Detailed information NTG0580358

Bioinformatically predicted

Overview

• Name: comE
• Type: Regulator
• Locus tag: I6L86_RS03405
• Genome accession: NZ_CP077259
• Coordinates: 746368..747120 (-)
• Length: 250 a.a.
• NCBI ID: WP_000866073.1
• Uniprot ID: A0A081S8D7
• Organism: Streptococcus mitis strain FDAARGOS 1456
• Function: activate transcription of early competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 741368..752120

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
I6L86_RS03385 (I6L86_03385)	-	742813..745455 (-)	2643	WP_000472064.1	YhgE/Pip domain-containing protein	-
I6L86_RS03390 (I6L86_03390)	-	745583..746125 (+)	543	WP_001158274.1	TetR/AcrR family transcriptional regulator	-
I6L86_RS03405 (I6L86_03405)	comE	746368..747120 (-)	753	WP_000866073.1	competence system response regulator transcription factor ComE	Regulator
I6L86_RS03410 (I6L86_03410)	comD	747117..748442 (-)	1326	WP_020902616.1	competence system sensor histidine kinase ComD	Regulator
I6L86_RS03415 (I6L86_03415)	comC	748455..748577 (-)	123	WP_004238992.1	competence-stimulating peptide ComC	Regulator
I6L86_RS03425 (I6L86_03425)	rlmH	748860..749339 (-)	480	WP_000695934.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
I6L86_RS03430 (I6L86_03430)	htrA	749522..750703 (+)	1182	WP_000681587.1	S1C family serine protease	Regulator
I6L86_RS03435 (I6L86_03435)	spo0J	750761..751519 (+)	759	WP_000410370.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 250 a.a.
• Molecular weight: 29947.32 Da
• Isoelectric Point: 6.9819

>NTDB_id=580358 I6L86_RS03405 WP_000866073.1 746368..747120(-) (comE) [Streptococcus mitis strain FDAARGOS 1456]
MKVLILEDVIEHQVRLERILDEISKESNIPISYKTTGKVREFKEYIENDEVNQLYFLDIDIHGIEKKGFEVAQFIRHHNP
YAIIVFITSRSEFATLTYKYQVSALDFVDKDINDELFKKRIEQNIFYTKSMLLENEDVVDYFDYNYKGNDLKIPYHDILY
IETTGVSHKLRIIGKNFAKEFYGTMTDIQEKDKHTQRFYSPHKSFLVNIGNIREIDRKNLEIVFYEDHRCPISRLKIRKL
KDILEKKSQK

Nucleotide

• Length: 753 bp

>NTDB_id=580358 I6L86_RS03405 WP_000866073.1 746368..747120(-) (comE) [Streptococcus mitis strain FDAARGOS 1456]
ATGAAAGTTTTAATTTTAGAAGATGTTATTGAACATCAAGTGAGACTAGAGAGAATATTGGATGAAATTTCGAAAGAATC
GAATATTCCAATATCATACAAGACAACGGGAAAAGTTCGTGAGTTTAAGGAATATATCGAAAATGATGAAGTAAACCAGC
TTTATTTTCTAGATATTGATATTCATGGAATTGAGAAAAAAGGGTTTGAAGTTGCTCAGTTTATTCGTCATCACAATCCT
TACGCTATTATCGTCTTTATCACCAGTCGATCAGAGTTTGCGACTCTAACCTATAAATACCAGGTATCAGCCTTAGATTT
TGTTGATAAGGATATCAATGATGAGTTGTTTAAGAAGAGAATTGAGCAAAATATCTTCTACACGAAGAGTATGTTACTTG
AAAATGAAGATGTTGTAGATTATTTTGACTACAATTACAAGGGAAATGATTTAAAAATTCCTTACCATGATATTTTGTAT
ATTGAAACGACAGGTGTCTCTCATAAATTACGCATTATTGGTAAGAATTTTGCCAAAGAGTTTTACGGTACCATGACAGA
TATTCAGGAAAAGGACAAACATACTCAGCGATTTTATTCTCCTCATAAGTCATTTTTGGTAAATATAGGCAATATCAGAG
AAATTGATCGAAAAAACTTAGAAATTGTTTTCTATGAAGACCATCGTTGTCCTATTTCAAGATTAAAAATTAGAAAATTA
AAAGATATTCTAGAGAAAAAATCTCAAAAGTGA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (3-121)

• LytTr DNA-binding domain (LytTR) (151-244)

3D structure

• AlphaFold DB: A0A081S8D7

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE	Streptococcus mitis NCTC 12261	100	100	1
comE	Streptococcus mitis SK321	99.2	100	0.992
comE	Streptococcus pneumoniae Rx1	98.4	100	0.984
comE	Streptococcus pneumoniae D39	98.4	100	0.984
comE	Streptococcus pneumoniae R6	98.4	100	0.984
comE	Streptococcus pneumoniae TIGR4	98.4	100	0.984
comE	Streptococcus infantis strain Atu-4	92.8	100	0.928
comE/comE2	Streptococcus gordonii strain NCTC7865	64	100	0.64
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	64	100	0.64
comE/blpR	Streptococcus mutans UA159	41.7	98.8	0.412