Detailed information    

insolico Bioinformatically predicted

Overview

Name   htrA   Type   Regulator
Locus tag   I6L86_RS03430 Genome accession   NZ_CP077259
Coordinates   749522..750703 (+) Length   393 a.a.
NCBI ID   WP_000681587.1    Uniprot ID   A0A0F2DYC6
Organism   Streptococcus mitis strain FDAARGOS 1456     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 744522..755703
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  I6L86_RS03390 (I6L86_03390) - 745583..746125 (+) 543 WP_001158274.1 TetR/AcrR family transcriptional regulator -
  I6L86_RS03405 (I6L86_03405) comE 746368..747120 (-) 753 WP_000866073.1 competence system response regulator transcription factor ComE Regulator
  I6L86_RS03410 (I6L86_03410) comD 747117..748442 (-) 1326 WP_020902616.1 competence system sensor histidine kinase ComD Regulator
  I6L86_RS03415 (I6L86_03415) comC 748455..748577 (-) 123 WP_004238992.1 competence-stimulating peptide ComC Regulator
  I6L86_RS03425 (I6L86_03425) rlmH 748860..749339 (-) 480 WP_000695934.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  I6L86_RS03430 (I6L86_03430) htrA 749522..750703 (+) 1182 WP_000681587.1 S1C family serine protease Regulator
  I6L86_RS03435 (I6L86_03435) spo0J 750761..751519 (+) 759 WP_000410370.1 ParB/RepB/Spo0J family partition protein Regulator
  I6L86_RS03440 (I6L86_03440) dnaA 751732..753093 (+) 1362 WP_000660620.1 chromosomal replication initiator protein DnaA -
  I6L86_RS03445 (I6L86_03445) dnaN 753252..754388 (+) 1137 WP_000581174.1 DNA polymerase III subunit beta -
  I6L86_RS03450 (I6L86_03450) - 754453..754647 (+) 195 WP_000285186.1 DUF951 domain-containing protein -

Sequence

Protein


Download         Length: 393 a.a.        Molecular weight: 41729.49 Da        Isoelectric Point: 5.7805

>NTDB_id=580361 I6L86_RS03430 WP_000681587.1 749522..750703(+) (htrA) [Streptococcus mitis strain FDAARGOS 1456]
MKHLKTFYKKGFQLLVVIVISFFSGALGSFSINQLTQKSTESTSNNNSTITQTAYKNENSTTQAVNKVKDAVVSVITYSA
NRQNSVFGNDDTDTDSQQISSEGSGVIYKKNDKEAYIVTNNHVINGASKVDIRLSDGTKVPGEIVGADTFSDIAVVKISS
EKVTTVAEFGDSSKLTVGETAIAIGSPLGSEYANTVTQGIVSSLNRNVSLKSEDGQAISTKAIQTDTAINPGNSGGPLIN
IQGQVIGITSSKIATNGGTSVEGLGFAIPANDAINIIEQLEKNGKVTRPALGIQMVNLSNINTSDIRRLNIPSNVTSGVV
VRSVQSNMPANGHLEKYDVITKVDDKEIASSTDLQSALYNHSIGDTIKITYYRNGKEETTSIKLDKSSGDLES

Nucleotide


Download         Length: 1182 bp        

>NTDB_id=580361 I6L86_RS03430 WP_000681587.1 749522..750703(+) (htrA) [Streptococcus mitis strain FDAARGOS 1456]
ATGAAACATTTAAAAACATTTTACAAAAAAGGGTTTCAATTATTAGTCGTTATCGTCATTAGCTTTTTTAGTGGAGCCTT
GGGTAGCTTTTCAATAAACCAACTAACTCAAAAAAGTACTGAAAGTACCTCTAACAACAATAGTACTATTACACAGACTG
CCTATAAGAATGAAAATTCAACAACACAGGCTGTTAACAAAGTAAAAGATGCCGTTGTTTCTGTTATTACTTATTCAGCA
AACAGACAAAATAGCGTATTTGGTAATGATGATACTGACACAGATTCTCAGCAAATCTCTAGTGAAGGATCTGGGGTTAT
TTATAAAAAGAATGATAAAGAAGCTTACATCGTCACCAACAATCACGTTATAAATGGTGCCAGCAAAGTAGATATTCGTT
TGTCAGATGGAACTAAAGTACCTGGAGAAATCGTCGGAGCTGATACTTTCTCTGATATTGCTGTCGTCAAAATCTCTTCA
GAAAAAGTGACAACAGTAGCTGAATTTGGTGATTCTAGCAAGTTAACCGTAGGAGAAACTGCTATTGCCATCGGTAGCCC
ATTAGGTTCTGAATATGCTAATACTGTCACTCAAGGTATCGTATCTAGTCTTAATCGAAATGTATCTTTAAAATCTGAAG
ATGGACAAGCCATTTCTACAAAAGCCATCCAAACTGATACTGCTATTAACCCAGGTAACTCTGGTGGCCCACTAATCAAT
ATTCAAGGACAGGTTATCGGAATTACCTCAAGTAAAATTGCCACAAATGGAGGAACATCTGTAGAAGGTCTTGGTTTTGC
AATCCCTGCAAATGATGCTATCAATATTATTGAACAGTTGGAAAAGAACGGAAAAGTTACTCGTCCAGCTTTGGGAATTC
AAATGGTCAATCTCTCAAATATTAATACAAGTGATATTAGAAGACTGAATATTCCAAGCAATGTAACATCTGGTGTAGTT
GTTCGTTCTGTGCAAAGTAATATGCCTGCCAATGGTCACCTTGAAAAATACGATGTTATTACAAAAGTAGATGACAAGGA
AATTGCTTCATCAACAGACTTACAAAGTGCTCTTTACAATCATTCTATCGGAGATACCATTAAAATAACTTACTATCGTA
ACGGTAAAGAAGAAACTACATCTATTAAACTTGACAAGAGTTCAGGTGATTTAGAATCTTAA

Domains

Predicted by InterproScan.

PDZ domain (PDZ_2)

(289-384)

Trypsin-like peptidase domain (Trypsin_2)

(103-248)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A0F2DYC6

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  htrA Streptococcus mitis NCTC 12261

100

100

1
  htrA Streptococcus pneumoniae Rx1

97.201

100

0.972
  htrA Streptococcus pneumoniae D39

97.201

100

0.972
  htrA Streptococcus pneumoniae R6

97.201

100

0.972
  htrA Streptococcus pneumoniae TIGR4

97.201

100

0.972
  htrA Streptococcus gordonii str. Challis substr. CH1

66.332

100

0.672
  htrA Streptococcus mutans UA159

54.684

100

0.55