Detailed information NTG0061922

Bioinformatically predicted

Overview

• Name: comE
• Type: Regulator
• Locus tag: SIR_RS19455
• Genome accession: NC_022246
• Coordinates: 1991004..1991753 (-)
• Length: 249 a.a.
• NCBI ID: WP_003075488.1
• Uniprot ID: T1ZH01
• Organism: Streptococcus intermedius B196
• Function: activate transcription of early competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1986004..1996753

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SIR_RS19435 (SIR_1895)	-	1986408..1988030 (+)	1623	WP_021003374.1	ATP-binding cassette domain-containing protein	-
SIR_RS19440 (SIR_1896)	-	1988104..1990680 (+)	2577	WP_021003375.1	YfhO family protein	-
SIR_RS19455 (SIR_1899)	comE	1991004..1991753 (-)	750	WP_003075488.1	competence system response regulator transcription factor ComE	Regulator
SIR_RS19460 (SIR_1900)	comD/comD1	1991753..1993078 (-)	1326	WP_003075490.1	GHKL domain-containing protein	Regulator
SIR_RS19790 (SIR_1901)	-	1993095..1993241 (-)	147	WP_003075491.1	bacteriocin	-
SIR_RS19475 (SIR_1903)	rlmH	1993518..1993997 (-)	480	WP_003075603.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
SIR_RS19480 (SIR_1904)	htrA	1994201..1995391 (+)	1191	WP_020999302.1	S1C family serine protease	Regulator
SIR_RS19485 (SIR_1905)	spo0J	1995446..1996213 (+)	768	WP_021003376.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 249 a.a.
• Molecular weight: 29207.78 Da
• Isoelectric Point: 8.0443

>NTDB_id=61922 SIR_RS19455 WP_003075488.1 1991004..1991753(-) (comE) [Streptococcus intermedius B196]
MKVLVLEDEISHQVRMETTLAEIAKEMGISIKVKVTGKIREFKEYIENDEVNQLYFLDIDIKGEETKGLEIAKFIRHHNP
YAIIVFVTTKSEFATMTFKYKVSALDFVDKNLNDVAFKKHIKDSIEYTKATLIENKDMVDYFEYSFRGGEVRMPFNDILY
IETTGSSHKLRIVGKNFFKEFYGTIADIQEKDKETQRFFSPHKSYLVNIGNIKSYDKKMKEIIFYEDHRCPITRMKIGKL
KTILEESKG

Nucleotide

• Length: 750 bp

>NTDB_id=61922 SIR_RS19455 WP_003075488.1 1991004..1991753(-) (comE) [Streptococcus intermedius B196]
ATGAAAGTATTAGTATTAGAAGATGAAATTTCACATCAAGTAAGAATGGAAACAACTTTGGCAGAGATTGCAAAAGAAAT
GGGAATTTCTATCAAAGTTAAAGTAACTGGAAAAATAAGAGAATTTAAAGAATATATTGAGAATGATGAAGTAAATCAAT
TATACTTTTTAGATATTGATATTAAAGGGGAAGAGACAAAAGGTTTAGAAATAGCAAAATTTATACGTCATCATAATCCG
TATGCTATTATTGTTTTTGTTACAACGAAATCAGAATTTGCTACTATGACTTTTAAATATAAAGTTTCTGCACTAGATTT
TGTTGATAAAAATTTGAATGATGTTGCTTTTAAAAAACATATAAAAGATAGTATCGAGTATACAAAAGCAACGTTGATTG
AAAATAAAGATATGGTTGATTATTTTGAATATAGTTTTCGTGGTGGAGAAGTTAGAATGCCATTTAATGATATTTTATAT
ATTGAAACGACAGGTTCTTCTCATAAATTAAGAATTGTAGGTAAAAACTTTTTTAAAGAATTTTATGGTACTATTGCAGA
TATTCAAGAAAAAGACAAGGAGACACAGCGTTTCTTTTCACCTCATAAATCTTATTTAGTTAATATTGGAAATATTAAGA
GTTATGACAAAAAAATGAAAGAAATTATTTTTTATGAAGATCACCGTTGCCCAATTACTCGAATGAAAATTGGAAAGTTG
AAAACTATTTTAGAGGAGTCAAAAGGATGA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (3-121)

• LytTr DNA-binding domain (LytTR) (152-244)

3D structure

• AlphaFold DB: T1ZH01

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE	Streptococcus mitis NCTC 12261	71.02	98.394	0.699
comE/comE2	Streptococcus gordonii strain NCTC7865	71.311	97.992	0.699
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	71.311	97.992	0.699
comE	Streptococcus infantis strain Atu-4	70.612	98.394	0.695
comE	Streptococcus mitis SK321	70.204	98.394	0.691
comE	Streptococcus pneumoniae Rx1	69.796	98.394	0.687
comE	Streptococcus pneumoniae D39	69.796	98.394	0.687
comE	Streptococcus pneumoniae R6	69.796	98.394	0.687
comE	Streptococcus pneumoniae TIGR4	69.796	98.394	0.687
comE/blpR	Streptococcus mutans UA159	40.161	100	0.402
comE/comE2	Streptococcus equinus JB1	35.019	100	0.361