Detailed information    

insolico Bioinformatically predicted

Overview

Name   htrA   Type   Regulator
Locus tag   I6H78_RS05375 Genome accession   NZ_CP066059
Coordinates   1105478..1106674 (-) Length   398 a.a.
NCBI ID   WP_198459029.1    Uniprot ID   A0A7T4IR96
Organism   Streptococcus oralis strain FDAARGOS_1021     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 1100478..1111674
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  I6H78_RS05355 (I6H78_05355) - 1101530..1101724 (-) 195 WP_198459026.1 DUF951 domain-containing protein -
  I6H78_RS05360 (I6H78_05360) dnaN 1101789..1102925 (-) 1137 WP_198459027.1 DNA polymerase III subunit beta -
  I6H78_RS05365 (I6H78_05365) dnaA 1103084..1104445 (-) 1362 WP_000660625.1 chromosomal replication initiator protein DnaA -
  I6H78_RS05370 (I6H78_05370) spo0J 1104662..1105420 (-) 759 WP_198459028.1 ParB/RepB/Spo0J family partition protein Regulator
  I6H78_RS05375 (I6H78_05375) htrA 1105478..1106674 (-) 1197 WP_198459029.1 S1C family serine protease Regulator
  I6H78_RS05380 (I6H78_05380) rlmH 1106860..1107339 (+) 480 WP_198459030.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  I6H78_RS05390 (I6H78_05390) comC/comC1 1107621..1107746 (+) 126 WP_008282505.1 competence-stimulating peptide ComC Regulator
  I6H78_RS05395 (I6H78_05395) comD 1107767..1109086 (+) 1320 WP_000054555.1 competence system sensor histidine kinase ComD Regulator
  I6H78_RS05400 (I6H78_05400) comE 1109083..1109835 (+) 753 WP_000866079.1 competence system response regulator transcription factor ComE Regulator
  I6H78_RS05415 (I6H78_05415) - 1110072..1110614 (-) 543 WP_033630549.1 TetR/AcrR family transcriptional regulator -

Sequence

Protein


Download         Length: 398 a.a.        Molecular weight: 41955.73 Da        Isoelectric Point: 6.6578

>NTDB_id=516968 I6H78_RS05375 WP_198459029.1 1105478..1106674(-) (htrA) [Streptococcus oralis strain FDAARGOS_1021]
MKHLQKFYKKGVKVLAIIIIGFLSGALGSFVTLQLYQKQGNQATNNNSGTVTQTSYKNENSTTQAVNKVKDAVVSIITYS
SSSSRQSSVFNADDTNSDSDNQQIASEGSGVIYKKDDKDAYLVTNTHVINGASKVDIRLADGTKVPGEIVGSDTFSDIAV
VKISSEKVTTVAEFGDSSQLSVGETAIAIGSPLGSEYANTVTQGIISSLNRNVSLKSEDGQAISTKAIQTDTAINPGNSG
GPLVNIQGQVIGITSSKIASNGGTSVEGLGFAIPSNDAQNIIKQLESNGKVTRPALGIQMVNLSNVGASDLRKLNIPSGL
TSGVVVRSVQNNMPANGHLQKYDVITKVDDKEIASSTDLQHALYNHAIGDTIKVTYYRNGKEETTSIKLDKNSGDLES

Nucleotide


Download         Length: 1197 bp        

>NTDB_id=516968 I6H78_RS05375 WP_198459029.1 1105478..1106674(-) (htrA) [Streptococcus oralis strain FDAARGOS_1021]
ATGAAACACTTACAAAAATTTTACAAAAAAGGAGTTAAAGTTCTAGCAATCATTATAATCGGATTTTTAAGTGGTGCCTT
AGGAAGTTTCGTAACATTACAACTTTATCAAAAACAAGGAAATCAAGCTACGAATAATAATTCTGGCACTGTCACTCAAA
CATCCTATAAAAATGAAAACTCAACCACTCAAGCAGTAAATAAAGTTAAGGATGCTGTTGTCTCAATCATTACTTATTCT
TCTTCTAGCAGTAGACAAAGTAGTGTATTTAATGCTGACGACACTAATTCTGATTCAGACAATCAACAAATCGCAAGTGA
GGGTTCAGGTGTTATCTATAAAAAAGATGATAAAGATGCCTATCTTGTAACTAATACTCACGTTATCAATGGAGCTTCAA
AAGTTGATATTCGCTTGGCAGATGGTACCAAGGTTCCTGGTGAAATTGTCGGATCTGATACTTTCTCTGATATTGCTGTC
GTTAAAATTTCTTCAGAAAAAGTTACAACAGTAGCAGAATTTGGGGATTCAAGTCAACTTAGTGTTGGAGAAACAGCAAT
TGCCATCGGTAGTCCTTTAGGTTCAGAATATGCTAATACAGTTACACAGGGAATCATCTCAAGTCTTAATCGAAATGTTT
CTCTAAAATCTGAAGATGGTCAAGCTATTTCAACAAAAGCCATTCAAACAGATACAGCCATTAACCCTGGTAACTCTGGT
GGTCCACTTGTAAACATTCAAGGACAAGTAATTGGTATTACATCAAGTAAAATTGCAAGTAATGGTGGAACATCTGTAGA
AGGTCTTGGTTTTGCAATTCCTTCAAACGATGCACAAAATATCATTAAACAACTTGAAAGTAATGGTAAAGTGACTCGTC
CTGCTCTTGGAATTCAAATGGTCAATCTATCAAATGTTGGAGCTAGTGATCTTAGAAAACTTAACATTCCAAGTGGCCTC
ACTTCAGGTGTAGTTGTTCGATCTGTTCAAAACAATATGCCAGCAAATGGACATCTTCAAAAATACGATGTCATTACCAA
AGTTGACGATAAAGAGATTGCTTCATCAACAGACCTACAACACGCTCTTTACAATCATGCTATCGGAGATACTATCAAAG
TAACCTACTACCGTAACGGTAAGGAAGAAACAACCTCAATTAAACTAGATAAGAATTCTGGTGATTTAGAGTCTTAA

Domains

Predicted by InterproScan.

Peptidase family M50 (Peptidase_M50)

(206-393)

Trypsin-like peptidase domain (Trypsin_2)

(108-253)

PDZ domain (PDZ_2)

(294-389)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A7T4IR96

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  htrA Streptococcus mitis NCTC 12261

83.92

100

0.839
  htrA Streptococcus pneumoniae Rx1

83.166

100

0.832
  htrA Streptococcus pneumoniae D39

83.166

100

0.832
  htrA Streptococcus pneumoniae R6

83.166

100

0.832
  htrA Streptococcus pneumoniae TIGR4

83.166

100

0.832
  htrA Streptococcus gordonii str. Challis substr. CH1

66.667

100

0.673
  htrA Streptococcus mutans UA159

54.115

100

0.545