Detailed information    

insolico Bioinformatically predicted

Overview

Name   comGC/cglC   Type   Machinery gene
Locus tag   LQ044_RS09055 Genome accession   NZ_CP088200
Coordinates   1830353..1830628 (-) Length   91 a.a.
NCBI ID   WP_002356991.1    Uniprot ID   A0A1B4XPV0
Organism   Enterococcus faecalis strain S39-4     
Function   dsDNA binding to the cell surface; assembly of the pseudopilus (predicted from homology)   
DNA binding and uptake

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Prophage 1790063..1848735 1830353..1830628 within 0


Gene organization within MGE regions


Location: 1790063..1848735
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  LQ044_RS08780 (LQ044_08780) - 1790063..1791070 (-) 1008 WP_002357063.1 class I SAM-dependent methyltransferase -
  LQ044_RS08785 (LQ044_08785) comGG 1791199..1791552 (-) 354 WP_002381743.1 competence type IV pilus minor pilin ComGG -
  LQ044_RS08790 (LQ044_08790) comGF 1791552..1791986 (-) 435 WP_002357060.1 competence type IV pilus minor pilin ComGF -
  LQ044_RS08795 (LQ044_08795) - 1791976..1792347 (-) 372 WP_170310356.1 type II secretion system protein -
  LQ044_RS08800 (LQ044_08800) hemH 1793102..1794043 (-) 942 WP_033624657.1 ferrochelatase -
  LQ044_RS08810 (LQ044_08810) - 1794787..1795038 (-) 252 WP_002364188.1 hypothetical protein -
  LQ044_RS08815 (LQ044_08815) - 1795110..1795310 (-) 201 WP_002357053.1 cold-shock protein -
  LQ044_RS08820 (LQ044_08820) - 1796147..1797448 (-) 1302 WP_002388176.1 LysM peptidoglycan-binding domain-containing protein -
  LQ044_RS08825 (LQ044_08825) - 1797461..1797841 (-) 381 WP_002378446.1 phage holin family protein -
  LQ044_RS08830 (LQ044_08830) - 1797852..1797974 (-) 123 WP_002368228.1 XkdX family protein -
  LQ044_RS08835 (LQ044_08835) - 1797976..1798371 (-) 396 WP_002363385.1 hypothetical protein -
  LQ044_RS08840 (LQ044_08840) - 1798390..1798842 (-) 453 WP_002363384.1 hypothetical protein -
  LQ044_RS08845 (LQ044_08845) - 1798859..1799599 (-) 741 WP_002363383.1 hypothetical protein -
  LQ044_RS08850 (LQ044_08850) - 1799605..1801050 (-) 1446 WP_002378447.1 phage tail spike protein -
  LQ044_RS08855 (LQ044_08855) - 1801050..1801772 (-) 723 WP_002363380.1 hypothetical protein -
  LQ044_RS08860 (LQ044_08860) - 1801769..1806223 (-) 4455 WP_002398616.1 phage tail tape measure protein -
  LQ044_RS08865 (LQ044_08865) - 1806210..1806515 (-) 306 WP_002364305.1 hypothetical protein -
  LQ044_RS08870 (LQ044_08870) - 1806584..1806982 (-) 399 WP_002388187.1 tail assembly chaperone -
  LQ044_RS08875 (LQ044_08875) - 1807045..1807353 (-) 309 WP_002388188.1 hypothetical protein -
  LQ044_RS08880 (LQ044_08880) - 1807356..1807961 (-) 606 WP_002388189.1 phage major tail protein, TP901-1 family -
  LQ044_RS08885 (LQ044_08885) - 1807980..1808372 (-) 393 WP_002363373.1 DUF3168 domain-containing protein -
  LQ044_RS08890 (LQ044_08890) - 1808369..1808707 (-) 339 WP_002388190.1 HK97-gp10 family putative phage morphogenesis protein -
  LQ044_RS08895 (LQ044_08895) - 1808704..1808979 (-) 276 WP_002378454.1 hypothetical protein -
  LQ044_RS08900 (LQ044_08900) - 1808976..1809308 (-) 333 WP_002363369.1 phage head-tail connector protein -
  LQ044_RS08905 (LQ044_08905) - 1809379..1810275 (-) 897 WP_002363368.1 hypothetical protein -
  LQ044_RS08910 (LQ044_08910) - 1810289..1810924 (-) 636 WP_010710204.1 DUF4355 domain-containing protein -
  LQ044_RS08915 (LQ044_08915) - 1811047..1811973 (-) 927 WP_002388191.1 minor capsid protein -
  LQ044_RS08920 (LQ044_08920) - 1811966..1813450 (-) 1485 WP_142958129.1 phage portal protein -
  LQ044_RS08925 (LQ044_08925) - 1813450..1814733 (-) 1284 WP_002398613.1 PBSX family phage terminase large subunit -
  LQ044_RS08930 (LQ044_08930) - 1814714..1815148 (-) 435 WP_002364295.1 terminase small subunit -
  LQ044_RS08935 (LQ044_08935) - 1815180..1815410 (-) 231 WP_002364294.1 hypothetical protein -
  LQ044_RS08940 (LQ044_08940) - 1816173..1816844 (+) 672 WP_002398611.1 hypothetical protein -
  LQ044_RS08945 (LQ044_08945) - 1816837..1817646 (-) 810 WP_002388196.1 hypothetical protein -
  LQ044_RS08950 (LQ044_08950) - 1818279..1818695 (-) 417 WP_002388198.1 ArpU family phage packaging/lysis transcriptional regulator -
  LQ044_RS08955 (LQ044_08955) - 1819602..1820036 (-) 435 WP_002372046.1 RusA family crossover junction endodeoxyribonuclease -
  LQ044_RS08960 (LQ044_08960) - 1820045..1820344 (-) 300 WP_002372047.1 MazG-like family protein -
  LQ044_RS08965 (LQ044_08965) - 1820345..1820647 (-) 303 WP_002368214.1 hypothetical protein -
  LQ044_RS08970 (LQ044_08970) - 1820651..1821613 (-) 963 WP_002372048.1 Lin1244/Lin1753 domain-containing protein -
  LQ044_RS08975 (LQ044_08975) - 1821627..1822517 (-) 891 WP_002364218.1 recombinase RecT -
  LQ044_RS08980 (LQ044_08980) - 1822520..1823461 (-) 942 WP_002364219.1 lambda-exonuclease family protein -
  LQ044_RS08985 (LQ044_08985) - 1823559..1823786 (-) 228 WP_002364220.1 hypothetical protein -
  LQ044_RS08990 (LQ044_08990) - 1823786..1824109 (-) 324 WP_002380444.1 hypothetical protein -
  LQ044_RS08995 (LQ044_08995) - 1824153..1824338 (-) 186 WP_002364222.1 hypothetical protein -
  LQ044_RS09000 (LQ044_09000) - 1824329..1824523 (-) 195 WP_002364223.1 hypothetical protein -
  LQ044_RS09005 (LQ044_09005) - 1824576..1824758 (+) 183 WP_002364224.1 YegP family protein -
  LQ044_RS09010 (LQ044_09010) - 1824798..1825523 (-) 726 WP_025187960.1 ORF6C domain-containing protein -
  LQ044_RS09015 (LQ044_09015) - 1825562..1825873 (-) 312 WP_002381719.1 hypothetical protein -
  LQ044_RS14785 - 1825885..1826052 (-) 168 WP_002388204.1 hypothetical protein -
  LQ044_RS09020 (LQ044_09020) - 1826470..1826667 (-) 198 WP_010712611.1 hypothetical protein -
  LQ044_RS09025 (LQ044_09025) - 1826680..1826862 (-) 183 WP_002388205.1 hypothetical protein -
  LQ044_RS09030 (LQ044_09030) - 1827154..1827489 (+) 336 WP_002388206.1 helix-turn-helix transcriptional regulator -
  LQ044_RS09035 (LQ044_09035) - 1827508..1827852 (+) 345 WP_002388207.1 ImmA/IrrE family metallo-endopeptidase -
  LQ044_RS09040 (LQ044_09040) - 1827910..1828638 (+) 729 WP_002388208.1 potassium channel family protein -
  LQ044_RS09045 (LQ044_09045) - 1828738..1829886 (+) 1149 WP_002388210.1 site-specific integrase -
  LQ044_RS09050 (LQ044_09050) comGD 1829914..1830356 (-) 443 Protein_1759 competence type IV pilus minor pilin ComGD -
  LQ044_RS09055 (LQ044_09055) comGC/cglC 1830353..1830628 (-) 276 WP_002356991.1 competence type IV pilus major pilin ComGC Machinery gene
  LQ044_RS09060 (LQ044_09060) comGB 1830628..1831674 (-) 1047 WP_002356990.1 competence type IV pilus assembly protein ComGB -
  LQ044_RS09065 (LQ044_09065) comGA 1831631..1832599 (-) 969 WP_002364362.1 competence type IV pilus ATPase ComGA -
  LQ044_RS09070 (LQ044_09070) - 1832840..1834168 (-) 1329 WP_002356988.1 amino acid permease -
  LQ044_RS09075 (LQ044_09075) rlmN 1834458..1835531 (-) 1074 WP_002381713.1 23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN -
  LQ044_RS09080 (LQ044_09080) - 1835657..1837486 (-) 1830 WP_002398606.1 ABC transporter permease -
  LQ044_RS09085 (LQ044_09085) - 1837476..1838225 (-) 750 WP_002381711.1 ABC transporter ATP-binding protein -
  LQ044_RS09090 (LQ044_09090) - 1838343..1839044 (-) 702 WP_002364244.1 GntR family transcriptional regulator -
  LQ044_RS09095 (LQ044_09095) - 1839175..1841598 (-) 2424 WP_002380448.1 DNA translocase FtsK -
  LQ044_RS09100 (LQ044_09100) - 1841912..1843123 (-) 1212 WP_002380449.1 NAD(P)/FAD-dependent oxidoreductase -
  LQ044_RS09105 (LQ044_09105) - 1843152..1844057 (-) 906 WP_002360016.1 prenyltransferase -
  LQ044_RS09110 (LQ044_09110) - 1844179..1845159 (+) 981 WP_002360015.1 polyprenyl synthetase family protein -
  LQ044_RS09115 (LQ044_09115) cydC 1845239..1847005 (-) 1767 WP_002381710.1 thiol reductant ABC exporter subunit CydC -
  LQ044_RS09120 (LQ044_09120) cydD 1847002..1848735 (-) 1734 WP_002381709.1 thiol reductant ABC exporter subunit CydD -

Sequence

Protein


Download         Length: 91 a.a.        Molecular weight: 10464.41 Da        Isoelectric Point: 9.3192

>NTDB_id=633251 LQ044_RS09055 WP_002356991.1 1830353..1830628(-) (comGC/cglC) [Enterococcus faecalis strain S39-4]
MKKKQKYAGFTLLEMLIVLLIISVLILLFVPNLAKHKETVDKKGNEAIVKIVESQIELYTLEKNKTPSLNELVNEGYITK
EQLDKYTAEKQ

Nucleotide


Download         Length: 276 bp        

>NTDB_id=633251 LQ044_RS09055 WP_002356991.1 1830353..1830628(-) (comGC/cglC) [Enterococcus faecalis strain S39-4]
ATGAAAAAGAAACAAAAATACGCAGGGTTTACATTATTAGAAATGTTGATTGTCTTATTGATTATTTCCGTATTGATTTT
ACTTTTTGTCCCTAACTTAGCGAAACATAAAGAAACAGTTGATAAAAAAGGCAATGAAGCAATCGTAAAAATTGTAGAAT
CACAAATCGAGCTCTACACACTAGAAAAAAATAAGACGCCTTCCTTAAATGAATTAGTCAACGAAGGCTACATTACTAAA
GAGCAGTTAGATAAATATACAGCAGAAAAGCAATGA

Domains

Predicted by InterproScan.

Prokaryotic N-terminal methylation motif (N_methyl)

(5-28)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A1B4XPV0

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comGC/cglC Streptococcus pneumoniae Rx1

63.095

92.308

0.582
  comGC/cglC Streptococcus pneumoniae D39

63.095

92.308

0.582
  comGC/cglC Streptococcus pneumoniae R6

63.095

92.308

0.582
  comGC/cglC Streptococcus pneumoniae TIGR4

63.095

92.308

0.582
  comGC/cglC Streptococcus mitis NCTC 12261

61.905

92.308

0.571
  comGC/cglC Streptococcus mitis SK321

61.176

93.407

0.571
  comGC Lactococcus lactis subsp. cremoris KW2

58.14

94.505

0.549
  comYC Streptococcus gordonii str. Challis substr. CH1

56.322

95.604

0.538
  comYC Streptococcus suis isolate S10

52.326

94.505

0.495
  comYC Streptococcus mutans UA159

57.692

85.714

0.495
  comYC Streptococcus mutans UA140

57.692

85.714

0.495
  comGC Latilactobacillus sakei subsp. sakei 23K

46.154

100

0.462
  comGC Staphylococcus aureus MW2

46.835

86.813

0.407
  comGC Staphylococcus aureus N315

46.835

86.813

0.407
  comGC Bacillus subtilis subsp. subtilis str. 168

48.649

81.319

0.396