Detailed information NTG0516971

Bioinformatically predicted

Overview

• Name: comE
• Type: Regulator
• Locus tag: I6H78_RS05400
• Genome accession: NZ_CP066059
• Coordinates: 1109083..1109835 (+)
• Length: 250 a.a.
• NCBI ID: WP_000866079.1
• Uniprot ID: A0A081R422
• Organism: Streptococcus oralis strain FDAARGOS_1021
• Function: activate transcription of early competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1104083..1114835

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
I6H78_RS05370 (I6H78_05370)	spo0J	1104662..1105420 (-)	759	WP_198459028.1	ParB/RepB/Spo0J family partition protein	Regulator
I6H78_RS05375 (I6H78_05375)	htrA	1105478..1106674 (-)	1197	WP_198459029.1	S1C family serine protease	Regulator
I6H78_RS05380 (I6H78_05380)	rlmH	1106860..1107339 (+)	480	WP_198459030.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
I6H78_RS05390 (I6H78_05390)	comC/comC1	1107621..1107746 (+)	126	WP_008282505.1	competence-stimulating peptide ComC	Regulator
I6H78_RS05395 (I6H78_05395)	comD	1107767..1109086 (+)	1320	WP_000054555.1	competence system sensor histidine kinase ComD	Regulator
I6H78_RS05400 (I6H78_05400)	comE	1109083..1109835 (+)	753	WP_000866079.1	competence system response regulator transcription factor ComE	Regulator
I6H78_RS05415 (I6H78_05415)	-	1110072..1110614 (-)	543	WP_033630549.1	TetR/AcrR family transcriptional regulator	-
I6H78_RS05420 (I6H78_05420)	-	1110744..1113398 (+)	2655	WP_198459031.1	YhgE/Pip domain-containing protein	-

Sequence

Protein

• Length: 250 a.a.
• Molecular weight: 29884.23 Da
• Isoelectric Point: 6.9755

>NTDB_id=516971 I6H78_RS05400 WP_000866079.1 1109083..1109835(+) (comE) [Streptococcus oralis strain FDAARGOS_1021]
MKVLILEDVIEHQVRLERILNEISEESNIPISYKTTGKVREFKEYIENDEVNQLYFLDIDIHGIEKKGFEVAQFIRHHNP
YAIIVFITSRSEFATLTYKYQVSALDFVDKDINDELFKKRIEQSIFYTKSMLLENEDVVDYFDYNYKGNDLKIPYHDILY
IETTGVSHKLRIIGKNFAKEFYGTMTDIQEKDKHTQRFYCSHKSFLVNVGNVREIDRKNLEVVFYEDHRCPITRLKVRKL
KDILEKKSKK

Nucleotide

• Length: 753 bp

>NTDB_id=516971 I6H78_RS05400 WP_000866079.1 1109083..1109835(+) (comE) [Streptococcus oralis strain FDAARGOS_1021]
ATGAAAGTATTAATTTTAGAAGATGTTATTGAACATCAAGTGAGACTAGAGAGAATATTAAATGAAATCTCGGAAGAATC
GAATATTCCTATTTCATATAAGACAACAGGAAAAGTTCGTGAGTTTAAGGAATATATCGAAAATGATGAAGTAAACCAGC
TTTATTTCCTAGATATCGATATTCATGGAATCGAGAAAAAAGGCTTTGAAGTGGCTCAATTTATCCGTCATCACAATCCT
TATGCTATTATTGTCTTTATTACTAGTCGCTCTGAATTTGCTACCTTAACGTACAAATACCAGGTATCAGCCCTAGATTT
TGTTGATAAAGATATCAATGATGAGTTGTTCAAAAAACGCATCGAGCAGAGTATTTTTTACACTAAGAGCATGCTGCTTG
AAAACGAAGATGTTGTAGACTATTTTGATTACAACTATAAAGGAAATGATTTGAAAATTCCTTACCATGACATTTTGTAT
ATCGAAACCACAGGAGTTTCTCATAAACTTCGGATTATTGGTAAGAATTTTGCTAAAGAATTCTATGGAACTATGACAGA
TATTCAGGAAAAGGACAAACATACCCAGCGATTTTATTGCTCCCATAAATCTTTCCTTGTCAATGTGGGAAATGTGAGAG
AAATTGATCGAAAGAATTTAGAAGTTGTTTTTTATGAAGATCATCGTTGTCCAATTACTCGTTTAAAAGTCCGCAAACTA
AAAGATATTCTAGAGAAAAAATCTAAAAAGTGA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (3-121)

• LytTr DNA-binding domain (LytTR) (151-244)

3D structure

• AlphaFold DB: A0A081R422

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE	Streptococcus mitis NCTC 12261	95.6	100	0.956
comE	Streptococcus mitis SK321	94.8	100	0.948
comE	Streptococcus pneumoniae Rx1	94	100	0.94
comE	Streptococcus pneumoniae D39	94	100	0.94
comE	Streptococcus pneumoniae R6	94	100	0.94
comE	Streptococcus pneumoniae TIGR4	94	100	0.94
comE	Streptococcus infantis strain Atu-4	93.6	100	0.936
comE/comE2	Streptococcus gordonii strain NCTC7865	63.2	100	0.632
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	63.2	100	0.632
comE/blpR	Streptococcus mutans UA159	40.486	98.8	0.4