Detailed information    

insolico Bioinformatically predicted

Overview


Name   comC   Type   Regulator
Locus tag   I6L86_RS03415 Genome accession   NZ_CP077259
Coordinates   748455..748577 (-) Length   40 a.a.
NCBI ID   WP_004238992.1    Uniprot ID   O33675
Organism   Streptococcus mitis strain FDAARGOS 1456     
Function   binding to ComD; induce autophosphorylation of ComD (predicted from homology)   
Competence regulation

Genomic Context


Location: 743455..753577
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  I6L86_RS03390 (I6L86_03390) - 745583..746125 (+) 543 WP_001158274.1 TetR/AcrR family transcriptional regulator -
  I6L86_RS03405 (I6L86_03405) comE 746368..747120 (-) 753 WP_000866073.1 competence system response regulator transcription factor ComE Regulator
  I6L86_RS03410 (I6L86_03410) comD 747117..748442 (-) 1326 WP_020902616.1 competence system sensor histidine kinase ComD Regulator
  I6L86_RS03415 (I6L86_03415) comC 748455..748577 (-) 123 WP_004238992.1 competence-stimulating peptide ComC Regulator
  I6L86_RS03425 (I6L86_03425) rlmH 748860..749339 (-) 480 WP_000695934.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  I6L86_RS03430 (I6L86_03430) htrA 749522..750703 (+) 1182 WP_000681587.1 S1C family serine protease Regulator
  I6L86_RS03435 (I6L86_03435) spo0J 750761..751519 (+) 759 WP_000410370.1 ParB/RepB/Spo0J family partition protein Regulator
  I6L86_RS03440 (I6L86_03440) dnaA 751732..753093 (+) 1362 WP_000660620.1 chromosomal replication initiator protein DnaA -

Sequence


Protein


Download         Length: 40 a.a.        Molecular weight: 4897.64 Da        Isoelectric Point: 10.6104

>NTDB_id=580360 I6L86_RS03415 WP_004238992.1 748455..748577(-) (comC) [Streptococcus mitis strain FDAARGOS 1456]
MKNTVNLDKFVELKEKDLQNIQGGEIRQTHNIFFNFFKRR

Nucleotide


Download         Length: 123 bp        

>NTDB_id=580360 I6L86_RS03415 WP_004238992.1 748455..748577(-) (comC) [Streptococcus mitis strain FDAARGOS 1456]
ATGAAAAACACAGTTAATTTAGATAAGTTTGTAGAATTGAAGGAAAAAGACTTGCAAAATATTCAAGGTGGGGAGATAAG
GCAAACACATAATATTTTCTTTAATTTCTTTAAAAGAAGATAA

Domains


Predicted by InterproScan.

(1-27)


Secondary structure


Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure


Source ID Structure
  AlphaFold DB O33675

Transmembrane helices


Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.



Visualization of predicted probability:


Similar proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comC Streptococcus mitis NCTC 12261

100

100

1

  comC Streptococcus mitis SK321

66.667

90

0.6

  comC/comC2 Streptococcus pneumoniae A66

57.5

100

0.575

  comC/comC2 Streptococcus pneumoniae TIGR4

57.5

100

0.575

  comC/comC1 Streptococcus pneumoniae Rx1

74.074

67.5

0.5

  comC/comC1 Streptococcus pneumoniae R6

74.074

67.5

0.5

  comC/comC1 Streptococcus pneumoniae G54

74.074

67.5

0.5

  comC/comC1 Streptococcus pneumoniae D39

74.074

67.5

0.5