Detailed information    

insolico Bioinformatically predicted

Overview

Name   comD   Type   Regulator
Locus tag   I6H78_RS05395 Genome accession   NZ_CP066059
Coordinates   1107767..1109086 (+) Length   439 a.a.
NCBI ID   WP_000054555.1    Uniprot ID   A0A1X1H723
Organism   Streptococcus oralis strain FDAARGOS_1021     
Function   phosphorylation of ComE (predicted from homology)   
Competence regulation

Genomic Context

Location: 1102767..1114086
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  I6H78_RS05365 (I6H78_05365) dnaA 1103084..1104445 (-) 1362 WP_000660625.1 chromosomal replication initiator protein DnaA -
  I6H78_RS05370 (I6H78_05370) spo0J 1104662..1105420 (-) 759 WP_198459028.1 ParB/RepB/Spo0J family partition protein Regulator
  I6H78_RS05375 (I6H78_05375) htrA 1105478..1106674 (-) 1197 WP_198459029.1 S1C family serine protease Regulator
  I6H78_RS05380 (I6H78_05380) rlmH 1106860..1107339 (+) 480 WP_198459030.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  I6H78_RS05390 (I6H78_05390) comC/comC1 1107621..1107746 (+) 126 WP_008282505.1 competence-stimulating peptide ComC Regulator
  I6H78_RS05395 (I6H78_05395) comD 1107767..1109086 (+) 1320 WP_000054555.1 competence system sensor histidine kinase ComD Regulator
  I6H78_RS05400 (I6H78_05400) comE 1109083..1109835 (+) 753 WP_000866079.1 competence system response regulator transcription factor ComE Regulator
  I6H78_RS05415 (I6H78_05415) - 1110072..1110614 (-) 543 WP_033630549.1 TetR/AcrR family transcriptional regulator -
  I6H78_RS05420 (I6H78_05420) - 1110744..1113398 (+) 2655 WP_198459031.1 YhgE/Pip domain-containing protein -

Sequence

Protein


Download         Length: 439 a.a.        Molecular weight: 50976.92 Da        Isoelectric Point: 6.5044

>NTDB_id=516970 I6H78_RS05395 WP_000054555.1 1107767..1109086(+) (comD) [Streptococcus oralis strain FDAARGOS_1021]
MSLLGFGIVILHIFILTISYELICKVTKKERYLFIACIFVYQSVAEFFFDFISLAGLGIEKFIFPFILYTSIVVLKKYDK
HKGMFISLLLSLLYHSTHTFLSVTLSSITGDAFVIEHEVMFYLGVLLLTYFIIKKIITYFHLELTYFDKDYLYPFLKKVI
VAFFGLHILLFISDIVSTTHHLNSFGSILSTIVFICLLLIFFAMNSHKVQIEKEIALKQKKFEQKHLQTYTDEIVELYNE
IRGFRHDYAGMLVSMQMAIDSGDLQEINRVYNEVLVKANQKLRSEKYTYFDLNNIEDSALRSLIAQSIVYARKNDVEFTL
EVKDIITRLSIDLLDLVRIMSILLNNAVEGAADSYLKQMEVAVIKMDFETVIVIQNSCKITMTPSEDLFALGFSTKGRNR
GLGLNNVKEILDKYDNIILETEMEDNTFRQIIRFKREFE

Nucleotide


Download         Length: 1320 bp        

>NTDB_id=516970 I6H78_RS05395 WP_000054555.1 1107767..1109086(+) (comD) [Streptococcus oralis strain FDAARGOS_1021]
ATGAGTTTATTAGGATTTGGAATAGTTATTCTTCATATTTTTATTTTAACAATAAGCTATGAATTAATTTGTAAAGTAAC
TAAAAAAGAAAGATATTTATTTATAGCTTGTATATTTGTATATCAGTCTGTAGCTGAATTTTTCTTTGACTTTATTTCAT
TAGCTGGGTTAGGGATTGAAAAGTTTATATTTCCTTTTATTCTATATACTTCTATAGTAGTTTTAAAGAAGTATGATAAG
CATAAAGGAATGTTTATCAGTTTACTATTGTCTTTATTATATCATAGTACACATACTTTTTTATCAGTAACCCTATCCTC
TATAACAGGTGATGCTTTTGTGATAGAACATGAAGTGATGTTTTATTTAGGAGTACTATTACTAACATATTTTATTATTA
AAAAAATTATTACTTATTTCCATTTAGAACTTACCTATTTTGATAAAGATTATCTGTATCCTTTTTTAAAAAAAGTAATA
GTTGCTTTCTTTGGTTTGCATATCTTATTGTTTATTTCAGATATAGTAAGTACAACTCATCATTTAAATAGCTTCGGAAG
TATTTTATCAACCATTGTTTTTATTTGCTTGTTATTGATTTTCTTTGCAATGAATTCTCACAAGGTTCAAATTGAAAAAG
AGATTGCTCTAAAACAAAAGAAATTTGAACAAAAACATTTACAGACTTATACTGATGAAATTGTGGAGTTGTATAATGAA
ATTCGAGGTTTTCGTCATGACTATGCAGGGATGCTTGTCAGCATGCAAATGGCGATTGACAGTGGAGATTTACAAGAAAT
TAACAGGGTTTACAATGAAGTCTTAGTAAAAGCAAATCAGAAATTGAGGTCAGAAAAATATACTTACTTTGATTTAAATA
ATATAGAAGATTCTGCTTTACGAAGTTTAATTGCTCAATCGATTGTCTATGCACGAAAAAATGATGTAGAGTTTACATTG
GAAGTAAAGGATATCATTACTAGACTGTCAATAGATTTACTTGATCTTGTTCGTATCATGAGCATTTTATTAAACAATGC
TGTTGAAGGTGCTGCAGATAGTTATTTGAAACAAATGGAAGTTGCAGTCATTAAAATGGATTTTGAAACAGTTATAGTTA
TCCAGAATTCATGCAAAATCACTATGACGCCTTCAGAGGACCTATTTGCCTTAGGTTTTTCTACCAAGGGAAGAAATAGA
GGTCTAGGACTTAATAATGTCAAAGAGATTTTAGATAAGTATGACAACATTATTTTAGAAACAGAGATGGAAGACAACAC
ATTTAGACAAATTATTAGATTTAAGAGGGAATTCGAATGA

Domains

Predicted by InterproScan.

GHKL domain (HATPase_c_5)

(333-432)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A1X1H723

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comD Streptococcus mitis NCTC 12261

75.737

100

0.761
  comD/comD2 Streptococcus pneumoniae TIGR4

74.603

100

0.749
  comD Streptococcus mitis SK321

74.376

100

0.747
  comD/comD1 Streptococcus pneumoniae R6

73.923

100

0.743
  comD/comD1 Streptococcus pneumoniae Rx1

73.923

100

0.743
  comD/comD1 Streptococcus pneumoniae D39

73.923

100

0.743
  comD/comD2 Streptococcus gordonii strain NCTC7865

50.798

85.649

0.435
  comD/comD1 Streptococcus gordonii str. Challis substr. CH1

50.267

85.194

0.428