP_128832792.1 response regulator transcription factor Regulator
  SRT_RS01405 (SRT_02650) comD/blpH 270667..271998 (+) 1332 WP_128832793.1 sensor histidine kinase Regulator
  SRT_RS01410 (SRT_02660) - 272140..272279 (-) 140 Protein_246 ComC/BlpC family leader-containing pheromone/bacteriocin -
  SRT_RS01415 (SRT_02670) - 272546..272770 (+) 225 WP_128832794.1 Blp family class II bacteriocin -
  SRT_RS01425 (SRT_02680) - 273102..273506 (+) 405 WP_128832795.1 hypothetical protein -
  SRT_RS10540 (SRT_02690) - 273629..273840 (-) 212 Protein_249 IS3 family transposase -
  SRT_RS10390 - 274278..274442 (+) 165 WP_128832796.1 hypothetical protein -
  SRT_RS01440 (SRT_02700) - 274849..275061 (+) 213 WP_128832797.1 Blp family class II bacteriocin -
  SRT_RS01445 - 275224..275434 (+) 211 Protein_252 bacteriocin secretion protein -

Sequence

Protein


Download         Length: 250 a.a.        Molecular weight: 29282.60 Da        Isoelectric Point: 7.8277

>NTDB_id=66160 SRT_RS01400 WP_128832792.1 269918..270670(+) (comE/blpR) [Streptococcus troglodytae strain TKU 31]
MISIFVLEDDFLQQGRLETTIAAIMEEKNWSYKELTIFGKPQQLIDTIPEKGSHQIFFLDIEIKKEEKKGLEVANQIRQH
NPSAVIVFVTTHSEFMPLTFQYQVSALDFIDKSLNPEEFSSRIVSALYYAMENSQKNGQSEELFIFHSSETQFQVPFAEI
LYFETSSTAHKLCLYTYDERIEFYGSMSDIIKMDKRLFQCHRSFIVNPANITRIDRKKRLAYFRNNKSCLISRTKLTKLR
AVIADQRRAK

Nucleotide


Download         Length: 753 bp        

>NTDB_id=66160 SRT_RS01400 WP_128832792.1 269918..270670(+) (comE/blpR) [Streptococcus troglodytae strain TKU 31]
ATGATTTCTATTTTTGTATTGGAAGATGATTTTTTACAGCAAGGACGTCTTGAAACCACCATTGCAGCTATTATGGAAGA
AAAAAACTGGTCTTATAAAGAATTGACTATTTTTGGAAAACCACAACAACTTATTGATACTATCCCAGAAAAGGGCAGTC
ACCAGATTTTCTTTTTGGATATTGAAATCAAAAAAGAGGAAAAGAAAGGACTGGAAGTAGCTAATCAGATTAGACAGCAT
AATCCTAGTGCGGTTATTGTCTTTGTCACGACACATTCTGAGTTTATGCCCCTCACTTTTCAGTATCAGGTATCTGCTTT
GGATTTTATTGATAAATCTTTGAATCCTGAGGAGTTCTCCAGCCGCATTGTATCAGCGCTGTATTATGCTATGGAAAACA
GCCAGAAGAATGGTCAATCAGAGGAACTTTTTATTTTCCATTCATCTGAAACTCAGTTTCAGGTCCCTTTTGCTGAGATT
CTGTATTTTGAAACATCTTCAACAGCCCATAAGCTCTGCCTTTATACTTATGATGAACGGATTGAATTTTATGGTAGTAT
GTCTGACATTATTAAAATGGATAAGAGACTTTTTCAGTGCCATCGCTCTTTTATTGTCAATCCTGCCAATATTACCCGTA
TTGATCGGAAAAAACGCTTGGCCTATTTTCGAAATAATAAGTCTTGTCTTATTTCACGAACTAAGTTAACAAAACTGAGA
GCTGTGATTGCTGATCAAAGGAGAGCAAAATGA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(4-123)

LytTr DNA-binding domain (LytTR)

(153-242)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A1L7LH43

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comE/blpR Streptococcus mutans UA159

97.2

100

0.972
  comE/comE1 Streptococcus equinus JB1

46.473

96.4

0.448
  comE Streptococcus infantis strain Atu-4

40.891

98.8

0.404
  comE Streptococcus mitis NCTC 12261

40.486

98.8

0.4
  comE/comE2 Streptococcus equinus JB1

41.079

96.4

0.396
  comE Streptococcus pneumoniae Rx1

40.081

98.8

0.396
  comE Streptococcus mitis SK321

40.081

98.8

0.396
  comE Streptococcus pneumoniae D39

40.081

98.8

0.396
  comE Streptococcus pneumoniae R6

40.081

98.8

0.396
  comE Streptococcus pneumoniae TIGR4

40.081

98.8

0.396
  comE/comE2 Streptococcus gordonii strain NCTC7865

37.551

98

0.368
  comE/comE1 Streptococcus gordonii str. Challis substr. CH1

37.551

98

0.368

Multiple sequence alignment